Castleman disease with plasmacytoma transformation: a case report

Background: Castleman disease is a rare lymphoproliferative disorder that shares similar symptoms, signs, and pathological features with malignant lymphoma. Diagnosis of CD primarily depends on pathological examinations, and CD can be histopathologically classified into hyaline vascular, plasma cell, or mixed types. The hyaline vascular type of unicentric CD is the most common, accounting for 80%-90% of cases.[3] Treatment of Castleman's disease includes surgical resection, simple chemotherapy, surgery combined with chemotherapy, or chemotherapy combined with radiotherapy, etc. Case Presentation : Here, we report the case of a 68-year-old man with bilateral cervical lymphadenopathy who was pathologically diagnosed with multicentric Castleman disease(mixed type) with plasmacytoma. He underwent a bilateral cervical lymphadenectomy, which resulted in a promising prognosis. Conclusions: : Castleman disease with plasmacytoma occurs only rarely, and its pathological features are very special. To date, it has been rarely reported worldwide, and its clinical characteristics are still unclear.