Therapeutic effect of treatment with surgery and mifepristone in patients with endometriosis

AIM: To evaluate the therapeutic effect of treatment with surgery and mifepristone in patients with endometriosis. METHODS: The medical records of 126 endometriosis patients undergoing surgical operation were analyzed retrospectively. There were 28 cases in stage Ⅰ or Ⅱ, 73 cases in stage Ⅲ, and 25 cases in stage Ⅳ. Conservative surgery was performed in 96 cases and semi-conservative surgery in 30 cases. Postoperation, 92 cases continued taking 10 mg·d~ -1 of mifepristone for 6 months and 34 cases did not. All patients received 3 to 5 years follow up. RESULTS: The complete remission (CR) rate in mifepristone group was 77.2 %, partial remission (PR) rate was 22.8 %, and recurrence rate was 16.3 %. The CR of controls was 52.9 %, PR was 47.1 %, and recurrence rate was 32.4 %. There was significant difference between two groups (P 0.05 ). The side effect of mifepristone occurred in 17.4 % of all patients, but it eliminated the remained lesions in 89.1 % of all patients. The levels of estradiol, progestin and CA125 in serum from pretreatment or recurrent patients were significantly higher than the patients with posttreatment of mifepristone (P 0.05 ). CONCLUSION: Surgery is the principal method for treating endometriosis. Taking mifepristone can improve the prognosis, and decrease the recurrence rate, and maintain the serum markers at normal levels.