Increased endometrial expression of CC-chemokine receptor-1 in women with adenomyosis.
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Endometrial messenger RNA and protein expression of CC-chemokine receptor-1 were significantly increased in women with adenomyosis compared to controls.
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Abstract
Abnormal endometrial expression of CC-chemokine receptor-1 (CCR1) may play a role in the pathogenesis of endometriosis. Adenomyosis, also called endometriosis interna, occurs when the endometrium invades the myometrium. The objective of this study was to determine CCR1 expression in endometrium in women with adenomyosis as compared to women without adenomyosis. We evaluated endometrial mRNA and protein expression in women with and without adenomyosis using quantitative polymerase chain reaction (PCR), immunohistochemical staining and western blot analysis, respectively. We detected CCR1-immunoreactive expression in endometrium in all women with and without adenomyosis. CCR1-immunoreactive staining in endometrial cells was significantly higher in women with adenomyosis (4.89±1.06) compared to those without adenomyosis (2.21±1.16, P<0.001). Women with adenomyosis had higher levels of CCR1 mRNA in endometrium compared to women without adenomyosis (P<0.05). CCR1 protein levels in endometrium were significantly higher in women with adenomyosis (1.66±0.79) compared to women without adenomyosis (0.56±0.13, P<0.001), and positively correlated with the severity of dysmenorrhea (r=0.87, P<0.001). These results suggest that increased CC-chemokine receptor expression may play a role in the pathogenesis of adenomyosis.
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Increased endometrial expression of CC-chemokine receptor-1 in women with adenomyosis
Hong Xu*, Yanfeng Yang*, Caiyun Zhou, Xiufeng Huang, Jun Lin and Xinmei Zhang
Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
*Yanfeng Yang´s contribution is the same as Hong Xu
Offprint requests to: Xinmei Zhang, The Department of Gynecology, Women’s Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, Zhejiang, P.R. China, 310006. e-mail: [email protected]
Summary. Abnormal endometrial expression of CC-chemokine receptor-1 (CCR1) may play a role in the pathogenesis of endometriosis. Adenomyosis, also called endometriosis interna, occurs when the endometrium invades the myometrium. The objective of this study was to determine CCR1 expression in endometrium in women with adenomyosis as compared to women without adenomyosis. We evaluated endometrial mRNA and protein expression in women with and without adenomyosis using quantitative polymerase chain reaction (PCR), immunohistochemical staining and western blot analysis, respectively. We detected CCR1-immunoreactive expression in endometrium in all women with and without adenomyosis. CCR1-immunoreactive staining in endometrial cells was significantly higher in women with adenomyosis (4.89±1.06) compared to those without adenomyosis (2.21±1.16, P<0.001). Women with adenomyosis had higher levels of CCR1 mRNA in endometrium compared to women without adenomyosis (P<0.05). CCR1 protein levels in endometrium were significantly higher in women with adenomyosis (1.66±0.79) compared to women without adenomyosis (0.56±0.13, P<0.001), and positively correlated with the severity of dysmenorrhea (r=0.87, P<0.001). These results suggest that increased CC-chemokine receptor expression may play a role in the pathogenesis of adenomyosis. Histol Histopathol 29, 1153-1160 (2014)
Key words: CC-chemokine receptor-1, Dysmenorrhea, Endometrium, Adenomyosis
DOI: 10.14670/HH-29.1153
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Cited by (3)
- Efficacy of laparoscopic adenomyomectomy using double-flap method for diffuse uterine adenomyosis 2015
- A new trick for an old dog: The application of mifepristone in the treatment of adenomyosis 2019
- Investigation of the 12-month efficacy and safety of low-dose mifepristone in the treatment of painful adenomyosis 2022
Cited by (3)
- Investigation of the 12-month efficacy and safety of low-dose mifepristone in the treatment of painful adenomyosis 2022
- A new trick for an old dog: The application of mifepristone in the treatment of adenomyosis 2019
- Efficacy of laparoscopic adenomyomectomy using double-flap method for diffuse uterine adenomyosis 2015
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