Cotton Fabric Incorporated with β-Cyclodextrin/Ketoconazole/Ag-NPs Generating Outstanding Antifungal and Antibacterial Performances

Abstract The influence of Ketoconazole and β-CD/Ketoconazole was previously reported on cotton fabric as fungal skincare; however, the impact of nanosilver on the antifungal and antibacterial properties of the same products is unknown. Here, silver NPs were synthesized on β-CD/KZ composites and then attached to the cotton using a cross-linking agent. The nanocomposites and treated fabrics were analyzed by UV-vis, dynamic light scattering (DLS), zeta-potential and FE-SEM. The drug delivery and cytotoxicity of the products were also studied. The nanocomposites antimicrobial efficiency was examined on Candida albicans and Aspergillus niger as fungi and E. coli & S. aureus as bacteria. The synthesis of Ag-NPs on the β-CD/KZ amplifies both antifungal and antibacterial efficiencies. This also extends the drug regular release time for medical and drug delivery purposes. Having tremendous antimicrobial activities without cytotoxicity effects and regular release time of drug with excellent washing durability of treated samples make it suitable for medical applications likewise wound dressings and sportswear designed for sensitive skin.