Discussion
‘In 1564, Leonardi Botali, an Italian surgeon, was the first to describe the presence of foramen ovale at birth.’ 2 Patent foramen ovale is a source of paradoxical embolism, and it was described by Cohneim in 1877. 2 The RECO study group later found that 45% of central retinal artery occlusion patients under 45 years had cardiac abnormalities, of whom 27% needed anticoagulation or cardiac surgery. 3
‘Patent foramen ovale is a flap-like opening between the atrial septa primum and secundum at the location of the fossa ovalis that persists after age of 1 year.’ 2 In utero, the foramen ovale serves as a physiologic conduit for right-to-left shunting. Once the pulmonary circulation is established after birth, left atrial pressure increases, allowing functional closure of the foramen ovale. This is followed by anatomical closure of the septum primum and septum secundum by the age of 1 year.
With increasing evidence that patent foramen ovale is the culprit in paradoxical embolic events. James Lock postulated that the patent foramen ovale anatomy results in a cul-de-sac between the thin septa primum and thick septum secundum, 4 predisposing individuals to haemostasis and clot formation. 2 Any conditions that increase right atrial pressure more than left atrial pressure can induce paradoxical flow and may result in an embolic event. 4
Our patient was 10 weeks pregnant, at the time of presentation. Retinal artery occlusion can occur in pregnancy due to an induced hypercoagulable state. During pregnancy, clotting is altered by a 50% increase in fibrinogen, increases in coagulation factors II, VII, VIII, IX and X, decreases in prothrombin and partial thromboplastin time, decreased fibrinolytic activity and stasis of blood in the lower half of the body. Because the retinal artery obstruction occurred so early in pregnancy, another mechanism can be proposed. This occlusion may represent a paradoxical embolism in the form of amniotic fluid from the uterine vessels passing through the patent foramen ovale to the retinal artery with activation of complement and granulocyte aggregation.
Patients with patent foramen ovale and paradoxical embolism are at increased risk of recurrent systemic thromboembolic events, ranging from 3.2% to 3.8% per year. The optimal management of these patients remains controversial. Long-term anticoagulation, surgical patent foramen ovale closure and percutaneous transcatheter closure of the patent foramen ovale have been proposed as therapeutic options. 1 Transcatheter techniques to close patent foramen ovale have been used with increasing frequency during the last few years.
It is important to consider a diagnosis of a patent foramen ovale, when there is a young patient presenting with a retinal artery occlusion. 5 A multisystem examination is required and prophylactic measures need to be taken against systemic thromboembolic disease.