The effects of caffeine exposure on postnatal growth in moderately preterm infants

The effects of caffeine exposure on postnatal growth in moderately preterm infants | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article The effects of caffeine exposure on postnatal growth in moderately preterm infants Antoinette Jones, Angelica Trybulska, Hongyue Wang, Jeffrey Meyers This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4565874/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective: To determine whether caffeine independently influenced linear growth during NICU hospitalization in moderately preterm infants. Study Design: We performed a single-center retrospective cohort study. Our primary outcome was the change in length z-score from birth to discharge or 37 weeks’ corrected gestational age (CGA). Secondary outcomes included change in weight and head circumference z-scores. Multiple regression analysis controlling for an a priori list of covariates was performed to evaluate the association between caffeine dose and the growth outcomes. Results: In 308 infants 29-33 weeks' gestational age, greater cumulative caffeine dose was significantly associated with a progressive decline in length (p=0.04), weight (p=0.03), and head circumference z-scores, (p<0.05). Conclusion(s): Caffeine exposure in moderately preterm infants has an independent dose-dependent inverse relationship with linear growth, weight gain, and head growth. Figures Figure 1 Figure 2 Figure 3 Full Text Additional Declarations There is NO conflict of interest to disclose. Tables are available in the Supplementary Files section Supplementary Files AntoinetteNJonestable1fortheeffectsofcaffeineexposureonpostnatalgrowth.pdf AntoinetteNJonestable2fortheeffectsofcaffeineexposureonpostnatalgrowth.pdf AntoinetteNJonestable3fortheeffectsofcaffeineexposureonpostnatalgrowth.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4565874","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":314440440,"identity":"81012985-ead6-4831-8f60-9f38a65e4e4d","order_by":0,"name":"Antoinette 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Supplementary Files section\u003c/p\u003e","formattedTitle":"The effects of caffeine exposure on postnatal growth in moderately preterm infants","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4565874/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4565874/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Objective: \r\n\r\nTo determine whether caffeine independently influenced linear growth during NICU hospitalization in moderately preterm infants. \r\n\r\nStudy Design: \r\n\r\nWe performed a single-center retrospective cohort study. Our primary outcome was the change in length z-score from birth to discharge or 37 weeks’ corrected gestational age (CGA). Secondary outcomes included change in weight and head circumference z-scores. Multiple regression analysis controlling for an a priori list of covariates was performed to evaluate the association between caffeine dose and the growth outcomes. \r\n\r\nResults: \r\n\r\nIn 308 infants 29-33 weeks' gestational age, greater cumulative caffeine dose was significantly associated with a progressive decline in length (p=0.04), weight (p=0.03), and head circumference z-scores, (p\u003c0.05). \r\n\r\nConclusion(s): \r\n\r\nCaffeine exposure in moderately preterm infants has an independent dose-dependent inverse relationship with linear growth, weight gain, and head growth.","manuscriptTitle":"The effects of caffeine exposure on postnatal growth in moderately preterm infants","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-07-12 18:45:23","doi":"10.21203/rs.3.rs-4565874/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"7c0bfc22-2b61-47d6-9ebc-a5ab09b13d33","owner":[],"postedDate":"July 12th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-08-07T14:45:21+00:00","versionOfRecord":[],"versionCreatedAt":"2024-07-12 18:45:23","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4565874","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4565874","identity":"rs-4565874","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}