Numerical Simulation of Fluid-Structure Interaction between Aqueous Humor and Implantable Collamer Lens

Purpose: This paper aims to study the Implantable Collamer Lens (ICL) stability under the action of intraocular aqueous humor (AH), consider the influence of different parameters on both, and quantify the threshold of ICL deformation. Methods The numerical Fluid-Structure Interaction (FSI) method was used to calculate the AH flow field and the deformation of the ICL. This paper considers the effects of different gravity directions and intraocular temperature differences on AH flow and ICL deformation. Results Implantation of the ICL changes the distribution of the AH, and more than 90% of the AH flows into the anterior chamber (AC) through the central hole of the ICL. The average velocity of the AH is highest when looking flat, reaching 2.59e-2mm/s, which is about 3.5 times higher than when looking up and down. The greater the temperature difference within the eye, the higher the average AH flow rate. The maximum deformation of the ICL occurs at its central hole, which is in the order of e-4mm. The deformation of the ICL reaches a maximum of 5.41e-4mm in the downward view, which is four times and 1.7 times that in the upward and flat views, respectively. The influence of intraocular temperature difference on the deformation of ICL is about e-4mm. The amount of ICL deformation was negatively correlated with the average pressure generated by AH. Conclusion ICL implantation is a safe and effective way to correct myopia. Patient posture and ambient temperature had little effect on the deformation of the ICL.