FSH receptor polimorphysm in infertile women with endometriosis

Gustavo Peretti Rodini, Fernanda dos Santos Pereira, Úrsula da Silveira Matte, Elisângela Arbo, Carlos Augusto Bastos de Souza, João Sabino Cunha‐Filho
In: JBRA Assisted Reproduction · 2008 · doi:10.5935/1518-0557.2008.12.4.02 · W4377084387
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated FSH receptor gene polymorphism (N680S) in infertile women with endometriosis compared to fertile controls, finding no significant difference in genotype prevalence between the groups.

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Abstract

Objective: Endometriosis affects between 10 and 15% of women of reproductive age. These patients have a 20 greater chance of being infertile and 30-60% of these patients are actually infertile. In this study, the prevalence of the foliculle stimulating hormone (FSH) gene receptor polimorfism will be studied in infertile patients with endometriosis. This polimorfism, witch modify the signal receptor transduction, could probably be responsible for the poor ovarian response towards FSH stimulation. Material And Methods: Preliminary results of a casecontrol study. The study group is infertile women with endometriosis. The control group is fertile patients without endometriosis. We will study the genotypic prevalence of the substitution of a aspargine (N) for a serine (S) in the 680 codon of exon 10 in both alleles of the FSH receptor gene synthesizer. Results: It was analyzed 49 patients, 31 in the study group and 18 in the control group. Both groups had nonstatistical differences regarding demographic characteristics. Among infertile patients with endometriosis, we found 5 homozygotic (S/S), 14 heterozygotic (N/S) and 12 genotipically normal (N/N). In the control group, we found 1 homozygotic (S/S), 9 heterozygotic (N/S) and 8 patients with normal genotype (N/N). There was no

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endometriosis

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