How understudied endometriosis causes pain for hundreds of millions of women

Heidi Ledford, Ledford H
Nature · 2024 · doi:10.1038/d41586-024-03628-3 · PMID:39506178 · W4404097890
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This paper explores the understudied mechanisms by which endometriosis causes pain in hundreds of millions of women globally.

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This news brief highlights a study published in Science Translational Medicine that investigates the mechanisms behind pain in endometriosis, a condition affecting an estimated 190 million women globally. The research utilized mouse models to demonstrate how pain-sensing nerves and immune cells interact to drive the disorder's painful symptoms. By understanding this specific cellular crosstalk, the authors suggest potential new avenues for therapeutic intervention targeting these interactions rather than just the lesions themselves. This paper is centrally about endometriosis — specifically exploring the neuro-immune interactions that cause chronic pelvic pain associated with the disease.

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- NEWS How understudied endometriosis causes pain for hundreds of millions of women Pain-sensing nerves and immune cells work together to wreak havoc in endometriosis, a painful condition that affects an estimated 190 million women and girls of reproductive age. But a study in mice suggests a way to harness that interaction to treat the disorder1. Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 € / 30 days cancel any time Subscribe to this journal Receive 52 print issues and online access 185,98 € per year only 3,58 € per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout doi: https://doi.org/10.1038/d41586-024-03628-3 References Fattori, V. et al. Sci. Transl. Med. 16, eadk8230 (2024). Garcia Garcia, J. M. et al. Reprod. Sci. 30, 1453–1461 (2023).

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endometriosis

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