Comparative Effectiveness of Bubble versus Ventilator-Derived Nasal Continuous Positive Airway Pressure on the Management of Transient Tachypnoea of the Newborn: A Retrospective Cohort Study in a Tertiary Care Hospital

Abstract Background Transient Tachypnoea of the Newborn (TTN) is a common cause of neonatal respiratory distress, often requiring respiratory support with Continuous Positive Airway Pressure (CPAP). This study compares the effectiveness of Bubble CPAP (BCPAP) and Ventilator-derived CPAP (VCPAP) in reducing NICU admissions in late preterm and term neonates with TTN. Materials and Methods This retrospective cohort study analysed 144 neonates born at or beyond 34 weeks' gestation with TTN who received either BCPAP (n = 70) or VCPAP (n = 74) in the delivery room. Outcomes included NICU admissions, length of hospital stay, intubation rates, surfactant use, and complications. Results There were no significant differences between the groups in NICU admissions (p > 0.05), hospital stay, intubation rates, or surfactant use. No cases of sepsis, necrotizing enterocolitis, or pneumothorax were observed. Conclusion Both BCPAP and VCPAP were equally effective in managing TTN, with no notable difference in clinical outcomes or safety. Further prospective studies are required to validate these findings.