Urogynecological Outcomes After Minimally Invasive Surgery for Deep Endometriosis: A Systematic Review

Endometriosis is a chronic, estrogen-dependent inflammatory disease affecting approximately 6–10% of women of reproductive age and up to 50% of those with infertility or chronic pelvic pain. 1 One of its most severe manifestations is deep endometriosis (DE), defined as lesions penetrating more than 5 mm beneath the peritoneal surface. 2 The pathophysiology of DE involves complex interactions among ectopic endometrial implants, neuroangiogenesis, inflammation, and fibrosis, ultimately leading not only to pelvic pain and infertility but also to functional impairment of affected pelvic organs. 3 DE accounts for 15–30% of all endometriosis cases and commonly involves the uterosacral ligaments, rectovaginal septum, bladder, bowel, and ureters. 4 Urinary tract involvement in DE has been reported in 0.3–12% of cases, most frequently affecting the bladder (up to 85%) and, less commonly, the ureters. 5 Patients with bladder endometriosis often experience lower urinary tract symptoms (LUTS) such as urgency, frequency, dysuria, suprapubic pain, and occasionally hematuria—symptoms that frequently correlate with the menstrual cycle. 5 Ureteral endometriosis, though often asymptomatic, poses a serious risk of silent ureteral obstruction, hydronephrosis, and subsequent renal function loss. 6 Surgical excision remains the cornerstone of treatment for symptomatic DE, particularly when the urinary tract is involved—most notably the ureters, where obstruction and hydronephrosis may lead to silent and progressive renal impairment. 7 Minimally invasive approaches such as laparoscopic excision have become standard, with nerve-sparing techniques increasingly employed to minimize postoperative complications. 3 , 7 In cases of bladder endometriosis, partial cystectomy or bladder shaving may be performed, with symptomatic improvement reported in over 90% of patients. 8 However, such procedures are not without risk: detrusor hypoactivity, urinary retention, and voiding dysfunction occur in up to 18% of cases, particularly in the absence of nerve-sparing strategies. 9 In addition, surgical management of ureteral endometriosis may require ureterolysis or segmental ureteral resection with ureteroneocystostomy when obstruction is present. 10 Despite technical advances, the impact of DE surgery on urinary function remains controversial. Several prospective studies have reported improvements in LUTS and urodynamic parameters following nerve-sparing laparoscopic resection with significant reductions in urgency and dysuria. 9 Conversely, other studies have shown unchanged or even worsened urinary function postoperatively, particularly among patients with mild preoperative dysfunction. 11 In general, these inconsistencies may be attributed to multiple factors, including heterogeneity in study design, small sample sizes, variability in surgical techniques (extent of resection, nerve-sparing versus non-nerve-sparing), and differences in outcome measures. While some studies include urodynamic testing, others rely exclusively on symptom-based questionnaires, which vary in both scope and sensitivity. 12 , 13 Moreover, the lack of standardization in the timing of postoperative assessments—ranging from a few weeks to over a year—further complicates interpretation. Moreover, it is difficult to distinguish whether postoperative symptoms reflect the impact of the disease itself or a surgery-related functional impairment. Furthermore, only few studies have adopted objective evaluation methods such as urodynamics. To date, few systematic reviews have specifically addressed urogynecological outcomes following DE surgery. Most reviews have focused more broadly on pain, fertility, or gastrointestinal function. 6 , 12 , 13 Given the significant burden urinary symptoms place on quality of life and the risk of iatrogenic dysfunction, a targeted synthesis of the evidence is both timely and necessary. This review therefore aims to systematically evaluate the impact of minimally invasive surgical treatment for DE on urinary symptoms, comparing pre- and postoperative outcomes using validated assessment tools. By examining studies with rigorous methodology and standardized outcome measures, we aim to clarify whether surgery provides functional benefits or poses risks to urinary health in women with DE. This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement. 14 No institutional review board approval was required as only previously published, de-identified data were analyzed. All authors contributed to the development of the search strategy and to the definition of inclusion and exclusion criteria. The protocol was registered on PROSPERO (ID: CRD420251113885). A systematic computerized literature search was carried out in three electronic databases—PubMed, Scopus, and the Cochrane Library—from database inception to June 2025. The search strategy included a combination of MeSH terms and free-text keywords as follows: (“endometriosis” OR “pelvic endometriosis”) AND (“surgery” OR “surgical treatment” OR “laparoscopic surgery”) AND (“urogynecological disorders” OR “urinary incontinence” OR “bladder dysfunction” OR “urinary symptoms”) AND (“postoperative” OR “after surgery”). Reference lists of all included studies and relevant reviews were also manually screened to identify additional potentially eligible articles. All retrieved articles were reviewed by the authors. The reviewers were not blinded to the names of the authors or the sources of publication. Discrepancies were resolved by discussion and consensus. Eligibility was first assessed based on titles and abstracts; full-text versions of potentially relevant studies were then obtained and examined to determine final inclusion. This review included peer-reviewed journal articles published in English, Italian, or French within the last 25 years. Eligible studies focused on women diagnosed with DE who underwent laparoscopic or robotic surgical excision. To be included, studies had to evaluate postoperative urinary or urogynecological function. Accepted study designs included randomized controlled trials (RCTs), prospective and retrospective cohort studies, and case-control studies involving at least five patients. Studies were excluded if they were animal or in vitro experiments, focused on non-endometriosis gynecologic conditions, or employed open surgical approaches. Articles were also excluded if they did not report postoperative urinary outcomes or did not use validated assessment tools. All studies retrieved from the search were independently screened by two reviewers. Any disagreement regarding inclusion was resolved through discussion or with the involvement of a third reviewer. Given the wide heterogeneity in study populations, surgical techniques, outcome measures, and follow-up duration, a quantitative synthesis (meta-analysis) was not feasible. Instead, a descriptive synthesis was performed. The quality of observational studies was assessed using the Newcastle–Ottawa Scale (NOS), evaluating selection, comparability, and outcome domains. Assessments were conducted independently by two reviewers. Details of bias assessment are available in Table 1 . Table 1 Assessment of Included Studies Using the Newcastle–Ottawa Scale (NOS) Study Representative of the Exposed Cohort Selection of External Control Ascertainment of Exposure Outcome of Interest Not Present at the Start Comparability of Cohorts (Main Factor) Comparability of Cohorts (Additional Factor) Assessment of Outcomes Sufficient Follow-Up Time Adequacy of Follow-Up Total score Carvalho et al (2023) 15 * 0 * * * * * * * 9/9 Nguyen et al (2024) 16 * 0 * * * 0 * * * 8/9 Garavaglia et al (2018) 17 * 0 * * * 0 * 0 * 6/9 Seracchioli et al (2010) 6 * 0 * * * 0 * * * 8/9 Laterza et al (2022) 13 * 0 * * * * * * * 9/9 Riiskjaer et al (2016) 18 * 0 * * * * * 0 * 7/9 Roman et al (2021) 19 * 0 * * * 0 * * * 8/9 Massimello et al (2024) 20 * 0 * * * * * * * 9/9 Dior et al (2022) 21 * 0 * * * * * * * 9/9 Notes : Symbols: “*” = criterion satisfied; “0” = criterion not satisfied/unclear. Total score (maximum = 9) reflects study quality. Assessment of Included Studies Using the Newcastle–Ottawa Scale (NOS) Notes : Symbols: “*” = criterion satisfied; “0” = criterion not satisfied/unclear. Total score (maximum = 9) reflects study quality. Due to the diversity in methodologies and outcome reporting, the results were synthesized narratively. Trends in urinary function—whether improvement, worsening, or no change—were extracted and summarized based on validated symptom questionnaires, such as International Consultation on Incontinence Questionnaire (ICIQ), Urinary Symptom Profile (USP), International Prostate Symptom Score (IPSS) and, where available, objective urodynamic evaluations.

A total of 175 studies were identified through database searches (PubMed = 50, Scopus = 116, Cochrane Library = 9). After removal of 54 duplicates, 121 studies were screened by title and abstract. 83 records were excluded based on automatic criteria. Full-text screening was performed on 38 articles, of which 9 met the inclusion criteria. The PRISMA flowchart in Figure 1 summarizes the selection process. 22 Figure 1 PRISMA 2020 flow diagram for new systematic reviews which included searches of databases and registers only. PRISMA 2020 flow diagram for new systematic reviews which included searches of databases and registers only. The nine studies included encompassed a sample size range from 20 to 289 participants. All studies involved women diagnosed with DE undergoing minimally invasive surgery (laparoscopic or robotic). Various validated tools were used to assess urinary symptoms pre- and post-operatively, including ICIQ-Urinary Incontinence Short Form (ICIQ-UI SF), 23 ICIQ-Overactive Bladder module (ICIQ-OAB), 24 ICIQ-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS), 25 ICIQ-Lower Urinary Tract Symptoms Quality of Life (ICIQ-LUTSqol), 26 USP, 27 IPSS, 28 and formal urodynamic testing. The follow-up period ranged from 6 weeks to 12 months. Study characteristics are presented in Table 2 . Table 2 Characteristics and Main Findings of Studies Evaluating Urinary Outcomes After Minimally Invasive Surgery for Deep Endometriosis Study (First Author, Year) Study Type Sample Size Questionnaires/Tools Used Main Findings Conclusions Seracchioli et al, 2010 6 Prospective observational study 56 VAS scale (dysuria and suprapubic pain), presence or absence (frequency, urgency, and hematuria) Significant postoperatively improvement in the mean score of dysuria (mean VAS score of 1 ±1.56, 95% CI 0.51–1.49; p < 0.05), in the mean suprapubic pain score (p < 0.05). At the end of follow-up, symptoms disappeared in 11 out of 20 patients with frequency symptoms, in 7 out of 14 with urgency symptoms, and in 1 out of 3 with hematuria. Conservative laparoscopic surgical treatment for urinary tract endometriosis provides long-term relief of urinary symptoms. Laterza et al, 2022 13 Prospective observational study 32 ICIQ-UI SF, ICIQ-OAB, Urodynamics Significant postoperatively improvement of all cystomanometric parameters (first desire to void p < 0.001 and the bladder capacity p = 0.011), voiding flow (p = 0.026) and ICIQ-SF (p = 0.0005) and ICIQ-OAB (p <0.001) questionnaires In a selected population of patients with deep endometriosis (not requiring bowel or ureteral resection), the bladder function improves after surgery Riiskjaer et al, 2016 18 Prospective observational study 128 ICIQ, SVQ, Uroflowmetry Significant postoperatively improvement in bladder filling problems (p = 0.002), in bladder pain (p = 0.0001), in overall sexual satisfaction (p = 0.0001). No change for urodynamic parameters was observed. Frequency of defecation was significantly increased (p = 0.0001), but the overall bowel function measured by LARS score was unchanged. A significant and clinically relevant improvement in urinary and sexual function after laparoscopic bowel resection for endometriosis was found Garavaglia et al, 2018 17 Prospective observational study 20 VAS scale 100-point rank No differences in terms of urinary symptoms: dysuria (p = 0.70), urinary pain (p = 0.72), hematuria (p = 0.31), urgency (p = 1.0) and urinary incontinence (p = 1.0) were found between the two time periods - preintervention and 12 months postoperatively No differences in terms of urinary symptoms Dior et al, 2022 21 Prospective observational cohort study 149 ICIQ-FLUTS Significant postoperatively improvement of the filling score at 6 weeks, 6 months and 12 months (p <0.001, p =0.009, and p = 0.02 respectively), the incontinence score at 6 weeks (p <0.001) but not hereafter. No change in bladder voiding score. Patients with low preoperative summary scores had higher summary scores (worse function) after surgery, and patients with high preoperative scores had lower summary scores (improved function) after surgery Roman et al, 2021 19 Retrospective case series 52 USP A non-statistically significant worsening of the postoperatively USP (p = 0.08) Tendency toward an overall impairment of bladder function (non-statistically significant) Carvalho et al, 2023 15 Prospective observational study 44 IPSS A statistically significant difference was found comparing the changes from absent/mild to moderate/severe IPSS categories (P = 0.039). No significant changes were identified in any of the IPSS (p = 0.876) No significant change was observed in total IPSS scores postoperatively, but a significant worsening occurred in patients shifting from absent/mild to moderate/severe symptoms Massimello et al, 2024 20 Retrospective comparative study 88 USP Impaired urinary function after surgery in the laparoscopic group (mean 1.64 ± 1.78 vs 2.64 ± 2.29 P = 0.028) and in the robotic-assisted group (mean 1.67 ± 1 vs 3.89 ± 3.41, P = 0.031). Impaired urinary function after surgery Nguyen et al, 2024 16 Nested cohort study within a larger RCT 289 ICIQ-FLUTS, ICIQ-LUTSqol Worsening of symptoms for filling, voiding, incontinence (ICIQ-FLUTS), and quality of life (ICIQ-LUTSqol) pre-operative to post-operatively (2.27 vs 3.32, 0.93 vs 2.02, 1.06 vs 2.32, 0.83 vs 2.13 respectively, p < 0.001). Decline in urinary function over time following laparoscopic surgery for endometriosis that is not dependent on the severity or location of the disease. Abbreviations : VAS, Visual Analogue Scale; ICIQ, International Consultation on Incontinence Questionnaire; ICIQ-UI SF, International Consultation on Incontinence Questionnaire – Urinary Incontinence Short Form; ICIQ-OAB, International Consultation on Incontinence Questionnaire – Overactive Bladder module; ICIQ-FLUTS, International Consultation on Incontinence Questionnaire – Female Lower Urinary Tract Symptoms; ICIQ-LUTSqol, International Consultation on Incontinence Questionnaire – Lower Urinary Tract Symptoms Quality of Life; SVQ, Sexual Vaginal Questionnaire; USP, Urinary Symptom Profile; IPSS, International Prostate Symptom Score; Urodynamics, urodynamic testing; LARS, Low Anterior Resection Syndrome score; Characteristics and Main Findings of Studies Evaluating Urinary Outcomes After Minimally Invasive Surgery for Deep Endometriosis Abbreviations : VAS, Visual Analogue Scale; ICIQ, International Consultation on Incontinence Questionnaire; ICIQ-UI SF, International Consultation on Incontinence Questionnaire – Urinary Incontinence Short Form; ICIQ-OAB, International Consultation on Incontinence Questionnaire – Overactive Bladder module; ICIQ-FLUTS, International Consultation on Incontinence Questionnaire – Female Lower Urinary Tract Symptoms; ICIQ-LUTSqol, International Consultation on Incontinence Questionnaire – Lower Urinary Tract Symptoms Quality of Life; SVQ, Sexual Vaginal Questionnaire; USP, Urinary Symptom Profile; IPSS, International Prostate Symptom Score; Urodynamics, urodynamic testing; LARS, Low Anterior Resection Syndrome score; Among the studies reporting improvements in urinary function, several consistent trends emerged. The earliest of these, published by Seracchioli et al in 2010, analyzed a cohort of 74 women with laparoscopically and histologically confirmed urinary tract endometriosis, predominantly involving the bladder but also the ureters. At baseline, cyclical LUTS such as dysuria, suprapubic pain, urgency, frequency, and hematuria were common. Following conservative laparoscopic treatment, there was a significant reduction in dysuria and suprapubic pain, with mean Visual Analogue Scale (VAS) score for dysuria decreasing to 1.0 ± 1.56 (95% CI 0.51–1.49; p < 0.05). At the end of follow-up, symptoms resolved in over half of the patients presenting with urinary frequency or urgency. 6 Similarly, Riiskjaer et al included 128 women undergoing laparoscopic bowel resection for rectosigmoid DE at a tertiary referral center. Baseline evaluations demonstrated frequent bladder filling problems and pain, in addition to intestinal dysfunction and impaired sexual function. One year after surgery, significant improvements were noted in bladder filling problems (p = 0.002) and bladder pain (p = 0.0001), accompanied by increased sexual satisfaction (p = 0.0001). However, no changes were observed in urodynamic parameters. 18 In the prospective multicenter study by Laterza et al, 32 women with DE—excluding those requiring bowel or ureteral resection—were evaluated with ICIQ-UI SF, ICIQ-OAB, and urodynamic testing. At baseline, urgency and reduced bladder capacity were frequent findings. Postoperatively, patients experienced significant improvements in both subjective and objective parameters: first desire to void increased from 120 to 204 mL (p < 0.001), bladder capacity from 358 to 409 mL (p = 0.011), and maximal voiding flow from 19 to 25 mL/s (p = 0.026). Questionnaires also improved markedly, with ICIQ-UI SF decreasing from 2.5 to 0 (p = 0.0005) and ICIQ-OAB from 4.3 to 1.2 (p < 0.001). 13 Consistent results were reported by Dior et al in a larger prospective cohort of 149 women with DE. Using the ICIQ-FLUTS questionnaire, the authors observed significant improvements in filling scores at 6 weeks (p < 0.001), 6 months (p = 0.009), and 12 months (p = 0.02). Incontinence scores improved at 6 weeks (p < 0.001) but not thereafter, while voiding scores remained unchanged. Notably, benefits were more pronounced among women with severe baseline symptoms, whereas those with minimal preoperative dysfunction occasionally experienced postoperative worsening. 21 In contrast, several studies reported no significant change or a deterioration in urinary function. In 2018, Garavaglia et al evaluated 20 women with stage IV (according to the American Society of Reproductive Medicine) intestinal DE involving the rectosigmoid or rectum. Despite severe gynecological and gastrointestinal symptoms at baseline, no postoperative improvements in urinary function were observed: dysuria (p = 0.70), urinary pain (p = 0.72), hematuria (p = 0.31), urgency (p = 1.0), and incontinence (p = 1.0). 17 In 2021 Roman et al investigated 52 women with DE involving the sacral roots and sciatic nerve, most of whom presented with sciatic pain (82.7%), pudendal neuralgia (21.2%), motor weakness (27%), and associated bladder dysfunction. At one year, there was a non-significant tendency toward worsening urinary symptoms (p = 0.08). 19 One year later, Carvalho et al assessed 44 women with rectosigmoid DE treated with nerve-sparing laparoscopic resection. The median age was 39 years, and more than half were overweight (median BMI 25.8 kg/m 2 ). At baseline, LUTS were frequent, with over 50% classified as moderate-to-severe by IPSS. Postoperatively, no significant change was observed in total IPSS scores (p = 0.876), but a significant worsening occurred in patients shifting from absent/mild to moderate/severe categories (p = 0.039). 15 Similarly, in 2024 Massimello et al compared 71 women treated with conventional laparoscopy and 29 treated with robotic-assisted laparoscopy for DE involving the sacral plexus and sciatic nerve. Baseline characteristics were comparable, with frequent bladder, rectal, and sexual dysfunction. Both groups experienced worsening postoperative urinary function: USP increased from 1.64 ± 1.78 to 2.64 ± 2.29 (p = 0.028) in the laparoscopic group and from 1.67 ± 1.00 to 3.89 ± 3.41 (p = 0.031) in the robotic group. 20 Finally, in the largest study included Nguyen et al (same year), followed 289 women with histologically confirmed DE nested within a randomized trial. The mean age was 32.7 years, 72% were nulliparous, and the mean BMI was 25.8 kg/m 2 . Disease was frequently extensive, with uterosacral, rectovaginal, and pararectal involvement. At a mean follow-up of 50 months, a consistent and statistically significant deterioration was observed across all ICIQ-FLUTS domains: filling (from 2.27 to 3.32), voiding (from 0.93 to 2.02), incontinence (from 1.06 to 2.32), and LUTS-related quality of life (from 0.83 to 2.13), all p < 0.001. 16

In summary, minimally invasive surgery for DE has the potential to achieve meaningful improvements in lower urinary tract symptoms, particularly in patients with pronounced preoperative dysfunction. However, a clinically relevant subset of patients may experience deterioration in bladder function postoperatively, especially in the absence of nerve-sparing techniques or in those with minimal baseline symptoms. The considerable heterogeneity in patient characteristics, outcome measures, and statistical methodologies across current studies underscores the urgent need for more rigorous, standardized research to inform evidence-based patient selection and surgical planning.

This systematic review evaluated the impact of minimally invasive surgery for DE on urogynecological symptoms, analyzing data from nine studies with sample sizes ranging from 20 to 289 patients. The findings reveal substantial heterogeneity in outcomes, reflecting both clinical diversity and methodological variability across studies. A major source of heterogeneity was the variability in outcome measures. While some studies focused on specific urinary symptoms—such as dysuria, urgency, and frequency—others incorporated urodynamic parameters or patient-reported quality-of-life indices as primary endpoints. For example, Dior et al employed the ICIQ-FLUTS and ICIQ-LUTSqol to capture longitudinal changes, whereas Laterza et al combined subjective questionnaires with objective urodynamic measures, providing a more comprehensive assessment of bladder function. 13 , 21 When looking at the symptom domains, a clear pattern emerges. Storage symptoms (urgency, frequency, dysuria) are those most consistently improved after surgery, particularly in patients with moderate-to-severe baseline dysfunction. Seracchioli et al documented a marked reduction in dysuria and suprapubic pain, with resolution of frequency and urgency in over half of symptomatic patients. 6 Laterza et al showed significant improvements in first desire to void, bladder capacity, and uroflowmetry in addition to questionnaire scores, 13 while Dior et al reported improvements in filling symptoms at 6 weeks, 6 months and 12 months. 21 These findings suggest that surgery, especially when nerve-sparing techniques are adopted, can relieve storage complaints linked to compression of pelvic structures and local inflammation. By contrast, voiding-related symptoms and global bladder function appear less responsive. Several studies noted no significant change in urodynamic parameters despite improvements in self-reported symptoms. 6 , 21 Moreover, Roman et al described a non-significant worsening of USP scores after surgery for sacral nerve involvement, 19 Carvalho et al found a significant shift toward more severe categories on the IPSS despite stable overall scores 15 and Massimello et al reported worsening USP scores in both laparoscopic and robotic-assisted groups. 20 The largest cohort by Nguyen et al highlighted consistent deterioration across all ICIQ-FLUTS domains and quality-of-life measures at long-term follow-up. 16 Taken together, these results suggest that voiding function, detrusor contractility, and long-term bladder adaptation remain the most vulnerable aspects, particularly in patients with minimal baseline symptoms where postoperative deterioration was more common. Considerable inconsistency was also observed in the measurement tools employed. A variety of validated instruments were used, including ICIQ-UI SF, 23 ICIQ-OAB, 24 ICIQ-FLUTS, 25 ICIQ-LUTSqol, 26 USP, 27 and IPSS 28 - each differing in domain focus and sensitivity. Notably, the IPSS, originally designed for male voiding symptoms, may have limited sensitivity in women. This heterogeneity in scoring systems precludes direct cross-study comparisons and contributes to the inconsistency in reported outcomes, a limitation previously noted in systematic reviews addressing urinary function in endometriosis. Pre- versus postoperative comparisons were conducted using non-uniform criteria. Some studies assessed changes at multiple time points (eg, Dior et al), while others reported outcomes at a single interval. 21 The duration of follow-up ranged from 6 weeks to over 4 years, potentially obscuring late-onset deterioration or delayed recovery. Short-term symptom relief may therefore not fully capture long-term outcomes, given that bladder adaptation and autonomic neuroregeneration can extend over months or years. Differences in study populations further complicated interpretation. Laterza et al limited inclusion to patients without bowel or ureteral involvement, whereas Riiskjaer et al included women undergoing bowel resection. 13 , 18 These anatomical differences likely influenced the risk of autonomic nerve injury and the trajectory of postoperative bladder function. Similarly, the extent of parametrial or sacral nerve involvement, as in Roman and Massimello’s series, correlates with higher risk of postoperative dysfunction. 19 , 20 Surgical technique was another important variable. Although all studies employed minimally invasive approaches, only some explicitly reported nerve-sparing procedures. The implementation of nerve-sparing dissection is known to reduce detrusor hypoactivity and urinary retention. Nevertheless, even with advanced techniques, deterioration was reported in some series, suggesting that the complexity of nerve involvement and extent of resection may outweigh technical refinements. A particularly influential factor was the preoperative symptom profile. Dior et al noted that patients with more severe baseline LUTS derived the greatest benefit from surgery, while those with minimal symptoms were more likely to deteriorate. 21 This ceiling effect has been observed in other domains of endometriosis surgery and underlines the need for careful patient selection and counseling. Despite the heterogeneity, some consistent messages can be drawn: storage symptoms (urgency, frequency, dysuria) are more likely to improve, whereas voiding dysfunction and global bladder performance often remain unchanged or worsen. A key strength of this review lies in the exclusive inclusion of studies utilizing validated instruments for the assessment of urinary function. This methodological rigor minimizes the risk of bias associated with anecdotal or non-standardized outcome reporting. Furthermore, the focus on minimally invasive surgical approaches enhances the clinical applicability of the findings, aligning with current standards of care in endometriosis management. Nevertheless, several limitations must be acknowledged. The substantial heterogeneity among the included studies—particularly in terms of outcome definitions, measurement tools, surgical techniques, and follow-up intervals—introduced significant variability that precluded the conduct of a quantitative meta-analysis. The absence of standardized time points and symptom classifications across studies limits the external validity and comparability of the results. Additionally, the potential for publication bias cannot be excluded, as studies reporting neutral or negative findings are less likely to be published and included in systematic reviews. Well-designed randomized controlled trials are needed to compare nerve-sparing versus non–nerve-sparing surgical techniques, with predefined and harmonized follow-up assessments (eg, at 3, 6, and 12 months). Importantly, future studies should incorporate both subjective outcomes—such as those captured by validated questionnaires (eg, ICIQ, USP)—and objective functional assessments, including urodynamic testing and uroflowmetry, to provide a comprehensive evaluation of postoperative urinary function.