Periosteal distraction technology for stroke recovery: A game changer for neurorehabilitation?

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Patients often face cognitive, sensory, and motor deficits, with incomplete spontaneous recovery. Early intervention is crucial, as significant motor improvements happen within three months, while cognitive enhancements may take months to years. Recently, the periosteal traction (PD) technique has gained traction in treating chronic lower limb ischemia, with speculation that it effectively promotes angiogenesis and tissue regeneration. This paper presents three cases of stroke patients managed with PD technology in the late chronic stage, showing significant functional improvements. PD treatment may restore brain function by enhancing neuroplasticity and improving blood flow in ischemic areas. Although results are promising, limitations include a small sample size and short follow-up, with further research needed to optimize treatment protocols and understand underlying mechanisms. In conclusion, PD shows good potential for functional recovery in stroke patients, warranting further basic and clinical studies to bolster its application." } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/14-426/v1", "name": "Periosteal distraction technology for stroke recovery: A game changer..." } } ] } Home Browse Periosteal distraction technology for stroke recovery: A game changer... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article You MD Y, Huang MD J, Zhou MD X et al. Periosteal distraction technology for stroke recovery: A game changer for neurorehabilitation? [version 1; peer review: awaiting peer review] . F1000Research 2025, 14 :426 ( https://doi.org/10.12688/f1000research.162479.1 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Clinical Practice Article Periosteal distraction technology for stroke recovery: A game changer for neurorehabilitation? [version 1; peer review: awaiting peer review] Yi You MD 1 , Jundong Huang MD https://orcid.org/0000-0003-3799-6262 2 , Xiangkai Zhou MD 3 , [...] Yan Ma MD 4 , Mingqi Yi MD 5 , Huiyan Liu MD 1 , Jing Luo MD 6 , Fang Wei MD 3 , Wei Shi MD,PhD 2 , Naxin Zeng MD 1,3 Yi You MD 1 , Jundong Huang MD https://orcid.org/0000-0003-3799-6262 2 , [...] Xiangkai Zhou MD 3 , Yan Ma MD 4 , Mingqi Yi MD 5 , Huiyan Liu MD 1 , Jing Luo MD 6 , Fang Wei MD 3 , Wei Shi MD,PhD 2 , Naxin Zeng MD 1,3 PUBLISHED 11 Apr 2025 Author details Author details 1 Department of Cardiac and Vascular Surgery, Yueyang Central Hospital, No.39 Yuedong Road, Yueyang, China, Yueyang, China 2 Department of Dermatology, Xiangya Hospital, Central South University, Hu Nan Key Laboratory of Aging Biology, Changsha, China, changsha, China 3 Department of Surgery, Yueyang Renya Rehabilitation Hospital, No.68 Rong Road, Yueyang county, China, Yueyang, China 4 Department of Neurology, Yueyang Central Hospital, No.39 Yuedong Road, Yueyang, China, Yueyang, China 5 Department of Neurosurgery, Yueyang Central Hospital, No.39 Yuedong Road, Yueyang, China, Yueyang, China 6 Department of Rehabilitation Medicine, Yueyang Central Hospital, No.39 Yuedong Road, Yueyang, China, Yueyang, China Yi You MD Roles: Data Curation, Writing – Original Draft Preparation Jundong Huang MD Roles: Writing – Original Draft Preparation Xiangkai Zhou MD Roles: Data Curation Yan Ma MD Roles: Data Curation Mingqi Yi MD Roles: Data Curation Huiyan Liu MD Roles: Data Curation Jing Luo MD Roles: Data Curation Fang Wei MD Roles: Data Curation Wei Shi MD,PhD Roles: Supervision, Validation Naxin Zeng MD Roles: Data Curation, Supervision, Validation OPEN PEER REVIEW REVIEWER STATUS AWAITING PEER REVIEW Abstract Stroke disrupts brain structure, leading to long-term disabilities despite improved survival rates. Patients often face cognitive, sensory, and motor deficits, with incomplete spontaneous recovery. Early intervention is crucial, as significant motor improvements happen within three months, while cognitive enhancements may take months to years. Recently, the periosteal traction (PD) technique has gained traction in treating chronic lower limb ischemia, with speculation that it effectively promotes angiogenesis and tissue regeneration. This paper presents three cases of stroke patients managed with PD technology in the late chronic stage, showing significant functional improvements. PD treatment may restore brain function by enhancing neuroplasticity and improving blood flow in ischemic areas. Although results are promising, limitations include a small sample size and short follow-up, with further research needed to optimize treatment protocols and understand underlying mechanisms. In conclusion, PD shows good potential for functional recovery in stroke patients, warranting further basic and clinical studies to bolster its application. READ ALL READ LESS Keywords Periosteal distraction; stroke; neurorehabilitation; case report Corresponding Author(s) Wei Shi MD,PhD ( [email protected] ) Naxin Zeng MD ( [email protected] ) Close Corresponding authors: Wei Shi MD,PhD, Naxin Zeng MD Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2025 You MD Y et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: You MD Y, Huang MD J, Zhou MD X et al. Periosteal distraction technology for stroke recovery: A game changer for neurorehabilitation? [version 1; peer review: awaiting peer review] . F1000Research 2025, 14 :426 ( https://doi.org/10.12688/f1000research.162479.1 ) First published: 11 Apr 2025, 14 :426 ( https://doi.org/10.12688/f1000research.162479.1 ) Latest published: 11 Apr 2025, 14 :426 ( https://doi.org/10.12688/f1000research.162479.1 ) Introduction Stroke alters the brain's structure, affecting various systems. Despite improved survival rates, it remains a leading cause of long-term disability worldwide. 1 Post-stroke deficits include cognitive, sensory, visual, and language impairments, with motor impairments being the most common. 2 Most patients experience some spontaneous recovery, defined as time-dependent improvement in body function and activity. 3 However, this recovery is often incomplete, and neurological recovery rates vary. Motor impairments are the most frequently diagnosed and studied, with significant gains occurring within the first 3 months. 3 Recovery of visuospatial neglect and orientation typically occurs 5-6 months post-stroke, while improvements in cognition, memory, and language can extend over months to years. 3 The optimal restorative strategy is controversial. 4 For patients who miss the optimal treatment window, conservative treatment approaches are frequently insufficient, underscoring the critical importance of early and aggressive intervention. 4 Periosteal traction (PD) technique has recently been widely used to treat chronic lower limb-threatening ischemia, including diabetic foot 5 and arteriosclerosis obliterans. 6 It is speculated that PD surgery can effectively promote angiogenesis and tissue regeneration. In clinical practice, we also found that PD postoperative angiography showed significant new blood vessels on the surgical side. Therefore, a reasonable and highly attractive hypothesis is that applying PD technology for stroke while balancing safety and convenience, which would benefit the patient as well as lowering the budget impact. Here we present 3 cases of post-stroke patients that were managed with PD technology in the late chronic stage. Methods Study design and patients This retrospective study included post-stroke patients who were more than six months post-injury and received PD surgery between June 2024 and February 2025. The diagnosis of stroke was established based on clinical presentations and imaging findings. To thoroughly assess the potential therapeutic effects of PD, we specifically selected patients whose neurological recovery had reached a plateau. We excluded individuals lacking detailed information about the nature of their stroke and those with a history of potential additional brain injuries, such as traumatic brain injury, anoxic brain injury, or subarachnoid hemorrhage. This study received approval from our Institutional Review Board, and written informed consent was obtained from all participants. PD surgery The surgical site was located contralateral to the hemiplegic limb. The center of the marked point was positioned 2 cm below the junction of the ear canal and the parietal tubercle. A 3-cm longitudinal scalp incision was made parallel to the parietal tubercle. A vertical incision was then performed through the temporal region and the periosteum, extending approximately 1 cm to the skull. A subperiosteal channel measuring 3 cm in length and 1 cm in width was created in the skull. Two microfractures were drilled into the outer table of the skull, and a periosteal stretch system (Kehui's periosteal stretch system) was inserted into the subperiosteal channel. The stretch screw was advanced into the skull using a screw fixation needle until it reached the inner table. A second screw fixation needle was then inserted parallel to secure the periosteum and the cap-like fascia of the temporal muscle. Refer to Figure 1 for a schematic representation of the surgical procedure. Figure 1. Surgical procedure chart. a-c: After the skin incision, the peroneal aponeurosis and the cranial membrane were transected, exposing the parietal bone; d-f: subperiosteal implantation of the plate. Drill a Φ1.5mm Kirschner wire in the distal hole of distraction plate. Insert a special locking hollow screw along the Kirschner wire and lock it to distal hole, leaving part of the screw exposed outside the skin for periodic postoperative adjustments. Drill another K-wire to a depth of 5 mm into the single-layer cortex in the most-distal hole of distraction plate to prevent lateral rotation of the plate; g-i: skin sutures were performed. Intraoperative X-rays confirmed the accurate placement of the instrument. Postoperative management Considering the compliance of the periosteum of the skull, we then stretched the plate at a rate of 0.5 mm per day (0.25 mm in the morning, and 0.25 mm in the evening). After 3 weeks of stretching, the distraction plates, and screws were removed. During the distraction period, attention was paid to nursing the wound at the distractor, to prevent complications such as nail tract infection and periosteal infection, and we kept the nail tract and surrounding skin tissue under close observation. Case presentation Patient 1 was a 62-year-old male with a history of hypertension and diabetes, diagnosed with a left hemisphere ischemic stroke two years prior. He was receiving long-term treatment with clopidogrel, rosuvastatin, amlodipine, metformin, and inglitazone. Preoperative evaluation revealed right limb dysfunction (right shoulder abduction at 60 degrees, muscle strength graded at 3, and hypertonia), central facial palsy, and speech dysfunction. On the second postoperative day, these symptoms showed significant improvement, with the most notable recovery in facial nerve function and speech. By the 18th postoperative day, right shoulder abduction had improved to 80 degrees, with muscle strength rated at 5. However, a follow-up three months after surgery indicated a deterioration in the patient's symptoms compared to postoperative status, suggesting that PD surgery may need to be performed regularly to maintain efficacy. Patient 2 is a 68-year-old male diagnosed with a left basal ganglia cerebral infarction six years ago. After undergoing routine rehabilitation training, he achieved partial recovery of function in the affected area. Preoperative evaluation indicated right-sided hemiplegia, characterized by limited shoulder abduction (approximately 70 degrees) and elbow extensor muscle strength rated at grade 3. Wrist extensor muscle strength was also graded at 3, and the patient was unable to extend the right thumb. Additionally, muscle strength in the quadriceps, tibialis anterior, and both long and short fibular muscles was rated at grade 3. By the 20th postoperative day, significant recovery of motor function was observed, including improved shoulder and elbow joint function, partial recovery of thumb extension, and an increase in finger extensor muscle strength to grade 4. Lower limb muscle strength reached grade 5, enabling the patient to ambulate slowly without noticeable gait abnormalities. Patient 3 is a 54-year-old male with a history of cerebral infarction lasting over ten years, initially managed with long-term oral nifedipine for blood pressure control. Preoperative evaluation revealed reduced muscle strength in the right limbs, with a strength grade of 3 in the right upper limb and 4 in the right lower limb. The patient exhibited limited movement in the four fingers of his right hand (excluding the thumb), which impaired his ability to form a fist. After 14 days of follow-up, significant improvement in the finger function of his right hand was noted compared to its initial state. However, the patient is currently lost to follow-up. To objectively evaluate the impact of PD surgery on cerebral blood perfusion, Patient 3 underwent Computed tomography Perfusion imaging (CTP) of the head both before the surgical procedure and 60 days postoperatively. The CTP results demonstrated that the PD surgery effectively enhanced cerebral blood supply in the patient ( Figure 2 ). Figure 2. Results of Computed tomography Perfusion imaging (CTP) before and after PD surgery. A-B: Preoperative cranial CTP showed decreased MTT and TTP , and decreased CBV and CBF in the left basal ganglia region; C-D: Postoperative cranial CTP showed MTT and TTP were shorter, and CBV and CBF were increased compared with the preoperative period in the left basal ganglia region; MTT: mean transit time, TTP: time to peak, CBV: cerebral blood volume, CBF: cerebral blood flow. Discussion The mechanism by which PD therapy restores brain function is still unclear. However, clinical feedback indicating its rapid effects suggests several possibilities. First, the presence of cortical vessels and the periosteal vascular network may serve as the anatomical basis for the efficacy of PD treatment. 7 Second, in strokes, a crucial target for recovery is the penumbra—the area surrounding the infarction. This region, characterized by electrical depletion yet preserved energy metabolism, holds potential for recovery. 3 The penumbra, having survived the initial injury, can reorganize to facilitate healing. More importantly, local and remote unaffected areas may also serve as targets. 3 PD may enhance the function of the penumbra and related regions by promoting neuroplastic changes. Finally, findings from the Cranial Bone Maneuver program indicate that PD may enhance nerve function in stroke patients by promoting the regeneration of meningeal lymphatic vessels, improving their drainage capacity, and effectively alleviating neuroinflammation. 8 We propose that PD is a novel alternative surgical option for treating neurological dysfunction in stroke patients. Key advantages include: i) the small incision minimizes complications associated with skin incisions; ii) the traction devices needed for periosteal stretching consist only of screws and standard locking plates, thereby imposing minimal economic burden on patients; iii) using periosteal infiltration local anesthesia with PD can decrease anesthesia-related complications, reduce the need for general anesthesia, and significantly alleviate the strain on patients' vital organs. However, the results are limited by the small sample size and short follow-up period. Additionally, the optimal settings for retractor parameters (e.g., force applied and duration) and the specific patient subgroups most likely to benefit remain unclear. The potential synergistic effects of PD combined with other treatments also warrant further exploration. Further studies are needed to answer these questions. In conclusion, the preliminary results of our study show that the PD technique has surprising efficacy in improving functional recovery in stroke patients, with great prospects for future application. However, more in-depth basic and clinical studies are needed to optimize protocols and explore potential mechanisms, providing a stronger scientific basis for treating neurological diseases. Ethics statement Reviewed and approved by the institutional research ethics boards of Yueyang Renya Rehabilitation Hospital (Yueyang, China) on June 21, 2024; This study was conducted in accordance with the Declaration of Helsinki. Consent to publish Written informed consent has been obtained from the patients for publication of the case report and accompanying images. The patients in this manuscript have given written informed consent to the publication of their case details. Data availability statement No data are associated with this article. References 1. Go AS, Mozaffarian D, Roger VL, et al. : Heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation. 2014 2014-1-21; 129 (3): e28–e292. PubMed Abstract | Publisher Full Text 2. Rathore SS, Hinn AR, Cooper LS, et al. : Characterization of incident stroke signs and symptoms: findings from the atherosclerosis risk in communities study. Stroke. 2002 2002-11-1; 33 (11): 2718–2721. [Journal Article; Research Support, U.S. Gov't, P.H.S]. PubMed Abstract | Publisher Full Text 3. Cassidy JM, Cramer SC: Spontaneous and Therapeutic-Induced Mechanisms of Functional Recovery After Stroke. Transl. Stroke Res. 2017 2017-2-1; 8 (1): 33–46. [Journal Article; Research Support, N.I.H., Extramural; Review]. PubMed Abstract | Publisher Full Text | Free Full Text 4. Shehjar F, Maktabi B, Rahman ZA, et al. : Stroke: Molecular mechanisms and therapies: Update on recent developments. Neurochem. Int. 2023 2023-1-1; 162 : 105458. [Journal Article; Research Support, N.I.H., Extramural; Review]. PubMed Abstract | Publisher Full Text | Free Full Text 5. Yuan Y, Ding X, Lu H, et al. : A novel and alternative treatment method for moderate diabetic foot ulcer: tibial periosteal distraction. J. Orthop. Surg. Res. 2024 2024-12-30; 19 (1): 889. PubMed Abstract | Publisher Full Text 6. Wang J, Huang X, Wang P, et al. : Periosteal distraction for foot preservation contributes to favorable clinical effects and prognosis in a foot ulcer patient with critical limb ischemia after multiple operations. Am. J. Transl. Res. 2023 2023-1-20; 15 (5): 3766–3772. PubMed Abstract 7. Chanavaz M: Anatomy and histophysiology of the periosteum: quantification of the periosteal blood supply to the adjacent bone with 85Sr and gamma spectrometry. J. Oral Implantol. 1995 1995-1-19; 21 (3): 214–219. PubMed Abstract 8. Lu X, Bai S, Feng L, et al. : Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function. Alzheimers Dement. 2025 2025-1-30; e14518. Comments on this article Comments (0) Version 1 VERSION 1 PUBLISHED 11 Apr 2025 ADD YOUR COMMENT Comment Author details Author details 1 Department of Cardiac and Vascular Surgery, Yueyang Central Hospital, No.39 Yuedong Road, Yueyang, China, Yueyang, China 2 Department of Dermatology, Xiangya Hospital, Central South University, Hu Nan Key Laboratory of Aging Biology, Changsha, China, changsha, China 3 Department of Surgery, Yueyang Renya Rehabilitation Hospital, No.68 Rong Road, Yueyang county, China, Yueyang, China 4 Department of Neurology, Yueyang Central Hospital, No.39 Yuedong Road, Yueyang, China, Yueyang, China 5 Department of Neurosurgery, Yueyang Central Hospital, No.39 Yuedong Road, Yueyang, China, Yueyang, China 6 Department of Rehabilitation Medicine, Yueyang Central Hospital, No.39 Yuedong Road, Yueyang, China, Yueyang, China Yi You MD Roles: Data Curation, Writing – Original Draft Preparation Jundong Huang MD Roles: Writing – Original Draft Preparation Xiangkai Zhou MD Roles: Data Curation Yan Ma MD Roles: Data Curation Mingqi Yi MD Roles: Data Curation Huiyan Liu MD Roles: Data Curation Jing Luo MD Roles: Data Curation Fang Wei MD Roles: Data Curation Wei Shi MD,PhD Roles: Supervision, Validation Naxin Zeng MD Roles: Data Curation, Supervision, Validation Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (1) version 1 Published: 11 Apr 2025, 14:426 https://doi.org/10.12688/f1000research.162479.1 Copyright © 2025 You MD Y et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article You MD Y, Huang MD J, Zhou MD X et al. Periosteal distraction technology for stroke recovery: A game changer for neurorehabilitation? [version 1; peer review: awaiting peer review] . 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