Time to improvement in semen parameters after microsurgical varicocelectomy in men with severe oligospermia

Masterson TA, Thomas A. Masterson, Aubrey B Greer, Greer AB, Ranjith Ramasamy
Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2019 · vol. 13(3) , pp. E66–E69 · doi:10.5489/cuaj.5408 · PMID:30169150 · PMC6395104
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This study evaluated semen parameter improvement after microsurgical varicocelectomy in men with severe oligospermia, finding significant increases in total motile sperm count at three to six months and identifying preoperative counts above two million as predictive of quality upgrading.

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This study evaluated the timeline and predictive factors for semen quality improvement in 33 men with severe oligospermia following microsurgical varicocelectomy. Results indicated that total motile sperm count significantly increased from baseline to 3–6 months post-surgery, with minimal additional improvement observed after six months. The research found that a preoperative total motile sperm count between 2 and 5 million was the most significant predictor of upgrading semen quality to levels permitting natural pregnancy. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

INTRODUCTION: We aimed to determine the time and predictive factors of semen quality improvement in men with severe oligospermia after microsurgical varicocelectomy. METHODS: Men with total motile sperm count (TMSC) 6 months. We evaluated preoperative factors for successful semen quality upgrading based on assisted reproductive technology (ART) eligibility: in vitro fertilization [IVF] (9 million). We compared men with TMSC 6 months postoperatively RESULTS: A total of 33 men were included. TMSC improved from 1.5±0.2 to 7.3±1.8 million at 3-6 months (p6 months (p6 months. Sixteen (48.5%) men upgraded semen quality into the range of natural pregnancy. Preoperative TMSC from 2-5 million was predictive of upgrading semen quality. Twenty-four couples were contacted by phone; 20 were attempting pregnancy in the postoperative period and five (25%) of them had achieved natural pregnancy. CONCLUSIONS: Men with TMSC 2 million was most predictive of semen quality upgrading.
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Introduction

We aimed to determine the time and predictive factors of semen quality improvement in men with severe oligospermia after microsurgical varicocelectomy.

Methods

Men with total motile sperm count (TMSC) 6 months. We evaluated preoperative factors for successful semen quality upgrading based on assisted reproductive technology (ART) eligibility: in vitro fertilization [IVF] (9 million). We compared men with TMSC 6 months postoperatively.

Results

A total of 33 men were included. TMSC improved from 1.5±0.2 to 7.3±1.8 million at 3–6 months (p6 months (p6 months. Sixteen (48.5%) men upgraded semen quality into the range of natural pregnancy. Preoperative TMSC from 2–5 million was predictive of upgrading semen quality. Twenty-four couples were contacted by phone; 20 were attempting pregnancy in the postoperative period and five (25%) of them had achieved natural pregnancy.

Conclusions

Men with TMSC 2 million was most predictive of semen quality upgrading. Downloads Downloads Published How to Cite Issue Section License You, the Author(s), assign your copyright in and to the Article to the Canadian Urological Association. This means that you may not, without the prior written permission of the CUA: - Post the Article on any Web site - Translate or authorize a translation of the Article - Copy or otherwise reproduce the Article, in any format, beyond what is permitted under Canadian copyright law, or authorize others to do so - Copy or otherwise reproduce portions of the Article, including tables and figures, beyond what is permitted under Canadian copyright law, or authorize others to do so. The CUA encourages use for non-commercial educational purposes and will not unreasonably deny any such permission request. You retain your moral rights in and to the Article. This means that the CUA may not assert its copyright in such a way that would negatively reflect on your reputation or your right to be associated with the Article. The CUA also requires you to warrant the following: - That you are the Author(s) and sole owner(s), that the Article is original and unpublished and that you have not previously assigned copyright or granted a licence to any other third party; - That all individuals who have made a substantive contribution to the article are acknowledged; - That the Article does not infringe any proprietary right of any third party and that you have received the permissions necessary to include the work of others in the Article; and - That the Article does not libel or violate the privacy rights of any third party.

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