The impact of endometriosis towards the severity of anemia

The impact of endometriosis towards the severity of anemia DOI: https://doi.org/10.54957/ijhs.v5i4.1597Kata Kunci: Anemia, Endometriosis, Iron deficiencyAbstrak The purpose of this study was to investigate the relationship between endometriosis and anemia severity, along with other potential contributing factors. The study was conducted at Margono Hospital in Indonesia and involved patients with endometriosis who were enrolled from 2020 to 2024. Inclusion and exclusion criteria were applied, and statistical analyses, including odds ratios and prevalence ratios, were performed. The analysis revealed that women of reproductive age were significantly more likely to develop endometriosis, with an odds ratio of 3.033 [95% CI 1.703-5.403, p<0.001]. Increasing age contributed 0.9% to the likelihood of endometriosis, and parity was significantly associated with endometriosis, with nulliparous women having an odds ratio of 11.883 [95% CI 2.103-67.163, p<0.001]. No significant correlation was found between anemia severity and endometriosis, though moderate anemia was most likely in the case group [OR 0.744, 95% CI 0.520-1.063, p=0.613]. Although endometriosis did not significantly affect anemia severity in our study, further research is needed to explore the molecular impact of different types of endometriosis on erythropoiesis. Referensi Atkins, H. M., Susan, E. A., Taylor, R. N., Mendoza, Y. T., Lenk, E., & Rosenthal, N. S. (2018). Systemic Iron Deficiency in a Nonhuman Primate Model of Endometriosis. Journal of Comparative Medicine, 64(4), 298–307. Bilotas, M. A., Olivares, C. N., Ricci, A. G., Baston, J. I., Bengochea, T. S., Meresman, G. F. (2015). Interplay between Endometriosis and Pregnancy in a Mouse Model. PLOS ONE. Cho, H. Y., Park, S. T., & Park, S. H. (2024). Red blood cell indices as an effective marker for the existence and severity of endometriosis (STROBE). Medicine Open Access Journal, 101(42). Christopher, S., & Donovan, C. (2023). Improving the diagnosis of endometriosis in Asia-Pacific: Consensus from the Asia-Pacific Endometriosis Expert Panel for Endometriosis. Wiley Bayer. Dereje, G. G., Jenny, D., Sally, M., Grant, M., & Gita, D. (2024). Risk of Iron Deficiency in Women With Endometriosis: A Population-Based Prospective Cohort Study. Women’s Health Issues, 34(3). Feng, J., Zhang, S., Chen, J., Zhu, J., & Yang, J. (2022). Global Burden of Endometriosis in 204 Countries and Territories from 1990 to 2019. Clinical and Experimental Obstetric & Gynecology, 49(10). James, W., Fernando, S. M., Powell, S. G., Hill, C. J., Arshad, I., & Probert, C. (2023). The role of iron in the pathogenesis of endometriosis: a systematic review. Human Reproductive Open Journal, 3. Kvaskoff, M., Mu, F., Terry, K. L., & Harris, H. R. (2015). Endometriosis: A High-Risk Population for Major Chronic Disease? Human Reproduction Update, 21(4), 1–17. Li, Y., He, Y., Cheng, W., Zhou, Z., Ni, Z., & Yu, C. (2023). Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility. Cell Death Discovery Journal, 22(9). Ranjan, Y. S., Ziauddeen, N., Stuart, B., & Alwan, N. (2023). The role of parity in the relationship between endometriosis and pregnancy outcomes. Reproduction and Fertility Open Access Journal, 4(1). Saunders, P. T. K., & Horne, A. W. (2021). Endometriosis: Etiology, pathobiology, and therapeutic prospects. Cell, 184(11), 2807–2824. https://doi.org/10.1016/j.cell.2021.04.041 Vercellini, P., Vigano, P., Somigliana, E., & Fedele, L. (2014). Endometriosis : Pathogenesis and Treatment. Nature Reviews Endocrinology, 10, 261–275. World Health Organization. (2024). Guideline on Haemoglobin Cutoffs to Define Anaemia in Individuals and Populations. Zhang, S., Gong, T. T., Wang, H. Y., Zhao, Y. H., and Wu, Q. J. (2021). Global, Regional, And National Endometriosis Trends From 1990 to 2017. Annals of the New York Academy of Sciences, 1484(1), 90–101. Zondervan, K. T., Becker, C. M., & Missmer, S. A. (2020). Endometriosis. The New England Journal of Medicine, 382, 1244–1256. Unduhan Diterbitkan Cara Mengutip Terbitan Bagian Lisensi Hak Cipta (c) 2025 Salsa Evva Nurjanah, Ira Citra Ningrom, Mustika Ratnaningsih Purbowati, Norina Agatri, Megawati Al’badly Ponco Dewi Poernomo, Dina Marlina, Aditya Utomo, Beni Samsul Amri Artikel ini berlisensi Creative Commons Attribution 4.0 International License.