Differential Effects of Intrinsic- Versus Extrinsic-First Corrective Exercise Programs on Morphometric Outcomes and Navicular Drop in Pediatric Pes Planus

Differential Effects of Intrinsic- Versus Extrinsic-First Corrective Exercise Programs on Morphometric Outcomes and Navicular Drop in Pediatric Pes Planus | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Differential Effects of Intrinsic- Versus Extrinsic-First Corrective Exercise Programs on Morphometric Outcomes and Navicular Drop in Pediatric Pes Planus Jafar Ketabchi, Foad Seidi, Shila Haghighat, Sue Falsone, Yousef Moghadas-Tabrizi, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3974670/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 28 Dec, 2024 Read the published version in Scientific Reports → Version 1 posted 12 You are reading this latest preprint version Abstract Although the connection between muscular strength and flatfoot condition is well-established, the impact of corrective exercises on these muscles remains inadequately explored. This study aimed to assess the impact of intrinsic- versus extrinsic-first corrective exercise programs on muscle morphometry and navicular drop in boys with flexible flatfoot. Twenty-five boys aged 10–12 with flexible flatfoot participated, undergoing a 12-week corrective exercise program, with a shift in focus at six weeks. Ultrasound imaging measured muscle thickness and cross-sectional area (CSA), and the navicular drop test assessed flatfoot severity. The results demonstrated a significant interaction between exercise type and sequencing on muscle morphometry. Initiating with intrinsic exercises led to sustained improvement, even after transitioning to extrinsic exercises, while extrinsic-first exercises caused deterioration in intrinsic muscle morphology, which was recovered after transitioning to intrinsic exercises. Statistical analysis revealed significant improvements in muscle thickness and CSA over time, particularly when initiating intrinsic exercises first. The intrinsic-first group also exhibited a more pronounced reduction in navicular drop. In conclusion, initiating corrective exercises with intrinsic muscles proved more effective in improving foot muscle morphometry and reducing navicular drop in boys with flatfoot. Therefore, commencing correction with intrinsic muscle exercises is recommended before progressing to extrinsic muscle exercises. Iranian Registry of Clinical Trials (IRCT20210818052223N1) on 2021-09-08 Health sciences/Health care Health sciences/Health occupations Health sciences/Medical research flatfoot foot deformity medial longitudinal arch Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 1. Introduction Flatfoot is a common pediatric foot abnormality [ 1 ] characterized by a reduced medial longitudinal arch (MLA), and a consequential navicular drop [ 2 ]. While various ligaments and fascia support the MLA, muscles also play an indispensable role in the maintenance of the MLA [ 3 ], giving rise to a dichotomy: intrinsic versus extrinsic muscular groups [ 4 ]. The intrinsic muscles such as the abductor hallucis (ABH) and flexor digitorum brevis (FDB), are anatomically situated with both origins and insertions in close proximity to the foot bones [ 5 ]. These muscles are considered to be primary local stabilizers of the MLA by virtue of their small moment arms and intimate bone-to-bone tethering [ 6 ]. Conversely, the extrinsic muscles—tibialis anterior (TA), tibialis posterior (TP), and flexor digitorum longus (FDL)—although extraneous to the foot in origin, provide vital reinforcement to the MLA [ 4 ]. Their leverage positions these muscles as dynamic mobilizers, crucial for the generation of propulsive forces during locomotion [ 6 ]. The nuanced collaborative mechanics of these muscle groups are integral to the sustainment of the MLA, thus accentuating the clinical pertinence of assessing their morphometry, namely thickness and CSA, as potential reflective markers for foot disorders such as flat feet [ 7 , 8 ]. Nevertheless, there is a scarcity in the literature regarding detailed evaluations of the attributes of specific intrinsic and extrinsic foot muscles in cases of flatfoot [ 9 , 10 ]. Disparities in the CSA of intrinsic and extrinsic foot muscles among populations with healthy versus pronated feet in adulthood [ 11 ] imply potential morphometric remodifications, wherein extrinsic muscular adaptations are posited to compensate for intrinsic deficits [ 7 ]. This adaptation suggested by the research of Angin et al. [ 7 ], observing greater thickness and CSA in extrinsic foot muscles compared to intrinsic ones in individuals with pronated foot disorders, could potentially highlight a compensatory model of extrinsic-muscular hypertrophy in response to pronation stresses. Meanwhile, discrepancies in intrinsic muscle development between flat-footed individuals and their healthy counterparts have surfaced [ 12 ], fueling discussions on the role of exercises tailored to these muscles in preventing and potentially rectifying navicular drop [ 13 , 14 ]. Jung et al. [ 13 ] have reported that short foot exercises, combined with foot orthoses, can enhance the CSA of key intrinsic foot muscles like the ABH. Supporting this view, Mulligan and Cook [ 14 ] have suggested that short foot exercises might be effective in preventing navicular drop by strengthening the intrinsic foot muscles. The concept of a ‘foot core system’ [ 3 , 6 ], extrapolated from Richardson and Hodges’ lumbar stability model [ 15 ], offers an innovative perspective through McKeon’s lens on foot musculature, conceptualizing intrinsic muscles as pivotal ‘local core stabilizers’ countered by ‘global core stabilizers’ represented by the extrinsic muscle cadre [ 3 , 6 ]. This neurophysiological paradigm postulates that priming intrinsic muscles prior to their extrinsic counterparts may avert potential weakening of local musculature—a principle that, if substantiated, could revolutionize the approach to foot muscle rehabilitation. Noninvasive modalities such as corrective exercises, categorized by their focus on either intrinsic or extrinsic muscle groups, have gained prominence for their efficacy on the MLA [ 14 , 16 ]. Contemporary literature on the intrinsic musculature of the foot lacks comparative exploration of intrinsic versus extrinsic muscle-focused training effects subject to different prioritizations on muscle morphometry [ 13 , 14 , 16 , 17 ]. Consequently, there needed to conduct an empirical study to figure out the muscular adaptations of the foot consequent to differential training methodologies. This study was hence designed to unravel the morphometric differences in selected intrinsic and extrinsic foot muscles contingent on the prioritization and timing of corrective exercises, and secondly, to ascertain the consequential variance in navicular drop amongst pediatric participants with flatfoot. It carries forward the hypothesis that initiation of corrective exercises with an extrinsic emphasis may inadvertently catalyze intrinsic muscle atrophy and exacerbate flatfoot deformities. The findings of this research endeavor aimed to illuminate the optimal sequencing of corrective exercises, potentially steering a new course for future therapeutic strategies in the management of flatfoot. 2. Methods 2.1. Participants Ethical clearance was granted by the Faculty of Physical Education and Sport Sciences at the University of Tehran (IR.UT.SPORT.REC.1399.008) and the Iranian Registry of Clinical Trials (IRCT20210818052223N1 on 08/09/2021). Prospective interventional trial with a within-subject crossover design was used. For the study, twenty-five boys suffering from flexible flat feet were enlisted from elementary schools, ranging in age from 10 to 12 years. Informed consent was secured from their parents or legal guardians. All methods were carried out in accordance with the Declaration of Helsinki. During the exercise intervention, three participants opted out of the study due to a lack of interest in continuing the collaboration with the researchers, which left twenty-two subjects. These remaining participants were randomly assigned to two groups: the intrinsic-first corrective exercise group (n = 10, average age 10.8 ± 0.78 years, height 138.8 ± 7.22 cm, weight 40.7 ± 9.49 kg) and the extrinsic-first corrective exercise group (n = 12, average age 11 ± 0.85 years, height 143.1 ± 6.14 cm, weight 42.25 ± 9.05 kg). Computer-generated randomization was used in a 1:1 ratio, followed by a masked allocation by opening the sequentially numbered, checkmate, and secured envelopes. A card inside each envelope indicated the group where the participant was randomly allocated, i.e. intervention or control groups. Candidates for the study met inclusion criteria of having an orthopedist-diagnosed asymptomatic flexible flatfoot and a navicular drop test score of ≥ 10 millimeters (mm). Exclusions were made for participants with any anatomical leg length discrepancies, a history of foot or leg surgery or injury, a diagnosis of structural flatfoot, a positive tarsal coalition test, current use of insole orthotics, or congenital lower extremity deformities such as genu valgum or femoral anteversion. 2.2. Protocol Images of the foot muscles, including the FDL, FDB, ABH, TA, and TP, were captured using an ultrasound system (US) (E-cube 9, Alpinion Medical Systems, Seoul, Korea) equipped with a 3–10 MHz linear wideband array transducer. The evaluation was focused on the participants’ dominant limb during stance—the leg that each individual instinctively used when asked to perform a single-leg balance task. These assessments were carried out by a trained examiner blinded to group allocation, adhering to a methodology laid out by Crofts et al [ 8 ]. For accurate muscle thickness measurement, the probe was meticulously aligned parallel to the muscle fibers. To determine the CSA, the probe was pivoted by 90 degrees to lie perpendicular to the fibers at the muscle’s thickest portion [ 8 ]. In the pursuit of precision, the mean value derived from three separate measurements was taken for each muscle to ensure robust statistical analysis. Figure 1 illustrates the probe positioning and sample images for all recorded measurements. 2.3. Measurement of navicular drop According to Brody’s methodology for the navicular drop test [ 18 ], participants were seated with the hips, knees, and ankles at 90-degree angles and the tibia perpendicular to the floor. The examiner, blinded to group assignments, used the thumb and index finger to palpate the anteromedial and anterolateral aspects of the talus. The participant’s foot was rotated internally and externally to identify the subtalar joint’s neutral position, where the talus was palpably centered between the examiner’s fingers. The navicular bone’s height from the floor was measured in this position using a digital caliper. Following this, the participant stood, ensuring an equal distribution of body weight and a perpendicular tibia to the floor; the navicular height was measured again. The difference between seated and standing measurements provided the navicular drop value. 2.4. Intervention Participants underwent a 12-week corrective exercise program, comprising three 45-minute sessions per week. The intrinsic-first group initially dedicated the first six weeks to performing exercises targeting the foot’s intrinsic muscles. Subsequently, for the latter half of the program, they switched to focusing on extrinsic muscle exercises. Conversely, the extrinsic group commenced with extrinsic muscle exercises for the initial six weeks and switched to intrinsic ones for the remaining six weeks of the program. 2.4.1. Intrinsic foot exercises The intrinsic foot exercise program commenced with non-weight-bearing (unloaded) exercises, such as sitting, and advanced to weight-bearing (loaded) scenarios such as standing and single-leg stances once muscle activation proficiency was achieved [ 3 ]. Activities included short foot exercises, toe spreading, first toe extensions, and extensions of the second to fifth toes (Fig. 2 ). Gooding et al. [ 17 ] noted that these exercises led to heightened intrinsic muscle activation. Similarly, Jung et al. [ 19 ] found that short foot exercises elicited greater electromyographic activity in the ABH compared to conventional toe curls. 2.4.2. Extrinsic foot exercise The extrinsic foot exercise program was structured to activate and strengthen the extrinsic foot muscles, with a particular emphasis on the posterior tibialis muscle due to its critical function in supporting the MLA [ 20 ]. It comprised exercises such as foot adduction, heel raises, and foot supination, which were performed both with an elastic band and against gravity, as illustrated in Fig. 3 . Research by Kulig and colleagues [ 21 ] has demonstrated that the first three exercises are particularly effective in selectively engaging the extrinsic muscles of the foot, most notably the tibialis posterior. Initially, exercises were performed with minimal resistance, gradually incorporating heavier loads facilitated by an elastic band. 2.5. Statistical analysis Data normality and variance homogeneity were ascertained using the Kolmogorov–Smirnov test before comprehensive statistical evaluation. A two-way repeated measures ANOVA examined the group effects (intrinsic and extrinsic), time effects (initial, the 6th week, the 12th week), and interaction effects (Group × Time) on the dependent variables of muscle thickness, CSA, and navicular drop. Bonferroni post hoc analysis was applied for pairwise comparisons at consecutive time points. P-values less than 0.05 were deemed statistically significant, with analyses performed using SPSS software (version 26.0; SPSS, Inc, an IBM Company, Chicago, IL). 3. Results Mixed ANOVA revealed significant interactions between the groups (Intrinsic, Extrinsic) and time (Initial, the 6th week, the 12th week) on the thickness of FDL (F 1,20 =9.43, P = 0.002), FDB (F 1,20 =4.13, P = 0.043), ABH (F 1,20 = 4.30, P = 0.035), TA (F 1,20 = 5.16, P = 0.013), and TP (F 1,20 = 4.36, P = 0.021). A significant main effect of time was observed for the following muscles: FDB (F 1,20 =9.33, P = 0.003), ABH (F 1,20 =6.52, P = 0.010), TA (F 1,20 =6.31, P = 0.006), and TP (F 1,20 =3.77, P = 0.034). No significant effects were detected for group differences in all muscle variables related to thickness (p > 0.05). Regarding the CSA, significant interactions were found for FDL (F 1,20 =4.47, P = 0.018), and ABH (F 1,20 =5.66, P = 0.014). A significant main effect of time was observed for the following muscles: FDL (F 1,20 =3.26, P = 0.04), FDB (F 1,20 =11.01, P < 0.001), and TP (F 1,20 =3.69, P = 0.034), indicating a temporal evolution in these measures. Conversely, no significant group effect Additionally, for navicular drop, a significant effect of time was noted (F 1,20 =55.65, P 0.05). Tables 1 and 2 present the mean values, results of post hoc analyses, and the percentage of change in outcome measures from baseline to follow-ups at 6th and 12th weeks for both groups. Table 1 Mean (SD) changes in navicular drop and the thickness of selected muscles from baseline to follow-ups at 6th and 12th weeks Variable Group Initial 6th week 12th week p and % Change Initial to 6 weeks p and % Change Initial to 12 weeks p and % Change 6 weeks to 12 weeks Interaction effect Test time effect Group effect Flexor digitorum longus (cm) Intrinsic 1.26 ± 0.43 1.08 ± 0.51 1.23 ± 0.61 P = 0.09 -14% P = 1.00 -2% P = 0.95 -14% F = 9.34 P = 0.002* F = 3.07 P = 0.077 F = 2.26 P = 0.148 Extrinsic 1.42 ± 0.40 1.79 ± 0.52 1.20 ± 0.50 P < 0.001 26% P = 0.44 -15% P = 0.001 -33% Flexor digitorum brevis (cm) Intrinsic 0.72 ± 0.23 0.71 ± 0.36 0.78 ± 0.33 P = 1.00 -1% P = 1.00 8% P = 1.00 10% F = 4.13 P = 0.043* F = 9.33 P = 0.003* F = 0.07 P = 0.791 Extrinsic 0.67 ± 0.19 0.55 ± 0.17 0.90 ± 0.38 P = 0.012 -18% P = 0.026 34% P < 0.001 63% Abductor hallucis (cm) Intrinsic 0.81 ± 0.24 0.91 ± 0.37 0.94 ± 0.40 P = 0.48 12% P = 0.85 16% P = 1.00 3% F = 4.30 P = 0.035* F = 6.52 P = 0.010* F = 1.50 P = 0.234 Extrinsic 0.73 ± 0.23 0.58 ± 0.14 0.95 ± 0.36 P = 0.07 -21% P = 0.14 30% P < 0.001 64% Tibialis anterior (cm) Intrinsic 1.87 ± 0.41 1.74 ± 0.44 2.06 ± 0.58 P = 0.78 -7% P = 0.47 10% P = 0.012 18% F = 5.16 P = 0.013* F = 6.31 P = 0.006* F = 3.71 P = 0.068 Extrinsic 1.94 ± 0.29 2.30 ± 0.37 2.29 ± 0.34 P = 0.006 19% P = 0.022 18% P = 1.00 -0.5% Tibialis posterior (cm) Intrinsic 2.07 ± 0.33 1.92 ± 0.39 2.29 ± 0.54 P = 0.72 -7% P = 0.25 11% P = 0.005 19% F = 4.36 P = 0.021* F = 3.77 P = 0.034* F = 0.26 P = 0.613 Extrinsic 2.03 ± 0.31 2.27 ± 0.44 2.22 ± 0.45 P = 0.16 12% P = 0.28 9% P = 1.00 -2% Navicular Drop (cm) Intrinsic 1.54 ± 0.45 1.12 ± 0.32 0.81 ± 0.26 P < 0.001 -27% P < 0.001 -47% P = 0.003 -27% F = 0.23 P = 0.70 F = 55.65 P˂0.001* F = 0.77 P = 0.391 Extrinsic 1.64 ± 0.58 1.25 ± 0.40 1.00 ± 0.34 P < 0.001 -24% P < 0.001 -39% P = 0.01 -20% *Indicates difference (P < .05). Table 2 Mean (SD) changes in the CSA of selected muscles from baseline to follow-ups at 6th and 12th weeks Variable Group Initial 6th week 12th week p and % Change Initial to 6 weeks p and % Change Initial to 12 weeks p and % Change 6 weeks to 12 weeks Interaction effect Test time effect Group effect Flexor digitorum longus (cm) Intrinsic 2.52 ± 2.28 2.43 ± 2.17 2.68 ± 2.03 P = 1.00 -4% P = 1.00 6% P = 0.15 10% F = 1.59 P = 0.217 F = 3.26 P = 0.049* F = 1.28 P = 0.270 Extrinsic 1.60 ± 0.51 1.90 ± 0.59 1.99 ± 0.41 P = 0.17 19% P = 0.12 24% P = 1.00 5% Flexor digitorum brevis (cm) Intrinsic 1.46 ± 0.92 1.58 ± 0.96 1.64 ± 0.89 P = 0.53 8% P = 0.054 12% P = 1.00 4% F = 4.47 P = 0.018* F = 11.01 P˂0.001* F = 0.08 P = 0.786 Extrinsic 1.42 ± 0.57 1.31 ± 0.66 1.68 ± 0.55 P = 0.55 -8% P = 0.001 18% P < 0.001 28% Abductor hallucis (cm) Intrinsic 1.34 ± 0.59 1.59 ± 0.80 1.60 ± 0.80 P = 0.15 18% P = 0.21 19% P = 1.00 1% F = 5.66 P = 0.014* F = 1.61 P = 0.219 F = 0.04 P = 0.854 Extrinsic 1.55 ± 0.55 1.29 ± 0.52 1.53 ± 0.55 P = 0.09 -17% P = 1.00 -1% P = 0.006 18% Tibialis anterior (cm) Intrinsic 5.80 ± 1.86 5.26 ± 1.77 5.65 ± 2.00 P = 0.164 -9% P = 1.00 -3% P = 0.18 7% F = 2.03 P = 0.145 F = 1.29 P = 0.286 F = 0.001 P = 0.978 Extrinsic 5.68 ± 1.51 5.68 ± 1.20 5.40 ± 1.06 P = 1.00 0% P = 1.00 -5% P = 0.41 -5% Tibialis posterior (cm) Intrinsic 3.71 ± 0.69 3.83 ± 0.50 4.63 ± 0.75 P = 1.00 3% P = 0.17 25% P = 0.24 21% F = 2.35 P = 0.108 F = 3.69 P = 0.034* F = 0.97 P = 0.337 Extrinsic 4.08 ± 1.56 4.94 ± 1.88 4.59 ± 1.68 P = 0.008 21% P = 0.72 13% P = 1.00 -7% *Indicates difference (P < .05). 4. Discussion In the investigation of intrinsic- versus extrinsic-first corrective exercise programs for pediatric flexible flatfoot, the current study adeptly explored the hypothesis that not only the kinds of exercises but also their sequence of implementation may significantly impact the morphometry of foot muscles and the degree of navicular drop. The study results indicated that intrinsic corrective exercises, like short foot exercises, during the initial six weeks for the intrinsic-first group led to an improvement in the muscle thickness and CSA of intrinsic muscles such as FDB (decrease of 1%, increase of 8%) and ABH (increase of 12%, 18%). These findings suggest that intrinsic-first strategy to the corrective exercise program does not adversely affect the morphometry of either intrinsic or extrinsic foot muscles. Even, subsequent implementation of extrinsic corrective exercises in the latter six-week period (from weeks 6 to 12) resulted in continued improvements in intrinsic foot muscles, evidenced by FDB (10%, 4%) and ABH (3%, 1%) gains in addition to enhanced muscle thickness and CSA of extrinsic muscles, including TA (18%, 7%) and TP (19%, 21%). In other words, training these muscles seems to provide a stable base for the extrinsic muscles to function more effectively. Hence, the initial focus on intrinsic muscle exercises not only exhibited a protective effect on the morphometry of these smaller muscles, but also extended benefits to the subsequent development of extrinsic muscles. This finding is a compelling endorsement of the foot core system theory, positing that a proximodistal approach to foot muscle rehabilitation may yield the most favorable outcomes in managing pediatric flatfoot [ 3 , 6 ]. Our investigation also revealed that extrinsic corrective exercises during the initial six-week phase contributed to an adverse alteration in the morphometry of intrinsic muscles, while exerting beneficial effects on extrinsic musculature. Specifically, the muscle thickness and CSA of the intrinsic muscles, such as FDB (decreased by 18%, 8%) and ABH (decreased by 21%, 17%), exhibited declines, whereas the respective indices for extrinsic muscles, such as FDL (increased by 26%, 19%), TA (increased by 19%, unchanged), and TP (increased by 12%, 21%) incremented. This finding pivotally emphasized the potential negative impact of extrinsic-first strategy to the corrective exercise program. This sequence showed reduced morphometric benefits for the intrinsic muscles, a discovery that resonates with the foundational principles of neuromuscular rehabilitation, suggesting a potential interference effect where early extrinsic-muscle-training emphasis may overshadow intrinsic muscle development [ 15 ]. Intrinsic corrective exercises in the following six-week period led to substantial enhancements in the thickness and CSA of the intrinsic muscles, evidenced by increments in FDB (63%, 28%) and ABH (64%, 18%). Contrary to lumbar stability model [ 15 ], this intriguing result suggests that initiating training with the extrinsic foot muscles did not yield significantly different outcomes from commencing with intrinsic muscle emphasis. It should be noted that the six-week training period may not have been sufficient to fully differentiate the effects of training the intrinsic versus extrinsic foot muscles. Extending the duration of the training periods and incorporating longitudinal assessments could provide more comprehensive insights into the temporal dynamics of muscle adaptation in the lower extremities. Moreover, the divergence observed in the training sequence effects on foot musculature may stem from the distinct roles of the intrinsic foot muscles and the inner core unit. The intricate functions of the intrinsic foot muscles, specifically in supporting the foot arches and facilitating proper foot mechanics, may deviate from the sequential training efficacy proposed for the core musculature. The limited empirical researches in this field presents challenges to directly correlating current findings with established literature. Nevertheless, it appears that both intrinsic and extrinsic foot muscles follow a consistent response pattern to both extrinsic-muscle-targeted exercises and certain pathophysiological conditions. Notably, Angin et al. [ 7 ] documented a decrease in the thickness and CSA of the ABH, flexor hallucis brevis, and the peronei longus and brevis, while reporting an increase in these metrics for the FDL and peronei muscles in flatfooted conditions. These findings suggest potential compensatory adaptation by the extrinsic muscles to uphold the MLA when intrinsic muscle functionality is compromised due to anomalous foot structure. The same compensatory response of extrinsic foot muscles—the increase in thickness and CSA—to both early extrinsic-muscle-training interventions over a controlled period and natural pathological conditions (i.e., flat feet) not only entails the adoption of more conscious intrinsic-first strategy to the corrective exercise program, but also seems to be indicative of a complex interplay between the intrinsic and extrinsic muscles, a phenomenon that can either support or undermine the structure and function of the foot, depending on the scenario. The results suggest a potential interference effect, where early emphasis on extrinsic muscle training may negatively impact the improvement of intrinsic muscles. Strengthening extrinsic foot muscles, which originate on the leg and insert on the foot, can potentially lead to intrinsic foot muscle atrophy due to a phenomenon known as "muscle imbalance" or "disuse atrophy" [ 22 ]. When extrinsic muscles are strengthened, they may take over the functions that intrinsic muscles typically perform, such as supporting the arch and aiding in foot movements. This can lead to underuse of the intrinsic muscles, which may then weaken and atrophy over time [ 23 ]. When extrinsic muscles become stronger or more dominant, the intrinsic muscles may not receive the necessary stimulus to maintain their strength and function, leading to atrophy [ 24 ]. It is also worth delving deeper into the anatomy underlying these observations. Intrinsic muscles, acting as local stabilizers, have shorter lever arms and are tailored for fine-tuned support of the MLA [ 6 ]. Indeed, intrinsic foot muscles have been shown to provide afferent information and a stable base of support for balance, changing the shape of the foot according to the loading [ 24 ]. However, they are more prone to atrophy or functional impairment when not adequately prioritized in rehabilitative processes [ 25 ]. Conversely, training intrinsic foot muscles can play a crucial role in enhancing not only the intrinsic muscles but also the extrinsic muscles indirectly [ 26 ]. For instance, increased muscle activity in the intrinsic foot muscles has been associated with increased foot stiffness, which is beneficial for propulsion during gait [ 27 ] performed partly by TP [ 28 ].The enhancement of extrinsic muscle morphometry following intrinsic muscle training could suggest a neuromuscular adaptation that aligns with a foundational before functional training paradigm [ 15 ]—a concept embraced widely in core stabilization literature. The differential impact on the navicular drop—a chief metric in assessing flatfoot severity—furthers the discourse on the importance of exercise sequencing. Participants subjected to intrinsic muscle training showed a more substantial reduction in navicular drop (47%), though not statistically significant, compared to the extrinsic group (39%) over a 12-week training period, elevating the intrinsic-first strategy as a potentially superior strategy not only for muscle morphometry but also for functional foot correction. Numerous studies have reported improvements in the stability of the MLA following the strengthening of the intrinsic foot muscles [ 14 , 29 , 30 ]. Lucas et al. (2017) has asserted that exercises aimed at strengthening the intrinsic muscles of the foot are effective in enhancing the windlass mechanism and reducing the rate of navicular drop [ 31 ]. Although the primary factors affecting this mechanism are traditionally associated with the plantar fascia, the researchers believe that due to the extensive adhesions of the intrinsic foot muscles to the plantar fascia, strengthening these muscles could potentially increase tension in the fascia which in turn, may contribute to the improvement of the MLA, particularly during dynamic activities [ 31 , 32 ]. During the gait cycle, substantial forces impact the foot and especially the MLA, thus strengthening the mechanism resistance to these forces can help the arch function as a stronger lever to maintain stability against external forces [ 20 ]. The interplay between foot structures and muscular function seem to further account for the way musculature influences foot configuration. Empirical studies suggest that the weakening of both extrinsic and intrinsic foot muscles, such as TP and ABH, precipitates a decrease in MLA height [ 9 , 33 ]. Investigating static foot alignment through the navicular drop test and arch height index, Mulligan et al. [ 14 ] established that short-foot exercise yielded improvements within four weeks. Complementarily, Sulowska et al. [ 16 ] substantiated the positive effects of intrinsic muscle-strengthening exercises, reporting enhancement in the static foot alignment of long-distance runners after a six-week period of short-foot training, as assessed by the Foot Posture Index. Based on findings, extrinsic-first muscle training also seems to significantly improve navicular drop. Considering the insertion points of the extrinsic muscles, particularly the TA and the TP muscles - the former attaching from above and the latter from the inferomedial aspect - it can be posited that these muscles may also exert considerable effects on controlling navicular drop. As such, no significant difference was observed between the two groups in terms of navicular drop. Therefore, it is deduced that both intrinsic and extrinsic muscles can contribute to the improvement of navicular drop and the control of foot pronation. Despite the compelling findings, the study acknowledges several limitations—including the sample size and the absence of physical activity control—without which the external validity of these results may be circumscribed. Additionally, reliance on static foot measures like the navicular drop test as the sole outcome for foot structure change serves as a starting point for integrated dynamic assessments in future research endeavors. 5. Conclusion In conclusion, the study impeccably postulates an intrinsic-first rehabilitative strategy as a cornerstone in managing flexible flatfoot in children, with findings that could revolutionize current therapy protocols. The detailed investigation into the interrelationship between intrinsic and extrinsic muscle training offers a valuable lens through which future researches can refine and corroborate these results. It sets the stage for a new direction in therapeutic interventions—one that favors a bottom-up approach in musculoskeletal rehabilitation, aiming not only for symptomatic relief but also for the optimized structural and functional development of the foot. 4.1. Highlights The intrinsic-first strategy proved to positively influence the thickness and CSA of intrinsic foot muscles, specifically the ABH and FDB, without adversely affecting extrinsic foot muscle morphometry. Both the intrinsic- and extrinsic-first corrective exercise programs could reduce navicular drop, yet the intrinsic-first strategy proved to be more effective. Merely extrinsic muscle-focused corrective exercises can lead to the deterioration of intrinsic foot muscle morphometry. Abbreviations ABH Abductor hallucis CSA: Cross-sectional area FDB: Flexor digitorum brevis FDL: Flexor digitorum longus MLA: Medial longitudinal arch TA: Tibialis anterior TP: Tibialis posterior Declarations Acknowledgement Authors would like to appreciate participants. Author’s Contribution JK: Conceptualization, methodology, implementation, software, and writing the original draft. FS: Supervision, Project administration. SH: Supervision and implementation of tests. SF: participation in the design of the study and interpretation. YMT: project administration. FK: writing, substantial revision, and edition. All authors contributed to the manuscript writing. All authors have read and approved the final version of the manuscript, and agree with the order of presentation of the authors. Availability of data and materials All relevant data are included in the article. Funding Not applicable. Conflicts of interest/Competing interests No potential conflict of interests were reported by the authors. References El, O., et al., Flexible flatfoot and related factors in primary school children: a report of a screening study. Rheumatology international, 2006. 26 (11): p. 1050-1053. Mosca, V.S., Flexible flatfoot in children and adolescents. Journal of children's orthopaedics, 2010. 4 (2): p. 107-121. McKeon, P.O. and F. Fourchet, Freeing the foot: integrating the foot core system into rehabilitation for lower extremity injuries. Clinics in sports medicine, 2015. 34 (2): p. 347-361. Ridola, C. and A. Palma, Functional anatomy and imaging of the foot. Italian journal of anatomy and embryology= Archivio italiano di anatomia ed embriologia, 2001. 106 (2): p. 85-98. Kelly, L.A., et al., Intrinsic foot muscles have the capacity to control deformation of the longitudinal arch. Journal of The Royal Society Interface, 2014. 11 (93): p. 20131188. McKeon, P.O., et al., The foot core system: a new paradigm for understanding intrinsic foot muscle function. British journal of sports medicine, 2015. 49 (5): p. 290-290. Angin, S., et al., Ultrasound evaluation of foot muscles and plantar fascia in pes planus. Gait & posture, 2014. 40 (1): p. 48-52. Crofts, G., et al., Reliability of ultrasound for measurement of selected foot structures. Gait & posture, 2014. 39 (1): p. 35-39. Headlee, D.L., et al., Fatigue of the plantar intrinsic foot muscles increases navicular drop. Journal of Electromyography and Kinesiology, 2008. 18 (3): p. 420-425. Mickle, K.J., et al., Reliability of ultrasound to measure morphology of the toe flexor muscles. Journal of foot and ankle research, 2013. 6 (1): p. 1-6. Zhang, X., et al., Differences in foot muscle morphology and foot kinematics between symptomatic and asymptomatic pronated feet. Scandinavian Journal of Medicine & Science in Sports, 2019. 29 (11): p. 1766-1773. Taş, S., N.Ö. Ünlüer, and F. Korkusuz, Morphological and mechanical properties of plantar fascia and intrinsic foot muscles in individuals with and without flat foot. Journal of Orthopaedic Surgery, 2018. 26 (3): p. 2309499018802482. Jung, D.-Y., E.-K. Koh, and O.-Y. Kwon, Effect of foot orthoses and short-foot exercise on the cross-sectional area of the abductor hallucis muscle in subjects with pes planus: a randomized controlled trial. Journal of back and musculoskeletal rehabilitation, 2011. 24 (4): p. 225-231. Mulligan, E.P. and P.G. Cook, Effect of plantar intrinsic muscle training on medial longitudinal arch morphology and dynamic function. Manual therapy, 2013. 18 (5): p. 425-430. Richardson, C., P. Hodges, and J. Hides, Therapeutic exercise for lumbopelvic stabilization . Vol. 2004. 2004: Elsevier. Sulowska, I., et al., The influence of plantar short foot muscle exercises on foot posture and fundamental movement patterns in long-distance runners, a non-randomized, non-blinded clinical trial. PloS one, 2016. 11 (6): p. e0157917. Gooding, T.M., et al., Intrinsic foot muscle activation during specific exercises: a T2 time magnetic resonance imaging study. Journal of athletic training, 2016. 51 (8): p. 644-650. Brody, D.M., Techniques in the evaluation and treatment of the injured runner. The orthopedic clinics of north America, 1982. 13 (3): p. 541-558. Jung, D.-Y., et al., A comparison in the muscle activity of the abductor hallucis and the medial longitudinal arch angle during toe curl and short foot exercises. Physical Therapy in Sport, 2011. 12 (1): p. 30-35. Geideman, W.M. and J.E. Johnson, Posterior tibial tendon dysfunction. Journal of Orthopaedic & Sports Physical Therapy, 2000. 30 (2): p. 68-77. Kulig, K., et al., Selective activation of tibialis posterior: evaluation by magnetic resonance imaging. Medicine and science in sports and exercise, 2004. 36 (5): p. 862-867. Franettovich Smith, M.M., et al., New insights into intrinsic foot muscle morphology and composition using ultra‐high‐field (7-Tesla) magnetic resonance imaging. BMC Musculoskeletal Disorders, 2021. 22 (1): p. 1-14. Swanson, D.C., et al., Validity of ultrasound imaging for intrinsic foot muscle cross-sectional area measurements demonstrated by strong agreement with MRI. BMC Musculoskeletal Disorders, 2022. 23 (1): p. 146. Park, D.-J. and Y.-I. Hwang, Comparison of the intrinsic foot muscle activities between therapeutic and three-dimensional foot-ankle exercises in healthy adults: An explanatory study. International Journal of Environmental Research and Public Health, 2020. 17 (19): p. 7189. Jastifer, J.R., Intrinsic muscles of the foot: Anatomy, function, rehabilitation. Physical Therapy in Sport, 2023. Akuzawa, H., et al., Functional relationship between the foot intrinsic and extrinsic muscles in walking. Journal of Electromyography and Kinesiology, 2023. 71 : p. 102781. Péter, A., et al., EMG and force production of the flexor hallucis longus muscle in isometric plantarflexion and the push-off phase of walking. Journal of Biomechanics, 2015. 48 (12): p. 3413-3419. Sanchez-Gomez, R., et al., Muscle activity of the triceps surae with novel propulsion heel-lift orthotics in recreational runners. Orthopaedic Journal of Sports Medicine, 2020. 8 (10): p. 2325967120956914. Sudhakar, S., et al., WITHDRAWN: Efficacy of plantar short foot muscle exercise among middle distance runners: A single blind randomized controlled, pilot study . 2018, Elsevier. Chung, K.A., E. Lee, and S. Lee, The effect of intrinsic foot muscle training on medial longitudinal arch and ankle stability in patients with chronic ankle sprain accompanied by foot pronation. Physical Therapy Rehabilitation Science, 2016. 5 (2): p. 78-83. Lucas, R. and M. Cornwall, Influence of foot posture on the functioning of the windlass mechanism. The Foot, 2017. 30 : p. 38-42. Schünke, M., et al., Allgemeine Anatomie und Bewegungssystem : Prometheus LernAtlas der Anatomie . 2005: Stuttgart: Thieme Verlag. S. Fiolkowski, P., et al., Intrinsic pedal musculature support of the medial longitudinal arch: an Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 28 Dec, 2024 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 16 Jul, 2024 Reviews received at journal 10 Jul, 2024 Reviewers agreed at journal 25 Jun, 2024 Reviewers agreed at journal 24 Jun, 2024 Reviewers agreed at journal 14 May, 2024 Reviews received at journal 13 May, 2024 Reviewers agreed at journal 01 May, 2024 Reviewers invited by journal 29 Apr, 2024 Editor assigned by journal 24 Apr, 2024 Editor invited by journal 07 Mar, 2024 Submission checks completed at journal 07 Mar, 2024 First submitted to journal 21 Feb, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3974670","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":277937549,"identity":"7a2ba471-c54f-4a29-bf5e-6f648b244a47","order_by":0,"name":"Jafar Ketabchi","email":"","orcid":"","institution":"University of Tehran","correspondingAuthor":false,"prefix":"","firstName":"Jafar","middleName":"","lastName":"Ketabchi","suffix":""},{"id":277937550,"identity":"e2590d4a-e9db-4906-9373-f66a71840407","order_by":1,"name":"Foad Seidi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAzUlEQVRIiWNgGAWjYBAC9gYGBgkgYmwDsUCAjZAWngMwLTwHGBtI0cLA2CCRwNhAlMN42Jsf3vxRYSHbJ/nG/AFDjR0Dn/QBAlp4jhlb85yRMG6TzjFsYDiWzMDGl4Bfi71Egpk0Y5tEIkQL2wEGNh5CDpNI/yb58x9Qi+QZoJZ/RGnJMZPgbQBqkeAxbGBsI0YLz5lia55jQL/wpBXOSOxL5iGshb19480fNXWy89sPb/jw4ZudnHwPAS2oIAFoBkkaRsEoGAWjYBRgBwDGhDeNPlNS6gAAAABJRU5ErkJggg==","orcid":"","institution":"University of Tehran","correspondingAuthor":true,"prefix":"","firstName":"Foad","middleName":"","lastName":"Seidi","suffix":""},{"id":277937551,"identity":"f0b653ab-fac8-489c-a2d5-e2cf81ce9318","order_by":2,"name":"Shila Haghighat","email":"","orcid":"","institution":"Isfahan University of Medical Sciences","correspondingAuthor":false,"prefix":"","firstName":"Shila","middleName":"","lastName":"Haghighat","suffix":""},{"id":277937552,"identity":"3d6f4503-d056-4266-9d5d-b82491128238","order_by":3,"name":"Sue Falsone","email":"","orcid":"","institution":"A.T. Still University","correspondingAuthor":false,"prefix":"","firstName":"Sue","middleName":"","lastName":"Falsone","suffix":""},{"id":277937553,"identity":"4791c2e2-7c69-4788-8f68-89bdf3dc445d","order_by":4,"name":"Yousef Moghadas-Tabrizi","email":"","orcid":"","institution":"University of Tehran","correspondingAuthor":false,"prefix":"","firstName":"Yousef","middleName":"","lastName":"Moghadas-Tabrizi","suffix":""},{"id":277937554,"identity":"5b405822-bec0-4303-bc8d-7aaee113b7f7","order_by":5,"name":"Fatemeh Khoshroo","email":"","orcid":"","institution":"University of Tehran","correspondingAuthor":false,"prefix":"","firstName":"Fatemeh","middleName":"","lastName":"Khoshroo","suffix":""}],"badges":[],"createdAt":"2024-02-21 05:49:29","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3974670/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3974670/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41598-024-82970-y","type":"published","date":"2024-12-28T15:56:50+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":52455828,"identity":"dfa3b2ea-e476-4085-9f6e-01b0c1e237d3","added_by":"auto","created_at":"2024-03-11 19:57:30","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":135404,"visible":true,"origin":"","legend":"\u003cp\u003eDepiction of probe placement for ultrasonographic measurement: flexor digitorum longus thickness (A1-A2) and cross-sectional area (CSA) (A3-A4), flexor digitorum brevis thickness (B1-B2) and CSA (B3-B4), abductor hallucis thickness (C1-C2) and CSA (C3-C4), tibialis anterior thickness (D1-D2) and CSA (D3-D4), and tibialis posterior thickness (E1-E2) and CSA (E3-E4)\u003c/p\u003e","description":"","filename":"1.jpg","url":"https://assets-eu.researchsquare.com/files/rs-3974670/v1/e16faaeffabaf0e50c27cf57.jpg"},{"id":52455827,"identity":"b6ca9fba-0f44-4317-a50e-0892e47740e2","added_by":"auto","created_at":"2024-03-11 19:57:30","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":50685,"visible":true,"origin":"","legend":"\u003cp\u003eIllustration of intrinsic foot exercises: A) short foot exercise, B) extension of toes two to five, C) first toe extension, D) toe spreading\u003c/p\u003e","description":"","filename":"2.jpg","url":"https://assets-eu.researchsquare.com/files/rs-3974670/v1/105a7c3414d220bf427de9a7.jpg"},{"id":52456150,"identity":"c5ee5a7e-6dd9-4b51-9626-4fccef41791f","added_by":"auto","created_at":"2024-03-11 20:05:30","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":56626,"visible":true,"origin":"","legend":"\u003cp\u003eOverview of extrinsic exercises performed: A) foot adduction, B) heel raises, C) foot supination with an elastic band, D) foot inversion against gravity\u003c/p\u003e","description":"","filename":"3.jpg","url":"https://assets-eu.researchsquare.com/files/rs-3974670/v1/3f67239f1753baf89a3df3b5.jpg"},{"id":52456149,"identity":"9a68887e-10b9-41f0-8556-57da13884365","added_by":"auto","created_at":"2024-03-11 20:05:30","extension":"jpg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":83770,"visible":true,"origin":"","legend":"\u003cp\u003eIllustration of the variance in muscle thickness for both intrinsic and extrinsic exercise groups, from pre-test (before) to post-test (after 12 weeks): A) FDL, B) FDB, C) ABH, D) TA, E) tibialis posterior\u003c/p\u003e","description":"","filename":"4.jpg","url":"https://assets-eu.researchsquare.com/files/rs-3974670/v1/4fe364992a7ecaeddbd1f8e2.jpg"},{"id":52455831,"identity":"e905a49e-a407-4ed4-811e-03ac432b6ce2","added_by":"auto","created_at":"2024-03-11 19:57:30","extension":"jpg","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":17885,"visible":true,"origin":"","legend":"\u003cp\u003eIllustration of the variance in navicular drop for both intrinsic and extrinsic exercise groups, from pre-test (before) to post-test (after 12 weeks)\u003c/p\u003e","description":"","filename":"5.jpg","url":"https://assets-eu.researchsquare.com/files/rs-3974670/v1/c31bc9f9839ed77909931808.jpg"},{"id":52455830,"identity":"1f242fec-55e8-420a-851a-84d1884fe362","added_by":"auto","created_at":"2024-03-11 19:57:30","extension":"jpg","order_by":6,"title":"Figure 6","display":"","copyAsset":false,"role":"figure","size":88947,"visible":true,"origin":"","legend":"\u003cp\u003eIllustration of the variance in CSA for both intrinsic and extrinsic exercise groups, from pre-test (before) to post-test (after 12 weeks): \u0026nbsp;FDL (A), FDB (B), ABH (C), TA (D), and TP (E)\u003c/p\u003e","description":"","filename":"6.jpg","url":"https://assets-eu.researchsquare.com/files/rs-3974670/v1/1628c8bf08b5988827111425.jpg"},{"id":72640361,"identity":"76c7fdf5-f474-46e2-a777-75c18714ea8b","added_by":"auto","created_at":"2024-12-30 16:04:34","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1175682,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3974670/v1/df9fb25a-b057-495c-99f9-0f012836d3d3.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Differential Effects of Intrinsic- Versus Extrinsic-First Corrective Exercise Programs on Morphometric Outcomes and Navicular Drop in Pediatric Pes Planus","fulltext":[{"header":"1. Introduction","content":"\u003cp\u003eFlatfoot is a common pediatric foot abnormality [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e] characterized by a reduced medial longitudinal arch (MLA), and a consequential navicular drop [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. While various ligaments and fascia support the MLA, muscles also play an indispensable role in the maintenance of the MLA [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e], giving rise to a dichotomy: intrinsic versus extrinsic muscular groups [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. The intrinsic muscles such as the abductor hallucis (ABH) and flexor digitorum brevis (FDB), are anatomically situated with both origins and insertions in close proximity to the foot bones [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e]. These muscles are considered to be primary local stabilizers of the MLA by virtue of their small moment arms and intimate bone-to-bone tethering [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. Conversely, the extrinsic muscles\u0026mdash;tibialis anterior (TA), tibialis posterior (TP), and flexor digitorum longus (FDL)\u0026mdash;although extraneous to the foot in origin, provide vital reinforcement to the MLA [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. Their leverage positions these muscles as dynamic mobilizers, crucial for the generation of propulsive forces during locomotion [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. The nuanced collaborative mechanics of these muscle groups are integral to the sustainment of the MLA, thus accentuating the clinical pertinence of assessing their morphometry, namely thickness and CSA, as potential reflective markers for foot disorders such as flat feet [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. Nevertheless, there is a scarcity in the literature regarding detailed evaluations of the attributes of specific intrinsic and extrinsic foot muscles in cases of flatfoot [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eDisparities in the CSA of intrinsic and extrinsic foot muscles among populations with healthy versus pronated feet in adulthood [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e] imply potential morphometric remodifications, wherein extrinsic muscular adaptations are posited to compensate for intrinsic deficits [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. This adaptation suggested by the research of Angin et al. [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e], observing greater thickness and CSA in extrinsic foot muscles compared to intrinsic ones in individuals with pronated foot disorders, could potentially highlight a compensatory model of extrinsic-muscular hypertrophy in response to pronation stresses. Meanwhile, discrepancies in intrinsic muscle development between flat-footed individuals and their healthy counterparts have surfaced [\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e], fueling discussions on the role of exercises tailored to these muscles in preventing and potentially rectifying navicular drop [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e]. Jung et al. [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e] have reported that short foot exercises, combined with foot orthoses, can enhance the CSA of key intrinsic foot muscles like the ABH. Supporting this view, Mulligan and Cook [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e] have suggested that short foot exercises might be effective in preventing navicular drop by strengthening the intrinsic foot muscles.\u003c/p\u003e \u003cp\u003eThe concept of a \u0026lsquo;foot core system\u0026rsquo; [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e], extrapolated from Richardson and Hodges\u0026rsquo; lumbar stability model [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e], offers an innovative perspective through McKeon\u0026rsquo;s lens on foot musculature, conceptualizing intrinsic muscles as pivotal \u0026lsquo;local core stabilizers\u0026rsquo; countered by \u0026lsquo;global core stabilizers\u0026rsquo; represented by the extrinsic muscle cadre [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. This neurophysiological paradigm postulates that priming intrinsic muscles prior to their extrinsic counterparts may avert potential weakening of local musculature\u0026mdash;a principle that, if substantiated, could revolutionize the approach to foot muscle rehabilitation.\u003c/p\u003e \u003cp\u003eNoninvasive modalities such as corrective exercises, categorized by their focus on either intrinsic or extrinsic muscle groups, have gained prominence for their efficacy on the MLA [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. Contemporary literature on the intrinsic musculature of the foot lacks comparative exploration of intrinsic versus extrinsic muscle-focused training effects subject to different prioritizations on muscle morphometry [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e, \u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e]. Consequently, there needed to conduct an empirical study to figure out the muscular adaptations of the foot consequent to differential training methodologies. This study was hence designed to unravel the morphometric differences in selected intrinsic and extrinsic foot muscles contingent on the prioritization and timing of corrective exercises, and secondly, to ascertain the consequential variance in navicular drop amongst pediatric participants with flatfoot. It carries forward the hypothesis that initiation of corrective exercises with an extrinsic emphasis may inadvertently catalyze intrinsic muscle atrophy and exacerbate flatfoot deformities. The findings of this research endeavor aimed to illuminate the optimal sequencing of corrective exercises, potentially steering a new course for future therapeutic strategies in the management of flatfoot.\u003c/p\u003e"},{"header":"2. Methods","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003e2.1. Participants\u003c/h2\u003e \u003cp\u003e Ethical clearance was granted by the Faculty of Physical Education and Sport Sciences at the University of Tehran (IR.UT.SPORT.REC.1399.008) and the Iranian Registry of Clinical Trials (IRCT20210818052223N1 on 08/09/2021). Prospective interventional trial with a within-subject crossover design was used. For the study, twenty-five boys suffering from flexible flat feet were enlisted from elementary schools, ranging in age from 10 to 12 years. Informed consent was secured from their parents or legal guardians. All methods were carried out in accordance with the Declaration of Helsinki.\u003c/p\u003e \u003cp\u003eDuring the exercise intervention, three participants opted out of the study due to a lack of interest in continuing the collaboration with the researchers, which left twenty-two subjects. These remaining participants were randomly assigned to two groups: the intrinsic-first corrective exercise group (n\u0026thinsp;=\u0026thinsp;10, average age 10.8\u0026thinsp;\u0026plusmn;\u0026thinsp;0.78 years, height 138.8\u0026thinsp;\u0026plusmn;\u0026thinsp;7.22 cm, weight 40.7\u0026thinsp;\u0026plusmn;\u0026thinsp;9.49 kg) and the extrinsic-first corrective exercise group (n\u0026thinsp;=\u0026thinsp;12, average age 11\u0026thinsp;\u0026plusmn;\u0026thinsp;0.85 years, height 143.1\u0026thinsp;\u0026plusmn;\u0026thinsp;6.14 cm, weight 42.25\u0026thinsp;\u0026plusmn;\u0026thinsp;9.05 kg). Computer-generated randomization was used in a 1:1 ratio, followed by a masked allocation by opening the sequentially numbered, checkmate, and secured envelopes. A card inside each envelope indicated the group where the participant was randomly allocated, i.e. intervention or control groups.\u003c/p\u003e \u003cp\u003eCandidates for the study met inclusion criteria of having an orthopedist-diagnosed asymptomatic flexible flatfoot and a navicular drop test score of \u0026ge;\u0026thinsp;10 millimeters (mm). Exclusions were made for participants with any anatomical leg length discrepancies, a history of foot or leg surgery or injury, a diagnosis of structural flatfoot, a positive tarsal coalition test, current use of insole orthotics, or congenital lower extremity deformities such as genu valgum or femoral anteversion.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003e2.2. Protocol\u003c/h2\u003e \u003cp\u003eImages of the foot muscles, including the FDL, FDB, ABH, TA, and TP, were captured using an ultrasound system (US) (E-cube 9, Alpinion Medical Systems, Seoul, Korea) equipped with a 3\u0026ndash;10 MHz linear wideband array transducer. The evaluation was focused on the participants\u0026rsquo; dominant limb during stance\u0026mdash;the leg that each individual instinctively used when asked to perform a single-leg balance task. These assessments were carried out by a trained examiner blinded to group allocation, adhering to a methodology laid out by Crofts et al [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. For accurate muscle thickness measurement, the probe was meticulously aligned parallel to the muscle fibers. To determine the CSA, the probe was pivoted by 90 degrees to lie perpendicular to the fibers at the muscle\u0026rsquo;s thickest portion [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. In the pursuit of precision, the mean value derived from three separate measurements was taken for each muscle to ensure robust statistical analysis. Figure\u0026nbsp;\u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e1\u003c/span\u003e illustrates the probe positioning and sample images for all recorded measurements.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003e2.3. Measurement of navicular drop\u003c/h2\u003e \u003cp\u003eAccording to Brody\u0026rsquo;s methodology for the navicular drop test [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e], participants were seated with the hips, knees, and ankles at 90-degree angles and the tibia perpendicular to the floor. The examiner, blinded to group assignments, used the thumb and index finger to palpate the anteromedial and anterolateral aspects of the talus. The participant\u0026rsquo;s foot was rotated internally and externally to identify the subtalar joint\u0026rsquo;s neutral position, where the talus was palpably centered between the examiner\u0026rsquo;s fingers. The navicular bone\u0026rsquo;s height from the floor was measured in this position using a digital caliper. Following this, the participant stood, ensuring an equal distribution of body weight and a perpendicular tibia to the floor; the navicular height was measured again. The difference between seated and standing measurements provided the navicular drop value.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003e2.4. Intervention\u003c/h2\u003e \u003cp\u003eParticipants underwent a 12-week corrective exercise program, comprising three 45-minute sessions per week. The intrinsic-first group initially dedicated the first six weeks to performing exercises targeting the foot\u0026rsquo;s intrinsic muscles. Subsequently, for the latter half of the program, they switched to focusing on extrinsic muscle exercises. Conversely, the extrinsic group commenced with extrinsic muscle exercises for the initial six weeks and switched to intrinsic ones for the remaining six weeks of the program.\u003c/p\u003e \u003cdiv id=\"Sec7\" class=\"Section3\"\u003e \u003ch2\u003e2.4.1. Intrinsic foot exercises\u003c/h2\u003e \u003cp\u003eThe intrinsic foot exercise program commenced with non-weight-bearing (unloaded) exercises, such as sitting, and advanced to weight-bearing (loaded) scenarios such as standing and single-leg stances once muscle activation proficiency was achieved [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. Activities included short foot exercises, toe spreading, first toe extensions, and extensions of the second to fifth toes (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e2\u003c/span\u003e). Gooding et al. [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e] noted that these exercises led to heightened intrinsic muscle activation. Similarly, Jung et al. [\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e] found that short foot exercises elicited greater electromyographic activity in the ABH compared to conventional toe curls.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec8\" class=\"Section3\"\u003e \u003ch2\u003e2.4.2. Extrinsic foot exercise\u003c/h2\u003e \u003cp\u003eThe extrinsic foot exercise program was structured to activate and strengthen the extrinsic foot muscles, with a particular emphasis on the posterior tibialis muscle due to its critical function in supporting the MLA [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e]. It comprised exercises such as foot adduction, heel raises, and foot supination, which were performed both with an elastic band and against gravity, as illustrated in Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e3\u003c/span\u003e. Research by Kulig and colleagues [\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e] has demonstrated that the first three exercises are particularly effective in selectively engaging the extrinsic muscles of the foot, most notably the tibialis posterior. Initially, exercises were performed with minimal resistance, gradually incorporating heavier loads facilitated by an elastic band.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv id=\"Sec9\" class=\"Section2\"\u003e \u003ch2\u003e2.5. Statistical analysis\u003c/h2\u003e \u003cp\u003eData normality and variance homogeneity were ascertained using the Kolmogorov\u0026ndash;Smirnov test before comprehensive statistical evaluation. A two-way repeated measures ANOVA examined the group effects (intrinsic and extrinsic), time effects (initial, the 6th week, the 12th week), and interaction effects (Group \u0026times; Time) on the dependent variables of muscle thickness, CSA, and navicular drop. Bonferroni post hoc analysis was applied for pairwise comparisons at consecutive time points. P-values less than 0.05 were deemed statistically significant, with analyses performed using SPSS software (version 26.0; SPSS, Inc, an IBM Company, Chicago, IL).\u003c/p\u003e \u003c/div\u003e"},{"header":"3. Results","content":"\u003cp\u003eMixed ANOVA revealed significant interactions between the groups (Intrinsic, Extrinsic) and time (Initial, the 6th week, the 12th week) on the thickness of FDL (F\u003csub\u003e1,20\u003c/sub\u003e=9.43, P\u0026thinsp;=\u0026thinsp;0.002), FDB (F\u003csub\u003e1,20\u003c/sub\u003e=4.13, P\u0026thinsp;=\u0026thinsp;0.043), ABH (F\u003csub\u003e1,20\u003c/sub\u003e = 4.30, P\u0026thinsp;=\u0026thinsp;0.035), TA (F\u003csub\u003e1,20\u003c/sub\u003e = 5.16, P\u0026thinsp;=\u0026thinsp;0.013), and TP (F\u003csub\u003e1,20\u003c/sub\u003e = 4.36, P\u0026thinsp;=\u0026thinsp;0.021). A significant main effect of time was observed for the following muscles: FDB (F\u003csub\u003e1,20\u003c/sub\u003e=9.33, P\u0026thinsp;=\u0026thinsp;0.003), ABH (F\u003csub\u003e1,20\u003c/sub\u003e=6.52, P\u0026thinsp;=\u0026thinsp;0.010), TA (F\u003csub\u003e1,20\u003c/sub\u003e=6.31, P\u0026thinsp;=\u0026thinsp;0.006), and TP (F\u003csub\u003e1,20\u003c/sub\u003e=3.77, P\u0026thinsp;=\u0026thinsp;0.034). No significant effects were detected for group differences in all muscle variables related to thickness (p\u0026thinsp;\u0026gt;\u0026thinsp;0.05).\u003c/p\u003e \u003cp\u003eRegarding the CSA, significant interactions were found for FDL (F\u003csub\u003e1,20\u003c/sub\u003e=4.47, P\u0026thinsp;=\u0026thinsp;0.018), and ABH (F\u003csub\u003e1,20\u003c/sub\u003e=5.66, P\u0026thinsp;=\u0026thinsp;0.014). A significant main effect of time was observed for the following muscles: FDL (F\u003csub\u003e1,20\u003c/sub\u003e=3.26, P\u0026thinsp;=\u0026thinsp;0.04), FDB (F\u003csub\u003e1,20\u003c/sub\u003e=11.01, P\u0026thinsp;\u0026lt;\u0026thinsp;0.001), and TP (F\u003csub\u003e1,20\u003c/sub\u003e=3.69, P\u0026thinsp;=\u0026thinsp;0.034), indicating a temporal evolution in these measures. Conversely, no significant group effect\u003c/p\u003e \u003cp\u003eAdditionally, for navicular drop, a significant effect of time was noted (F\u003csub\u003e1,20\u003c/sub\u003e=55.65, P\u0026thinsp;\u0026lt;\u0026thinsp;0.001), while group and interaction effects did not reach statistical significance (p\u0026thinsp;\u0026gt;\u0026thinsp;0.05).\u003c/p\u003e \u003cp\u003eTables\u0026nbsp;\u003cspan refid=\"Tab1\" class=\"InternalRef\"\u003e1\u003c/span\u003e and \u003cspan refid=\"Tab2\" class=\"InternalRef\"\u003e2\u003c/span\u003e present the mean values, results of post hoc analyses, and the percentage of change in outcome measures from baseline to follow-ups at 6th and 12th weeks for both groups.\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab1\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 1\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eMean (SD) changes in navicular drop and the thickness of selected muscles from baseline to follow-ups at 6th and 12th weeks\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"11\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"char\" char=\"\u0026plusmn;\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cdiv align=\"char\" char=\"\u0026plusmn;\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e \u003cdiv align=\"char\" char=\"\u0026plusmn;\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c8\" colnum=\"8\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c9\" colnum=\"9\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c10\" colnum=\"10\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c11\" colnum=\"11\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e \u003cp\u003eVariable\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eGroup\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eInitial\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003e6th week\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003e12th week\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c6\"\u003e \u003cp\u003ep and % Change Initial to 6 weeks\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c7\"\u003e \u003cp\u003ep and % Change Initial to 12 weeks\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c8\"\u003e \u003cp\u003ep and % Change 6 weeks to 12 weeks\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c9\"\u003e \u003cp\u003eInteraction effect\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c10\"\u003e \u003cp\u003eTest time effect\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c11\"\u003e \u003cp\u003eGroup effect\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eFlexor digitorum longus (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.26\u0026thinsp;\u0026plusmn;\u0026thinsp;0.43\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.08\u0026thinsp;\u0026plusmn;\u0026thinsp;0.51\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e1.23\u0026thinsp;\u0026plusmn;\u0026thinsp;0.61\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.09\u003c/p\u003e \u003cp\u003e-14%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e-2%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.95\u003c/p\u003e \u003cp\u003e-14%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;9.34\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.002*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;3.07\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.077\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;2.26\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.148\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.42\u0026thinsp;\u0026plusmn;\u0026thinsp;0.40\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.79\u0026thinsp;\u0026plusmn;\u0026thinsp;0.52\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e1.20\u0026thinsp;\u0026plusmn;\u0026thinsp;0.50\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;\u0026lt;\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003e26%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.44\u003c/p\u003e \u003cp\u003e-15%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003e-33%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eFlexor digitorum brevis (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e0.72\u0026thinsp;\u0026plusmn;\u0026thinsp;0.23\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e0.71\u0026thinsp;\u0026plusmn;\u0026thinsp;0.36\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e0.78\u0026thinsp;\u0026plusmn;\u0026thinsp;0.33\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e-1%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e8%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e10%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;4.13\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.043*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;9.33\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.003*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;0.07\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.791\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e0.67\u0026thinsp;\u0026plusmn;\u0026thinsp;0.19\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e0.55\u0026thinsp;\u0026plusmn;\u0026thinsp;0.17\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e0.90\u0026thinsp;\u0026plusmn;\u0026thinsp;0.38\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.012\u003c/p\u003e \u003cp\u003e-18%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.026\u003c/p\u003e \u003cp\u003e34%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;\u0026lt;\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003e63%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eAbductor hallucis (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e0.81\u0026thinsp;\u0026plusmn;\u0026thinsp;0.24\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e0.91\u0026thinsp;\u0026plusmn;\u0026thinsp;0.37\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e0.94\u0026thinsp;\u0026plusmn;\u0026thinsp;0.40\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.48\u003c/p\u003e \u003cp\u003e12%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.85\u003c/p\u003e \u003cp\u003e16%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e3%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;4.30\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.035*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;6.52\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.010*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;1.50\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.234\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e0.73\u0026thinsp;\u0026plusmn;\u0026thinsp;0.23\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e0.58\u0026thinsp;\u0026plusmn;\u0026thinsp;0.14\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e0.95\u0026thinsp;\u0026plusmn;\u0026thinsp;0.36\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.07\u003c/p\u003e \u003cp\u003e-21%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.14\u003c/p\u003e \u003cp\u003e30%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;\u0026lt;\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003e64%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eTibialis anterior (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.87\u0026thinsp;\u0026plusmn;\u0026thinsp;0.41\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.74\u0026thinsp;\u0026plusmn;\u0026thinsp;0.44\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e2.06\u0026thinsp;\u0026plusmn;\u0026thinsp;0.58\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.78\u003c/p\u003e \u003cp\u003e-7%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.47\u003c/p\u003e \u003cp\u003e10%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.012\u003c/p\u003e \u003cp\u003e18%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;5.16\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.013*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;6.31\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.006*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;3.71\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.068\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.94\u0026thinsp;\u0026plusmn;\u0026thinsp;0.29\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e2.30\u0026thinsp;\u0026plusmn;\u0026thinsp;0.37\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e2.29\u0026thinsp;\u0026plusmn;\u0026thinsp;0.34\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.006\u003c/p\u003e \u003cp\u003e19%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.022\u003c/p\u003e \u003cp\u003e18%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e-0.5%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eTibialis posterior (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e2.07\u0026thinsp;\u0026plusmn;\u0026thinsp;0.33\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.92\u0026thinsp;\u0026plusmn;\u0026thinsp;0.39\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e2.29\u0026thinsp;\u0026plusmn;\u0026thinsp;0.54\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.72\u003c/p\u003e \u003cp\u003e-7%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.25\u003c/p\u003e \u003cp\u003e11%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.005\u003c/p\u003e \u003cp\u003e19%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;4.36\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.021*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;3.77\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.034*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;0.26\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.613\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e2.03\u0026thinsp;\u0026plusmn;\u0026thinsp;0.31\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e2.27\u0026thinsp;\u0026plusmn;\u0026thinsp;0.44\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e2.22\u0026thinsp;\u0026plusmn;\u0026thinsp;0.45\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.16\u003c/p\u003e \u003cp\u003e12%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.28\u003c/p\u003e \u003cp\u003e9%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e-2%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eNavicular Drop (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.54\u0026thinsp;\u0026plusmn;\u0026thinsp;0.45\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.12\u0026thinsp;\u0026plusmn;\u0026thinsp;0.32\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e0.81\u0026thinsp;\u0026plusmn;\u0026thinsp;0.26\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;\u0026lt;\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003e-27%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;\u0026lt;\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003e-47%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.003\u003c/p\u003e \u003cp\u003e-27%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;0.23\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.70\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;55.65\u003c/p\u003e \u003cp\u003eP˂0.001*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;0.77\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.391\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.64\u0026thinsp;\u0026plusmn;\u0026thinsp;0.58\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.25\u0026thinsp;\u0026plusmn;\u0026thinsp;0.40\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e1.00\u0026thinsp;\u0026plusmn;\u0026thinsp;0.34\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;\u0026lt;\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003e-24%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;\u0026lt;\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003e-39%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.01\u003c/p\u003e \u003cp\u003e-20%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cp\u003e*Indicates difference (P\u0026thinsp;\u0026lt;\u0026thinsp;.05).\u003c/p\u003e \u003cp\u003e \u003cdiv class=\"gridtable\"\u003e\u003ctable float=\"Yes\" id=\"Tab2\" border=\"1\"\u003e \u003ccaption language=\"En\"\u003e \u003cdiv class=\"CaptionNumber\"\u003eTable 2\u003c/div\u003e \u003cdiv class=\"CaptionContent\"\u003e \u003cp\u003eMean (SD) changes in the CSA of selected muscles from baseline to follow-ups at 6th and 12th weeks\u003c/p\u003e \u003c/div\u003e \u003c/caption\u003e \u003ccolgroup cols=\"11\"\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c1\" colnum=\"1\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c2\" colnum=\"2\"\u003e\u003c/div\u003e \u003cdiv align=\"char\" char=\"\u0026plusmn;\" class=\"colspec\" colname=\"c3\" colnum=\"3\"\u003e\u003c/div\u003e \u003cdiv align=\"char\" char=\"\u0026plusmn;\" class=\"colspec\" colname=\"c4\" colnum=\"4\"\u003e\u003c/div\u003e \u003cdiv align=\"char\" char=\"\u0026plusmn;\" class=\"colspec\" colname=\"c5\" colnum=\"5\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c6\" colnum=\"6\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c7\" colnum=\"7\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c8\" colnum=\"8\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c9\" colnum=\"9\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c10\" colnum=\"10\"\u003e\u003c/div\u003e \u003cdiv align=\"left\" class=\"colspec\" colname=\"c11\" colnum=\"11\"\u003e\u003c/div\u003e \u003cthead\u003e \u003ctr\u003e \u003cth align=\"left\" colname=\"c1\"\u003e \u003cp\u003eVariable\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c2\"\u003e \u003cp\u003eGroup\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c3\"\u003e \u003cp\u003eInitial\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c4\"\u003e \u003cp\u003e6th week\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c5\"\u003e \u003cp\u003e12th week\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c6\"\u003e \u003cp\u003ep and % Change Initial to 6 weeks\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c7\"\u003e \u003cp\u003ep and % Change Initial to 12 weeks\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c8\"\u003e \u003cp\u003ep and % Change 6 weeks to 12 weeks\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c9\"\u003e \u003cp\u003eInteraction effect\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c10\"\u003e \u003cp\u003eTest time effect\u003c/p\u003e \u003c/th\u003e \u003cth align=\"left\" colname=\"c11\"\u003e \u003cp\u003eGroup effect\u003c/p\u003e \u003c/th\u003e \u003c/tr\u003e \u003c/thead\u003e \u003ctbody\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eFlexor digitorum longus (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e2.52\u0026thinsp;\u0026plusmn;\u0026thinsp;2.28\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e2.43\u0026thinsp;\u0026plusmn;\u0026thinsp;2.17\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e2.68\u0026thinsp;\u0026plusmn;\u0026thinsp;2.03\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e-4%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e6%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.15\u003c/p\u003e \u003cp\u003e10%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;1.59\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.217\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;3.26\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.049*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;1.28\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.270\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.60\u0026thinsp;\u0026plusmn;\u0026thinsp;0.51\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.90\u0026thinsp;\u0026plusmn;\u0026thinsp;0.59\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e1.99\u0026thinsp;\u0026plusmn;\u0026thinsp;0.41\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.17\u003c/p\u003e \u003cp\u003e19%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.12\u003c/p\u003e \u003cp\u003e24%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e5%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eFlexor digitorum brevis (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.46\u0026thinsp;\u0026plusmn;\u0026thinsp;0.92\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.58\u0026thinsp;\u0026plusmn;\u0026thinsp;0.96\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e1.64\u0026thinsp;\u0026plusmn;\u0026thinsp;0.89\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.53\u003c/p\u003e \u003cp\u003e8%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.054\u003c/p\u003e \u003cp\u003e12%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e4%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;4.47\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.018*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;11.01\u003c/p\u003e \u003cp\u003eP˂0.001*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;0.08\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.786\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.42\u0026thinsp;\u0026plusmn;\u0026thinsp;0.57\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.31\u0026thinsp;\u0026plusmn;\u0026thinsp;0.66\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e1.68\u0026thinsp;\u0026plusmn;\u0026thinsp;0.55\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.55\u003c/p\u003e \u003cp\u003e-8%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003e18%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;\u0026lt;\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003e28%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eAbductor hallucis (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.34\u0026thinsp;\u0026plusmn;\u0026thinsp;0.59\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.59\u0026thinsp;\u0026plusmn;\u0026thinsp;0.80\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e1.60\u0026thinsp;\u0026plusmn;\u0026thinsp;0.80\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.15\u003c/p\u003e \u003cp\u003e18%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.21\u003c/p\u003e \u003cp\u003e19%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e1%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;5.66\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.014*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;1.61\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.219\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;0.04\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.854\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e1.55\u0026thinsp;\u0026plusmn;\u0026thinsp;0.55\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e1.29\u0026thinsp;\u0026plusmn;\u0026thinsp;0.52\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e1.53\u0026thinsp;\u0026plusmn;\u0026thinsp;0.55\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.09\u003c/p\u003e \u003cp\u003e-17%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e-1%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.006\u003c/p\u003e \u003cp\u003e18%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eTibialis anterior (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e5.80\u0026thinsp;\u0026plusmn;\u0026thinsp;1.86\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e5.26\u0026thinsp;\u0026plusmn;\u0026thinsp;1.77\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e5.65\u0026thinsp;\u0026plusmn;\u0026thinsp;2.00\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.164\u003c/p\u003e \u003cp\u003e-9%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e-3%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.18\u003c/p\u003e \u003cp\u003e7%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;2.03\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.145\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;1.29\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.286\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;0.001\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.978\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e5.68\u0026thinsp;\u0026plusmn;\u0026thinsp;1.51\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e5.68\u0026thinsp;\u0026plusmn;\u0026thinsp;1.20\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e5.40\u0026thinsp;\u0026plusmn;\u0026thinsp;1.06\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e0%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e-5%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.41\u003c/p\u003e \u003cp\u003e-5%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c1\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eTibialis posterior (cm)\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eIntrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e3.71\u0026thinsp;\u0026plusmn;\u0026thinsp;0.69\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e3.83\u0026thinsp;\u0026plusmn;\u0026thinsp;0.50\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e4.63\u0026thinsp;\u0026plusmn;\u0026thinsp;0.75\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e3%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.17\u003c/p\u003e \u003cp\u003e25%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.24\u003c/p\u003e \u003cp\u003e21%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c9\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;2.35\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.108\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c10\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;3.69\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.034*\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c11\" morerows=\"1\" rowspan=\"2\"\u003e \u003cp\u003eF\u0026thinsp;=\u0026thinsp;0.97\u003c/p\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.337\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003ctr\u003e \u003ctd align=\"left\" colname=\"c2\"\u003e \u003cp\u003eExtrinsic\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c3\"\u003e \u003cp\u003e4.08\u0026thinsp;\u0026plusmn;\u0026thinsp;1.56\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c4\"\u003e \u003cp\u003e4.94\u0026thinsp;\u0026plusmn;\u0026thinsp;1.88\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"char\" char=\"\u0026plusmn;\" colname=\"c5\"\u003e \u003cp\u003e4.59\u0026thinsp;\u0026plusmn;\u0026thinsp;1.68\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c6\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.008\u003c/p\u003e \u003cp\u003e21%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c7\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;0.72\u003c/p\u003e \u003cp\u003e13%\u003c/p\u003e \u003c/td\u003e \u003ctd align=\"left\" colname=\"c8\"\u003e \u003cp\u003eP\u0026thinsp;=\u0026thinsp;1.00\u003c/p\u003e \u003cp\u003e-7%\u003c/p\u003e \u003c/td\u003e \u003c/tr\u003e \u003c/tbody\u003e \u003c/colgroup\u003e \u003c/table\u003e\u003c/div\u003e \u003c/p\u003e \u003cp\u003e*Indicates difference (P\u0026thinsp;\u0026lt;\u0026thinsp;.05).\u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e \u003cp\u003e \u003c/p\u003e"},{"header":"4. Discussion","content":"\u003cp\u003eIn the investigation of intrinsic- versus extrinsic-first corrective exercise programs for pediatric flexible flatfoot, the current study adeptly explored the hypothesis that not only the kinds of exercises but also their sequence of implementation may significantly impact the morphometry of foot muscles and the degree of navicular drop. The study results indicated that intrinsic corrective exercises, like short foot exercises, during the initial six weeks for the intrinsic-first group led to an improvement in the muscle thickness and CSA of intrinsic muscles such as FDB (decrease of 1%, increase of 8%) and ABH (increase of 12%, 18%). These findings suggest that intrinsic-first strategy to the corrective exercise program does not adversely affect the morphometry of either intrinsic or extrinsic foot muscles. Even, subsequent implementation of extrinsic corrective exercises in the latter six-week period (from weeks 6 to 12) resulted in continued improvements in intrinsic foot muscles, evidenced by FDB (10%, 4%) and ABH (3%, 1%) gains in addition to enhanced muscle thickness and CSA of extrinsic muscles, including TA (18%, 7%) and TP (19%, 21%). In other words, training these muscles seems to provide a stable base for the extrinsic muscles to function more effectively. Hence, the initial focus on intrinsic muscle exercises not only exhibited a protective effect on the morphometry of these smaller muscles, but also extended benefits to the subsequent development of extrinsic muscles. This finding is a compelling endorsement of the foot core system theory, positing that a proximodistal approach to foot muscle rehabilitation may yield the most favorable outcomes in managing pediatric flatfoot [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eOur investigation also revealed that extrinsic corrective exercises during the initial six-week phase contributed to an adverse alteration in the morphometry of intrinsic muscles, while exerting beneficial effects on extrinsic musculature. Specifically, the muscle thickness and CSA of the intrinsic muscles, such as FDB (decreased by 18%, 8%) and ABH (decreased by 21%, 17%), exhibited declines, whereas the respective indices for extrinsic muscles, such as FDL (increased by 26%, 19%), TA (increased by 19%, unchanged), and TP (increased by 12%, 21%) incremented. This finding pivotally emphasized the potential negative impact of extrinsic-first strategy to the corrective exercise program. This sequence showed reduced morphometric benefits for the intrinsic muscles, a discovery that resonates with the foundational principles of neuromuscular rehabilitation, suggesting a potential interference effect where early extrinsic-muscle-training emphasis may overshadow intrinsic muscle development [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eIntrinsic corrective exercises in the following six-week period led to substantial enhancements in the thickness and CSA of the intrinsic muscles, evidenced by increments in FDB (63%, 28%) and ABH (64%, 18%). Contrary to lumbar stability model [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e], this intriguing result suggests that initiating training with the extrinsic foot muscles did not yield significantly different outcomes from commencing with intrinsic muscle emphasis. It should be noted that the six-week training period may not have been sufficient to fully differentiate the effects of training the intrinsic versus extrinsic foot muscles. Extending the duration of the training periods and incorporating longitudinal assessments could provide more comprehensive insights into the temporal dynamics of muscle adaptation in the lower extremities. Moreover, the divergence observed in the training sequence effects on foot musculature may stem from the distinct roles of the intrinsic foot muscles and the inner core unit. The intricate functions of the intrinsic foot muscles, specifically in supporting the foot arches and facilitating proper foot mechanics, may deviate from the sequential training efficacy proposed for the core musculature.\u003c/p\u003e \u003cp\u003eThe limited empirical researches in this field presents challenges to directly correlating current findings with established literature. Nevertheless, it appears that both intrinsic and extrinsic foot muscles follow a consistent response pattern to both extrinsic-muscle-targeted exercises and certain pathophysiological conditions. Notably, Angin et al. [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e] documented a decrease in the thickness and CSA of the ABH, flexor hallucis brevis, and the peronei longus and brevis, while reporting an increase in these metrics for the FDL and peronei muscles in flatfooted conditions. These findings suggest potential compensatory adaptation by the extrinsic muscles to uphold the MLA when intrinsic muscle functionality is compromised due to anomalous foot structure. The same compensatory response of extrinsic foot muscles\u0026mdash;the increase in thickness and CSA\u0026mdash;to both early extrinsic-muscle-training interventions over a controlled period and natural pathological conditions (i.e., flat feet) not only entails the adoption of more conscious intrinsic-first strategy to the corrective exercise program, but also seems to be indicative of a complex interplay between the intrinsic and extrinsic muscles, a phenomenon that can either support or undermine the structure and function of the foot, depending on the scenario.\u003c/p\u003e \u003cp\u003eThe results suggest a potential interference effect, where early emphasis on extrinsic muscle training may negatively impact the improvement of intrinsic muscles. Strengthening extrinsic foot muscles, which originate on the leg and insert on the foot, can potentially lead to intrinsic foot muscle atrophy due to a phenomenon known as \"muscle imbalance\" or \"disuse atrophy\" [\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. When extrinsic muscles are strengthened, they may take over the functions that intrinsic muscles typically perform, such as supporting the arch and aiding in foot movements. This can lead to underuse of the intrinsic muscles, which may then weaken and atrophy over time [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e]. When extrinsic muscles become stronger or more dominant, the intrinsic muscles may not receive the necessary stimulus to maintain their strength and function, leading to atrophy [\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eIt is also worth delving deeper into the anatomy underlying these observations. Intrinsic muscles, acting as local stabilizers, have shorter lever arms and are tailored for fine-tuned support of the MLA [\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. Indeed, intrinsic foot muscles have been shown to provide afferent information and a stable base of support for balance, changing the shape of the foot according to the loading [\u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e]. However, they are more prone to atrophy or functional impairment when not adequately prioritized in rehabilitative processes [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]. Conversely, training intrinsic foot muscles can play a crucial role in enhancing not only the intrinsic muscles but also the extrinsic muscles indirectly [\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e]. For instance, increased muscle activity in the intrinsic foot muscles has been associated with increased foot stiffness, which is beneficial for propulsion during gait [\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e] performed partly by TP [\u003cspan citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e].The enhancement of extrinsic muscle morphometry following intrinsic muscle training could suggest a neuromuscular adaptation that aligns with a foundational before functional training paradigm [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e]\u0026mdash;a concept embraced widely in core stabilization literature.\u003c/p\u003e \u003cp\u003eThe differential impact on the navicular drop\u0026mdash;a chief metric in assessing flatfoot severity\u0026mdash;furthers the discourse on the importance of exercise sequencing. Participants subjected to intrinsic muscle training showed a more substantial reduction in navicular drop (47%), though not statistically significant, compared to the extrinsic group (39%) over a 12-week training period, elevating the intrinsic-first strategy as a potentially superior strategy not only for muscle morphometry but also for functional foot correction.\u003c/p\u003e \u003cp\u003eNumerous studies have reported improvements in the stability of the MLA following the strengthening of the intrinsic foot muscles [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan citationid=\"CR29\" class=\"CitationRef\"\u003e29\u003c/span\u003e, \u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e]. Lucas et al. (2017) has asserted that exercises aimed at strengthening the intrinsic muscles of the foot are effective in enhancing the windlass mechanism and reducing the rate of navicular drop [\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e]. Although the primary factors affecting this mechanism are traditionally associated with the plantar fascia, the researchers believe that due to the extensive adhesions of the intrinsic foot muscles to the plantar fascia, strengthening these muscles could potentially increase tension in the fascia which in turn, may contribute to the improvement of the MLA, particularly during dynamic activities [\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e, \u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e]. During the gait cycle, substantial forces impact the foot and especially the MLA, thus strengthening the mechanism resistance to these forces can help the arch function as a stronger lever to maintain stability against external forces [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe interplay between foot structures and muscular function seem to further account for the way musculature influences foot configuration. Empirical studies suggest that the weakening of both extrinsic and intrinsic foot muscles, such as TP and ABH, precipitates a decrease in MLA height [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e]. Investigating static foot alignment through the navicular drop test and arch height index, Mulligan et al. [\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e] established that short-foot exercise yielded improvements within four weeks. Complementarily, Sulowska et al. [\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e] substantiated the positive effects of intrinsic muscle-strengthening exercises, reporting enhancement in the static foot alignment of long-distance runners after a six-week period of short-foot training, as assessed by the Foot Posture Index.\u003c/p\u003e \u003cp\u003eBased on findings, extrinsic-first muscle training also seems to significantly improve navicular drop. Considering the insertion points of the extrinsic muscles, particularly the TA and the TP muscles - the former attaching from above and the latter from the inferomedial aspect - it can be posited that these muscles may also exert considerable effects on controlling navicular drop. As such, no significant difference was observed between the two groups in terms of navicular drop. Therefore, it is deduced that both intrinsic and extrinsic muscles can contribute to the improvement of navicular drop and the control of foot pronation.\u003c/p\u003e \u003cp\u003eDespite the compelling findings, the study acknowledges several limitations\u0026mdash;including the sample size and the absence of physical activity control\u0026mdash;without which the external validity of these results may be circumscribed. Additionally, reliance on static foot measures like the navicular drop test as the sole outcome for foot structure change serves as a starting point for integrated dynamic assessments in future research endeavors.\u003c/p\u003e"},{"header":"5. Conclusion","content":"\u003cp\u003eIn conclusion, the study impeccably postulates an intrinsic-first rehabilitative strategy as a cornerstone in managing flexible flatfoot in children, with findings that could revolutionize current therapy protocols. The detailed investigation into the interrelationship between intrinsic and extrinsic muscle training offers a valuable lens through which future researches can refine and corroborate these results. It sets the stage for a new direction in therapeutic interventions\u0026mdash;one that favors a bottom-up approach in musculoskeletal rehabilitation, aiming not only for symptomatic relief but also for the optimized structural and functional development of the foot.\u003c/p\u003e \u003cp\u003e \u003cb\u003e4.1. Highlights\u003c/b\u003e \u003c/p\u003e \u003cp\u003e \u003col\u003e \u003cspan\u003e \u003cli\u003e \u003cp\u003eThe intrinsic-first strategy proved to positively influence the thickness and CSA of intrinsic foot muscles, specifically the ABH and FDB, without adversely affecting extrinsic foot muscle morphometry.\u003c/p\u003e \u003c/li\u003e \u003c/span\u003e \u003cspan\u003e \u003cli\u003e \u003cp\u003eBoth the intrinsic- and extrinsic-first corrective exercise programs could reduce navicular drop, yet the intrinsic-first strategy proved to be more effective.\u003c/p\u003e \u003c/li\u003e \u003c/span\u003e \u003cspan\u003e \u003cli\u003e \u003cp\u003eMerely extrinsic muscle-focused corrective exercises can lead to the deterioration of intrinsic foot muscle morphometry.\u003c/p\u003e \u003c/li\u003e \u003c/span\u003e \u003c/ol\u003e \u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eABH Abductor hallucis\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;CSA:\u0026nbsp;Cross-sectional area\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;FDB: Flexor digitorum brevis\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;FDL: Flexor digitorum longus\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;MLA: Medial longitudinal arch\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;TA: Tibialis anterior\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;TP: Tibialis posterior\u0026nbsp;\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgement\u0026nbsp;\u003c/strong\u003eAuthors would like to appreciate participants.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor\u0026rsquo;s Contribution\u0026nbsp;\u003c/strong\u003eJK: Conceptualization, methodology, implementation, software, and writing the original draft. FS: Supervision, Project administration. SH: Supervision and implementation of tests. SF: participation in the design of the study and interpretation. YMT: project administration. FK: writing, substantial revision, and edition.\u0026nbsp;All authors contributed to the manuscript \u0026nbsp;writing. All authors have read and approved the final version of the manuscript, and agree with the order of presentation of the authors.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e All relevant data are included in the article.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e Not applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflicts of interest/Competing interests\u003c/strong\u003e No potential conflict of interests were reported by the authors.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eEl, O., et al., \u003cem\u003eFlexible flatfoot and related factors in primary school children: a report of a screening study.\u003c/em\u003e Rheumatology international, 2006. \u003cstrong\u003e26\u003c/strong\u003e(11): p. 1050-1053.\u003c/li\u003e\n\u003cli\u003eMosca, V.S., \u003cem\u003eFlexible flatfoot in children and adolescents.\u003c/em\u003e Journal of children\u0026apos;s orthopaedics, 2010. \u003cstrong\u003e4\u003c/strong\u003e(2): p. 107-121.\u003c/li\u003e\n\u003cli\u003eMcKeon, P.O. and F. 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Lee, and S. Lee, \u003cem\u003eThe effect of intrinsic foot muscle training on medial longitudinal arch and ankle stability in patients with chronic ankle sprain accompanied by foot pronation.\u003c/em\u003e Physical Therapy Rehabilitation Science, 2016. \u003cstrong\u003e5\u003c/strong\u003e(2): p. 78-83.\u003c/li\u003e\n\u003cli\u003eLucas, R. and M. Cornwall, \u003cem\u003eInfluence of foot posture on the functioning of the windlass mechanism.\u003c/em\u003e The Foot, 2017. \u003cstrong\u003e30\u003c/strong\u003e: p. 38-42.\u003c/li\u003e\n\u003cli\u003eSch\u0026uuml;nke, M., et al., \u003cem\u003eAllgemeine Anatomie und Bewegungssystem : Prometheus LernAtlas der Anatomie\u003c/em\u003e. 2005: Stuttgart: Thieme Verlag. S.\u003c/li\u003e\n\u003cli\u003eFiolkowski, P., et al., \u003cem\u003eIntrinsic pedal musculature support of the medial longitudinal arch: an \u003c/em\u003e\u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"flatfoot, foot deformity, medial longitudinal arch","lastPublishedDoi":"10.21203/rs.3.rs-3974670/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3974670/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eAlthough the connection between muscular strength and flatfoot condition is well-established, the impact of corrective exercises on these muscles remains inadequately explored. This study aimed to assess the impact of intrinsic- versus extrinsic-first corrective exercise programs on muscle morphometry and navicular drop in boys with flexible flatfoot. Twenty-five boys aged 10–12 with flexible flatfoot participated, undergoing a 12-week corrective exercise program, with a shift in focus at six weeks. Ultrasound imaging measured muscle thickness and cross-sectional area (CSA), and the navicular drop test assessed flatfoot severity. The results demonstrated a significant interaction between exercise type and sequencing on muscle morphometry. Initiating with intrinsic exercises led to sustained improvement, even after transitioning to extrinsic exercises, while extrinsic-first exercises caused deterioration in intrinsic muscle morphology, which was recovered after transitioning to intrinsic exercises. Statistical analysis revealed significant improvements in muscle thickness and CSA over time, particularly when initiating intrinsic exercises first. The intrinsic-first group also exhibited a more pronounced reduction in navicular drop. In conclusion, initiating corrective exercises with intrinsic muscles proved more effective in improving foot muscle morphometry and reducing navicular drop in boys with flatfoot. Therefore, commencing correction with intrinsic muscle exercises is recommended before progressing to extrinsic muscle exercises.\u003c/p\u003e\n\u003cp\u003eIranian Registry of Clinical Trials (IRCT20210818052223N1) on 2021-09-08\u003c/p\u003e","manuscriptTitle":"Differential Effects of Intrinsic- Versus Extrinsic-First Corrective Exercise Programs on Morphometric Outcomes and Navicular Drop in Pediatric Pes Planus","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-03-11 19:57:25","doi":"10.21203/rs.3.rs-3974670/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-07-16T05:40:11+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-07-10T12:10:43+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"86097448072836032951456008800187016315","date":"2024-06-25T07:41:48+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"315837573088145019307162816015629132150","date":"2024-06-24T18:12:37+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"9050f565-c188-4a0b-b063-458d23348cca_SNPRID","date":"2024-05-14T04:42:55+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2024-05-13T13:46:52+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"c395c366-6049-4a2c-bc6d-26738e6eb7f8","date":"2024-05-01T14:40:12+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2024-04-29T14:11:20+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-04-24T09:30:50+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2024-03-07T16:07:41+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-03-07T16:05:54+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2024-02-21T05:46:34+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"1a390703-823f-4a05-8b98-b9c1e48da16f","owner":[],"postedDate":"March 11th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":29278606,"name":"Health sciences/Health care"},{"id":29278607,"name":"Health sciences/Health occupations"},{"id":29278608,"name":"Health sciences/Medical research"}],"tags":[],"updatedAt":"2024-12-30T15:58:30+00:00","versionOfRecord":{"articleIdentity":"rs-3974670","link":"https://doi.org/10.1038/s41598-024-82970-y","journal":{"identity":"scientific-reports","isVorOnly":false,"title":"Scientific Reports"},"publishedOn":"2024-12-28 15:56:50","publishedOnDateReadable":"December 28th, 2024"},"versionCreatedAt":"2024-03-11 19:57:25","video":"","vorDoi":"10.1038/s41598-024-82970-y","vorDoiUrl":"https://doi.org/10.1038/s41598-024-82970-y","workflowStages":[]},"version":"v1","identity":"rs-3974670","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3974670","identity":"rs-3974670","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}