Curative effect of endostatin in rat models with endometriosis-induced low gestational function

Objective:To establish the rat model of endometriosis,observe the endometriosis-induced low gestational status,explore the curative effect of endostatin(Endostar).Methods:The SD rat models of endometriosis were established by autologous transplantation method,then the rats were randomly divided into model group,Danazol group,and Endostar group,8 rats underwent sham operation.The rats were treated with drug at four weeks after operation for fourteen days,half of rats from each group were selected at random and then killed,the serum samples were obtained to detect the levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol,and progesterone;the sections of ectopic pregnancy focuses were obtained to observe the general situation,immunohistochemistry was used to detect the expression of vascular endothelial growth factor(VEGF).The remaining rats were caged together with male rats to observe the gestational function.Results:A total of 32 rats were operated,and 28 rats succeeded.The expression levels of VEGF in sham operation group,Danazol group,and Endostar group were significantly lower than that in model group(P0.05).There was significant difference in the serum levels of FSH,LH,estradiol,and progesterone between the first three groups and model group(P0.05).The rats in model group were in low gestational status.There was significant difference in conception situation between Endostar group and Danazol group(P0.05).Conclusion:The success rate of SD rat models of endometriosis is high,the rat models can simulate endometriosis-induced low gestational status,Endostar has a certain therapeutic effect for endometriosis-induced low gestational function,and it has less adverse reactions.