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This study investigated the expression levels of nerve injury-induced protein 1, interleukin-1β, and protein gene product 9.5 in ectopic endometrial tissues from patients with ovarian endometriosis compared to in situ and normal tissues. The researchers found that these proteins were significantly upregulated in both ectopic and in situ endometrium relative to normal controls, with peripheral IL-1β also elevated in patients. Furthermore, higher expression of Ninj1 and PGP-9.5 was observed in patients experiencing dysmenorrhea, suggesting a link between these markers and pain mechanisms. This paper is centrally about endometriosis — specifically examining molecular markers associated with ectopic lesion development and dysmenorrhea.
Abstract
Objective To investigate the expression levels of nerve injury-induced protein 1 (Ninjl), interleukin-1β(IL-1β), and protein gene product 9.5 (PGP-9.5) in the ectopic endometrial tissues of patients with endometriosis (EMT) and their relationship with dysmenorrhea. Methods Ectopic endometrial tissues from 40 patients with ovarian EMT diagnosed by post-ope-rative gynecological pathological examination in our hospital from April 2020 to April 2021 were selected as group A. In situ endo-metrial tissues from 20 of these patients were obtained as group B. Normal endometrial tissues from 20 patients with uterine fi-broids in the same period were collected as group C. Group A was divided into a dysmenorrhoea subgroup and a non-dysmenorrhoea subgroup according to the presence or absence of dysmenorrhoea, with 20 patients per subgroup. The expression levels of Ninj1, IL-1β, and PGP-9.5 in the endometrial tissues of groups A, B, and C were measured by immunohistochemistry, and their correlation was analyzed. The expression level of IL-1β in the peripheral blood of patiens in groups A and C was measured by enzyme-linked immunosorbent assay. Results The expression level of IL-1β in the peripheral blood of patients in group A was signifi-cantly higher than that in group C (t=-4.184,P<0.05). The positive expression rates of three proteins in the endometrial tissues were significantly increased in groups A and B compared with group C (χ2=4.286-19.394, P<0.05)and in group A compared with group B (χ2=4.149-5.272,P<0.05). The positive expression rates of Ninjl and PGP-9.5 proteins in the endometrial tissues were significantly higher in the dysmenorrhoea subgroupthan in the non-dysmenorrhoea subgroup (χ2=8.533,11.905,P<0.05). The expression of Ninj1 was positively correlated with the expression of PGP-9.5 and IL-1β in the endometrial tissues of group A (r=0.733, 0.628,P<0.05). Conclusion Ninjl, IL-1β, and PGP-9.5 are highly expressed in the ectopic endometrial tissues,which may be involved in the occurrence and development of EMT. The positive expression rates of both Ninjl and PGP-9.5 in the endometrial tissues of the dysmenorrhoea subgroup were higher than those in the non-dysmenorrhoea subgroup, which may be closely related to the mechanism of EMT pain.
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精准医学杂志 (Oct 2024)
Expression and significance of Ninj1, IL-1β and PGP-9.5 in ectopic endometrial tissues of patients with endometriosis
Abstract
Objective To investigate the expression levels of nerve injury-induced protein 1 (Ninjl), interleukin-1β(IL-1β), and protein gene product 9.5 (PGP-9.5) in the ectopic endometrial tissues of patients with endometriosis (EMT) and their relationship with dysmenorrhea. Methods Ectopic endometrial tissues from 40 patients with ovarian EMT diagnosed by post-ope-rative gynecological pathological examination in our hospital from April 2020 to April 2021 were selected as group A. In situ endo-metrial tissues from 20 of these patients were obtained as group B. Normal endometrial tissues from 20 patients with uterine fi-broids in the same period were collected as group C. Group A was divided into a dysmenorrhoea subgroup and a non-dysmenorrhoea subgroup according to the presence or absence of dysmenorrhoea, with 20 patients per subgroup. The expression levels of Ninj1, IL-1β, and PGP-9.5 in the endometrial tissues of groups A, B, and C were measured by immunohistochemistry, and their correlation was analyzed. The expression level of IL-1β in the peripheral blood of patiens in groups A and C was measured by enzyme-linked immunosorbent assay. Results The expression level of IL-1β in the peripheral blood of patients in group A was signifi-cantly higher than that in group C (t=-4.184,P<0.05). The positive expression rates of three proteins in the endometrial tissues were significantly increased in groups A and B compared with group C (χ2=4.286-19.394, P<0.05)and in group A compared with group B (χ2=4.149-5.272,P<0.05). The positive expression rates of Ninjl and PGP-9.5 proteins in the endometrial tissues were significantly higher in the dysmenorrhoea subgroupthan in the non-dysmenorrhoea subgroup (χ2=8.533,11.905,P<0.05). The expression of Ninj1 was positively correlated with the expression of PGP-9.5 and IL-1β in the endometrial tissues of group A (r=0.733, 0.628,P<0.05). Conclusion Ninjl, IL-1β, and PGP-9.5 are highly expressed in the ectopic endometrial tissues,which may be involved in the occurrence and development of EMT. The positive expression rates of both Ninjl and PGP-9.5 in the endometrial tissues of the dysmenorrhoea subgroup were higher than those in the non-dysmenorrhoea subgroup, which may be closely related to the mechanism of EMT pain.
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