PROFIL PENGGUNAAN OBAT PADA PASIEN ENDOMETRIOSIS (Studi di Instalasi Rawat Jalan SMF Obstetri Ginekologi RSUD Dr. Soetomo Surabaya)

Background. The occurrence of endometriosis is closely related to the menstrual cycle and estrogen. Estrogen is the hormone that has definitively been established to support the growth and development of endome triosis. Drug therapy in patients with endometriosis should be given the right e ither type of drug, dosage, and time of administration because it is associated with female reproductive hormones in order to obtain a maximal therapy. Therefore it is nece ssary to study the drug profile in patients with endometriosis. Objective. The aim of this study was to analyz e the drugs utilization profile in endometriosis case, including type of drugs , dosage, route of administration, time and duration of drugs used, and to iden tify actual Drug Related Problems (DRP s ) Methods. This study has been performed at Obstetric Gynecology Department Dr. Soetomo Teaching Hospital Surabaya. This sample was at the period April, 1 st 2009 until March, 31 th 2011 (N=40). Patient’s data collecti on were reviewed retrospectively by using descriptive analysis. Results and Conclusions . Synthetic progesterone was used in 18 patients (32,5%), including depo medroxyprogesterone acetate (DMPA) (25%), and noretisteron (7,5%). Oral contraceptive was used in 29 patients (72,5%), danazol was used in 3 patients (7,5%), leuprorelin acetate was used in 5 patients (12,5%). All of the medicine was indicated to the same goa l of suppressing the growth of endometriosis and reducing the pain. Analgesic was also used to redu ce endometriosis related pain. Clomiphene citrate was administered in 3 patients (7,5%) to trigger ovulation and pregnancy in patients with infertility due to endometriosis. DRP s were identified in 13 patients (32,5%) and the most frequently DRPs was adve rse effect of oral contraceptive.