Multiple primary synchronous tumor: сancer of the cecum and borderline ovarian tumor with congenital uterine malformation (clinical observation)

А. В. Герасимов, S. E. Krasilnikov, А. Г. Кедрова, С. А. Фурсов, Н. М. Колотова, V. Е. Voitsitsky
In: Tumors of female reproductive system · 2017 · vol. 13(1) , pp. 59–63 · doi:10.17650/1994-4098-2017-13-1-59-63 · W2611817651
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Abstract

The article presents a clinical observation of a combination of multiple primary tumors: cancer of the cecum, mixed Müllerian atypical proliferative (borderline) tumors, atypical hyperplasia of the uterus endometrium with uterus didelphys. A rare combination of uterine malformation at the organogenesis stage suggests presence of ectopic Müllerian epithelium in different tissues, where, due to various reasons, notably endometriosis and metabolic disorders, cancerogenic mutations may quickly accumulate. Active metaplasia of ectopic epithelium serves as a favorable medium for microsatellite instability and several pathways of atypical proliferation. This increases the risk of development of multipleprimary tumors.

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endometriosis

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last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK