The causal relationship between sleep characteristics and skin pigmentation abnormalities based on two-sample Mendelian randomization

The causal relationship between sleep characteristics and skin pigmentation abnormalities based on two-sample Mendelian randomization | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The causal relationship between sleep characteristics and skin pigmentation abnormalities based on two-sample Mendelian randomization Yang Liu, Yun Pu, Qiao Kang, Qing Zhao, Xinming Chen, Feng wan Liao, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4661417/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 4 You are reading this latest preprint version Abstract Objective To study whether there is a causal association between sleep characteristics and abnormalities of skin pigmentation (Skin pigmentation). Methods Two-sample Mendelian randomization method (MR) using published genome-wide association studies to obtain related exposure factors (SNPs) of sleep characteristics (sleep type, sleep duration) as instrumental variables, MR-gger, weighted median, inverse variance weighted (IVW) random effect model to study the causal effect of sleep characteristics on the risk of skin pigmentation, and MR-Egger sensitivity analysis to verify the reliability of the data. Results: There is a causal relationship between sleep type and abnormal skin pigmentation, different from intermediate type, with obvious preference characteristics: early go to bed, early or late onset will significantly increase the risk of skin pigmentation as a risk factor for skin pigmentation. [IVW random effect model: OR = 1.026,95%CI (1.011,1.041), P =0.001, P <0.05]. However, there was no causal relationship between skin pigmentation and sleep duration. Conclusion: Sleep time type (early / late) may increase the incidence of skin pigmentation, with sleep type (early / late) and skin pigmentation. sleep type sleep duration Mendelian randomization skin pigmentation causal association Full Text Additional Declarations No competing interests reported. Supplementary Files Appendixtothearticle.zip Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 15 Jul, 2024 Editor assigned by journal 02 Jul, 2024 Submission checks completed at journal 02 Jul, 2024 First submitted to journal 30 Jun, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4661417","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":327397054,"identity":"01a42150-3ca6-4c48-9eff-ed07ffa82e43","order_by":0,"name":"Yang 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abnormalities based on two-sample Mendelian randomization","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"archives-of-dermatological-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"Learn more about [Archives of Dermatological Research](https://www.springer.com/journal/403)","snPcode":"403","submissionUrl":"https://submission.nature.com/new-submission/403/3","title":"Archives of Dermatological Research","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"sleep type, sleep duration, Mendelian randomization, skin pigmentation, causal association","lastPublishedDoi":"10.21203/rs.3.rs-4661417/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4661417/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eObjective To study whether there is a causal association between sleep characteristics and abnormalities of skin pigmentation (Skin pigmentation).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMethods Two-sample Mendelian randomization method (MR) using published genome-wide association studies to obtain related exposure factors (SNPs) of sleep characteristics (sleep type, sleep duration) as instrumental variables, MR-gger, weighted median, inverse variance weighted (IVW) random effect model to study the causal effect of sleep characteristics on the risk of skin pigmentation, and MR-Egger sensitivity analysis to verify the reliability of the data.\u003c/p\u003e\n\u003cp\u003eResults: There is a causal relationship between sleep type and abnormal skin pigmentation, different from intermediate type, with obvious preference characteristics: early go to bed, early or late onset will significantly increase the risk of skin pigmentation as a risk factor for skin pigmentation. [IVW random effect model: OR = 1.026,95%CI (1.011,1.041), P =0.001, P \u0026lt;0.05]. However, there was no causal relationship between skin pigmentation and sleep duration.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eConclusion: Sleep time type (early / late) may increase the incidence of skin pigmentation, with sleep type (early / late) and skin pigmentation.\u003c/p\u003e","manuscriptTitle":"The causal relationship between sleep characteristics and skin pigmentation abnormalities based on two-sample Mendelian randomization","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-07-24 19:49:19","doi":"10.21203/rs.3.rs-4661417/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Revision requested","date":"2024-07-16T00:22:21+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2024-07-02T12:24:39+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2024-07-02T12:24:27+00:00","index":"","fulltext":""},{"type":"submitted","content":"Archives of Dermatological Research","date":"2024-06-30T06:05:15+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"archives-of-dermatological-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"Learn more about [Archives of Dermatological Research](https://www.springer.com/journal/403)","snPcode":"403","submissionUrl":"https://submission.nature.com/new-submission/403/3","title":"Archives of Dermatological Research","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"58a8bbd3-b364-4133-9d18-324775a166ce","owner":[],"postedDate":"July 24th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2024-11-18T22:23:25+00:00","versionOfRecord":[],"versionCreatedAt":"2024-07-24 19:49:19","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4661417","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4661417","identity":"rs-4661417","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}