A Five-time-recurring Kawasaki Disease: A Case Report and Literature Review

Background: Five-time-recurring Kawasaki Disease without any cardiovascular complications is relatively rare and was first described in 2021.Case presentationWe describe a case of five-time-recurring Kawasaki disease (KD) in a 6-year-old boy who had been diagnosed with typical KD without cardiac involvement at age 25 months. Subsequently, the child was hospitalized with KD other 4 times when he was 40, 47, 59, and 66-month-old respetively. In each episode, the boy was characterized by an abrupt intermittently high fever but typical cutaneous and mucosal manifestations were not always presented. Clinical improvement was successfully obtained after intravenous immunoglobulin and (or) aspirin in each time without any cardiovascular damage. Diagnosis was difficult to establish because of the incomplete clinical features and the recurrence of the disease.ConclusionPhysicians need to be aware of the differential diagnosis of relapsing KD should be kept in mind while treating a patient with a history of KD. Five-time-recurring Kawasaki Disease is infrequent and will increase the likelihood of poor clinical outcomes if not diagnosed and managed promptly.