COVID-19 vaccine effectiveness against hospitalisation in older adults, VEBIS hospital network, Europe, September 2024--May 2025

2025 · doi:10.22541/au.175390396.68088018/v1
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Abstract

We estimated COVID-19 vaccine effectiveness (VE) against PCR-confirmed SARS-CoV-2 hospitalisation in patients ≥60 years with severe acute respiratory infection, using a multicentre, test-negative case-control study across six European countries between September 2024 and May 2025. We included 352 cases (115 vaccinated; 33%) and 9 980 controls (5 024 vaccinated; 50%). VE was 42% (95%CI:15;61) 14–59 days post-vaccination, 32% (95%CI: -1;54) at 60–119 days, and 36% (95%CI: 2;60) at 120–179 days, and no effect thereafter. Among adults aged 60–79 and ≥80 years, we observed moderate VE against COVID-19 hospitalisation for up to 2 and 4 months, respectively. Supplementary Material File (manuscript_iorv.docx) - Download - 523.48 KB Information & Authors Information Version history Copyright This work is licensed under a Non Exclusive No Reuse License. Collection

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Authors Metrics & Citations Metrics Article Usage 461views 190downloads Citations Download citation Madelyn Castro, Nuno Verdasca, Susana Monge, et al. COVID-19 vaccine effectiveness against hospitalisation in older adults, VEBIS hospital network, Europe, September 2024--May 2025. Authorea. 30 July 2025. DOI: https://doi.org/10.22541/au.175390396.68088018/v1 DOI: https://doi.org/10.22541/au.175390396.68088018/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu.

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last seen: 2026-05-20T01:45:00.602351+00:00