Ephaptic coupling distance between myelinated axons is not static but a dynamic function of neural code and axonal plasticity

Ephaptic coupling distance between myelinated axons is not static but a dynamic function of neural code and axonal plasticity | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Ephaptic coupling distance between myelinated axons is not static but a dynamic function of neural code and axonal plasticity Koushik Maharatna, Sarbani Das, Mariana Vargas-Caballero This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4550191/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract In this paper, using resistor-capacitor modelling, for the first time we established a generalised theoretical framework to quantitatively characterise the governing parameters for inducing Action Potential (AP) from one myelinated axon to another via Ephaptic Coupling (EC) phenomenon. Analyses of the model showed that the EC distance is a dynamic function of (1) the instantaneous frequency of the AP train, which in essence represents a neural code, in the driving fibre, (2) the (mis)alignment of the Nodes of Ranvier (NR) between the driving and the driven fibre, and 3) the radii of the driving and the driven NR. The last two factors are intrinsically related to axonal plasticity that takes effect at a longer timescale compared to the first factor. We also showed that a driving NR can induce AP to a maximum of 6 NRs in a homogeneous nerve bundle while in a heterogeneous nerve bundle AP could be induced by one NR to another if the radius of the driven NR is less than 6-times the radius of the driving NR. The set of rules developed in this work gives an objective guideline for (1) understanding how a neural code transmitted by a neural population to another could get modified during its propagation via a nerve bundle connecting them such as, the White Matter Tracts and Spinal Nerves, and 2) selecting appropriate stimulation parameters to dynamically modify neural codes in a nerve bundle for treating various nerve disorders. Biological sciences/Neuroscience/Computational neuroscience Biological sciences/Computational biology and bioinformatics Biological sciences/Neuroscience Physical sciences/Nanoscience and technology Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4550191","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":333294841,"identity":"c18de7d8-4c83-4fd2-8475-b18517860d22","order_by":0,"name":"Koushik Maharatna","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA00lEQVRIiWNgGAWjYBACCQb2gw/QxNgIaeFJNoAwmYnWwmAmQZoWyWkH0io+1NQxyLf3H3xcwGAnzyCRloBXi7R04rGbM44dZjA4c5jZeAZDsmGDRNoBvFrkpBPSbvM2HGAwkEhmk+ZhYE5gkEhvIKTFrPhvA9BhM8Ba6glrkQZqYWZsAHr9BljLYaAWAg6TnJ2TLNlz7DAP0C/GxjwGxw3beJ4l4NUicTv94IcfNXVy8u2NDx/zVFTL87OnGeDVAgM8EMqAYKyMglEwCkbBKCAGAACu2zjG4TCVeQAAAABJRU5ErkJggg==","orcid":"","institution":"University of Southampton","correspondingAuthor":true,"prefix":"","firstName":"Koushik","middleName":"","lastName":"Maharatna","suffix":""},{"id":333294842,"identity":"2cee9b88-0a2c-4bae-b434-cdfc13757c6b","order_by":1,"name":"Sarbani Das","email":"","orcid":"","institution":"University of Southampton","correspondingAuthor":false,"prefix":"","firstName":"Sarbani","middleName":"","lastName":"Das","suffix":""},{"id":333294843,"identity":"4f87fc72-d804-44bd-92f0-21d70d95bc72","order_by":2,"name":"Mariana Vargas-Caballero","email":"","orcid":"","institution":"University of Southampton","correspondingAuthor":false,"prefix":"","firstName":"Mariana","middleName":"","lastName":"Vargas-Caballero","suffix":""}],"badges":[],"createdAt":"2024-06-08 10:38:16","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4550191/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4550191/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":65115390,"identity":"140e6e43-71ec-4e9e-a185-fbf427b7020e","added_by":"auto","created_at":"2024-09-23 19:31:46","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1200411,"visible":true,"origin":"","legend":"","description":"","filename":"ephaphticMVC.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4550191/v1_covered_0254649e-9c11-4667-8088-182d7e605851.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Ephaptic coupling distance between myelinated axons is not static but a dynamic function of neural code and axonal plasticity","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-4550191/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4550191/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eIn this paper, using resistor-capacitor modelling, for the first time we established a generalised theoretical framework to quantitatively characterise the governing parameters for inducing Action Potential (AP) from one myelinated axon to another via Ephaptic Coupling (EC) phenomenon. 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