Multiple primary synchronous tumor: сancer of the cecum and borderline ovarian tumor with congenital uterine malformation (clinical observation)

А. В. Герасимов, S. E. Krasilnikov, А. Г. Кедрова, С. А. Фурсов, Н. М. Колотова, V. Е. Voitsitsky
In: Tumors of female reproductive system · 2017 · vol. 13(1) , pp. 59–63 · doi:10.17650/1994-4098-2017-13-1-59-63 · W2611817651
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Abstract

The article presents a clinical observation of a combination of multiple primary tumors: cancer of the cecum, mixed Müllerian atypical proliferative (borderline) tumors, atypical hyperplasia of the uterus endometrium with uterus didelphys. A rare combination of uterine malformation at the organogenesis stage suggests presence of ectopic Müllerian epithelium in different tissues, where, due to various reasons, notably endometriosis and metabolic disorders, cancerogenic mutations may quickly accumulate. Active metaplasia of ectopic epithelium serves as a favorable medium for microsatellite instability and several pathways of atypical proliferation. This increases the risk of development of multipleprimary tumors.
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Multiple primary synchronous tumor: сancer of the cecum and borderline ovarian tumor with congenital uterine malformation (clinical observation) - Authors: Gerasimov A.V.1, Krasilnikov S.E.1, Kedrova A.G.2, Fursov S.A.1, Kolotova N.M.1, Voitsitsky V.E.1 - Affiliations: - Novosibirsk State Regional Clinical Oncologic Dispensary - Institute for Advanced Training, Federal Medical and Biological Agency - Issue: Vol 13, No 1 (2017) - Pages: 59-63 - Section: GYNECOLOGY. ORIGINAL REPORTS - Published: 06.05.2017 - URL: https://ojrs.abvpress.ru/ojrs/article/view/536 - DOI: https://doi.org/10.17650/1994-4098-2017-13-1-59-63 - ID: 536 Cite item Full Text Abstract primary tumors. About the authors A. V. Gerasimov Novosibirsk State Regional Clinical Oncologic Dispensary Author for correspondence. Email: [email protected] Russian Federation S. E. Krasilnikov Novosibirsk State Regional Clinical Oncologic DispensaryRussian Federation A. G. Kedrova Institute for Advanced Training, Federal Medical and Biological AgencyRussian Federation S. A. Fursov Novosibirsk State Regional Clinical Oncologic DispensaryRussian Federation N. M. Kolotova Novosibirsk State Regional Clinical Oncologic DispensaryRussian Federation V. E. Voitsitsky Novosibirsk State Regional Clinical Oncologic DispensaryRussian Federation

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