The transcription factors and its implications in adaptive evolution

The random to explain the emergence of variations in sequence of the alleles is the current scientific paradigm of evolutionary biology. Here is argued that external stimuli responsible of manifestation of an instinct together with transcription factors (TFs) involved are the main cause of emergence of such variations. Advances in epigenomics show that this molecular function plays an important role in the regulation of gene expression of all cells, both prokaryotes and eukaryotes, and indicates which specific genes should be transcribed and which should be translated. Under this context, the present work pretends evaluate the current evidence on the increase in mutation rate caused by transcription-associated mutational pressure in primordial germ cells due to presence of TFs also present in somatic cells involved in an instinct. In conclusion is established that adaptive evolution can understood as biological superposition of 4 functional states. This work that is added to the evolutionary theoretical framework contributes with an alternative causal understanding of adaptive evolution.