Increased endometrial expression of CC-chemokine receptor-1 in women with adenomyosis.

Xu H, Hong Xu, Yang Y, Yanfeng Yang, Caiyun Zhou, Zhou C, Xiufeng Huang, Lin J, Jun Lin, Xinmei Zhang, Zhang X
Histology and histopathology · 2014 · vol. 29(9) , pp. 1153–60 · doi:10.14670/hh-29.1153 · PMID:24599574 · W2302858979
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Endometrial messenger RNA and protein expression of CC-chemokine receptor-1 were significantly increased in women with adenomyosis compared to controls.

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This study investigated the expression levels of CC-chemokine receptor-1 (CCR1) in the endometrium of women diagnosed with adenomyosis compared to a control group without the condition. Using quantitative PCR, immunohistochemistry, and western blot analysis, researchers found that both mRNA and protein levels of CCR1 were significantly elevated in the adenomyosis group. The increased protein expression positively correlated with the severity of dysmenorrhea, suggesting a potential role for CCR1 in the disease's pathogenesis. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

Abnormal endometrial expression of CC-chemokine receptor-1 (CCR1) may play a role in the pathogenesis of endometriosis. Adenomyosis, also called endometriosis interna, occurs when the endometrium invades the myometrium. The objective of this study was to determine CCR1 expression in endometrium in women with adenomyosis as compared to women without adenomyosis. We evaluated endometrial mRNA and protein expression in women with and without adenomyosis using quantitative polymerase chain reaction (PCR), immunohistochemical staining and western blot analysis, respectively. We detected CCR1-immunoreactive expression in endometrium in all women with and without adenomyosis. CCR1-immunoreactive staining in endometrial cells was significantly higher in women with adenomyosis (4.89±1.06) compared to those without adenomyosis (2.21±1.16, P<0.001). Women with adenomyosis had higher levels of CCR1 mRNA in endometrium compared to women without adenomyosis (P<0.05). CCR1 protein levels in endometrium were significantly higher in women with adenomyosis (1.66±0.79) compared to women without adenomyosis (0.56±0.13, P<0.001), and positively correlated with the severity of dysmenorrhea (r=0.87, P<0.001). These results suggest that increased CC-chemokine receptor expression may play a role in the pathogenesis of adenomyosis.
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Increased endometrial expression of CC-chemokine receptor-1 in women with adenomyosis Hong Xu*, Yanfeng Yang*, Caiyun Zhou, Xiufeng Huang, Jun Lin and Xinmei Zhang Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China *Yanfeng Yang´s contribution is the same as Hong Xu Offprint requests to: Xinmei Zhang, The Department of Gynecology, Women’s Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, Zhejiang, P.R. China, 310006. e-mail: [email protected] Summary. Abnormal endometrial expression of CC-chemokine receptor-1 (CCR1) may play a role in the pathogenesis of endometriosis. Adenomyosis, also called endometriosis interna, occurs when the endometrium invades the myometrium. The objective of this study was to determine CCR1 expression in endometrium in women with adenomyosis as compared to women without adenomyosis. We evaluated endometrial mRNA and protein expression in women with and without adenomyosis using quantitative polymerase chain reaction (PCR), immunohistochemical staining and western blot analysis, respectively. We detected CCR1-immunoreactive expression in endometrium in all women with and without adenomyosis. CCR1-immunoreactive staining in endometrial cells was significantly higher in women with adenomyosis (4.89±1.06) compared to those without adenomyosis (2.21±1.16, P<0.001). Women with adenomyosis had higher levels of CCR1 mRNA in endometrium compared to women without adenomyosis (P<0.05). CCR1 protein levels in endometrium were significantly higher in women with adenomyosis (1.66±0.79) compared to women without adenomyosis (0.56±0.13, P<0.001), and positively correlated with the severity of dysmenorrhea (r=0.87, P<0.001). These results suggest that increased CC-chemokine receptor expression may play a role in the pathogenesis of adenomyosis. Histol Histopathol 29, 1153-1160 (2014) Key words: CC-chemokine receptor-1, Dysmenorrhea, Endometrium, Adenomyosis DOI: 10.14670/HH-29.1153

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Condition tags

endometriosisadenomyosisdysmenorrhea

MeSH descriptors

Adenomyosis Adenomyosis Endometrium Endometrium Receptors, CCR1 Adenomyosis Adult Blotting, Western Endometrium Female Humans Immunohistochemistry Middle Aged Real-Time Polymerase Chain Reaction Receptors, CCR1 Receptors, CCR1

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