JARID1A is associated with improved prognosis in epithelial high-grade ovarian cancer

JARID1A is associated with improved prognosis in epithelial high-grade ovarian cancer | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article JARID1A is associated with improved prognosis in epithelial high-grade ovarian cancer Katharina Leitner, Christoph Ebner, Katharina Steger, Barin Feroz, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8419164/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 5 You are reading this latest preprint version Abstract JARID1A is a histone demethylase involved in cell cycle regulation, epigenetic remodeling, and cancer progression. While it has been associated with tumor-promoting processes such as epithelial-to-mesenchymal transition and chemoresistance in several cancer types, its exact role in ovarian cancer remains poorly defined. In this study, we analyzed JARID1A mRNA-expression in a well-characterized cohort of 179 epithelial ovarian cancers (OC), with a focus on advanced high-grade serous and endometrioid subtypes (HGOC). High JARID1A expression was significantly associated with unfavorable tumor features, including advanced FIGO stage (P=0.016), high tumor grade (P<0.001) and adverse molecular markers. However, prognostically it was linked to improved progression-free and overall survival (P=0.001 and P=0.001, respectively) and remained an independent predictor of favorable prognosis in multivariate analysis (HR=0.44 for PFS (P=0.001), HR=0.49 for OS (P=0.006). This was also corroborated by validation with external data sets. It is tempting to speculate that in advanced HGOC high JARID1A expression may contribute to growth-inhibitory mechanisms or less proliferative tumor states, despite its association with established markers of aggressiveness. Taken together, our findings identify JARID1A mRNA-expression as a favorable prognostic marker, whose therapeutic inhibition should, at present, be approached with caution in high-grade ovarian cancer. JARID1A ovarian cancer senescence epigenetics prognosis survival Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Reviewers agreed at journal 07 May, 2026 Reviewers invited by journal 08 Jan, 2026 Editor assigned by journal 24 Dec, 2025 Submission checks completed at journal 23 Dec, 2025 First submitted to journal 21 Dec, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8419164","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":571631460,"identity":"3fdf31b7-2ce5-4e44-8755-90dbece1c304","order_by":0,"name":"Katharina Leitner","email":"","orcid":"","institution":"Innsbruck Medical University","correspondingAuthor":false,"prefix":"","firstName":"Katharina","middleName":"","lastName":"Leitner","suffix":""},{"id":571631463,"identity":"6a26c6fc-f0e8-4425-84e3-a8b04959d828","order_by":1,"name":"Christoph Ebner","email":"","orcid":"","institution":"Innsbruck Medical University","correspondingAuthor":false,"prefix":"","firstName":"Christoph","middleName":"","lastName":"Ebner","suffix":""},{"id":571631465,"identity":"ee5649a4-7931-49cf-a95c-522a3aa23f8f","order_by":2,"name":"Katharina Steger","email":"","orcid":"","institution":"Innsbruck Medical University","correspondingAuthor":false,"prefix":"","firstName":"Katharina","middleName":"","lastName":"Steger","suffix":""},{"id":571631467,"identity":"533ccd98-9395-4ac7-8a3f-6861be023ffc","order_by":3,"name":"Barin Feroz","email":"","orcid":"","institution":"Innsbruck Medical University","correspondingAuthor":false,"prefix":"","firstName":"Barin","middleName":"","lastName":"Feroz","suffix":""},{"id":571631470,"identity":"b2318fa3-bd98-4d40-afc6-d22b6e702997","order_by":4,"name":"Miriam Emmelheinz","email":"","orcid":"","institution":"Innsbruck Medical University","correspondingAuthor":false,"prefix":"","firstName":"Miriam","middleName":"","lastName":"Emmelheinz","suffix":""},{"id":571631472,"identity":"f0b5b38b-d9dc-45e9-989e-6923346e90b8","order_by":5,"name":"Daniel Reimer","email":"","orcid":"","institution":"Innsbruck Medical University","correspondingAuthor":false,"prefix":"","firstName":"Daniel","middleName":"","lastName":"Reimer","suffix":""},{"id":571631476,"identity":"28dca96f-0ac5-4726-b898-63396aeffc3e","order_by":6,"name":"Heidi Fiegl","email":"","orcid":"","institution":"Innsbruck Medical University","correspondingAuthor":false,"prefix":"","firstName":"Heidi","middleName":"","lastName":"Fiegl","suffix":""},{"id":571631479,"identity":"e97f841e-2dd1-4d2d-9cbc-b2915974b5df","order_by":7,"name":"Christian Marth","email":"","orcid":"","institution":"Innsbruck Medical University","correspondingAuthor":false,"prefix":"","firstName":"Christian","middleName":"","lastName":"Marth","suffix":""},{"id":571631481,"identity":"a0d9aee8-35bf-443c-a197-9319cf815289","order_by":8,"name":"Alain G. 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While it has been associated with tumor-promoting processes such as epithelial-to-mesenchymal transition and chemoresistance in several cancer types, its exact role in ovarian cancer remains poorly defined.\u003c/p\u003e\n\u003cp\u003eIn this study, we analyzed \u003cem\u003eJARID1A\u003c/em\u003e mRNA-expression in a well-characterized cohort of 179 epithelial ovarian cancers (OC), with a focus on advanced high-grade serous and endometrioid subtypes (HGOC).\u003c/p\u003e\n\u003cp\u003eHigh \u003cem\u003eJARID1A\u003c/em\u003e expression was significantly associated with unfavorable tumor features, including advanced FIGO stage (P=0.016), high tumor grade (P\u0026lt;0.001) and adverse molecular markers. However, prognostically it was linked to improved progression-free and overall survival (P=0.001 and P=0.001, respectively) and remained an independent predictor of favorable prognosis in multivariate analysis (HR=0.44 for PFS (P=0.001), HR=0.49 for OS (P=0.006). This was also corroborated by validation with external data sets.\u003c/p\u003e\n\u003cp\u003eIt is tempting to speculate that in advanced HGOC high \u003cem\u003eJARID1A\u003c/em\u003e expression may contribute to growth-inhibitory mechanisms or less proliferative tumor states, despite its association with established markers of aggressiveness. Taken together, our findings identify \u003cem\u003eJARID1A\u003c/em\u003emRNA-expression as a favorable prognostic marker, whose therapeutic inhibition should, at present, be approached with caution in high-grade ovarian cancer.\u003c/p\u003e","manuscriptTitle":"JARID1A is associated with improved prognosis in epithelial high-grade ovarian cancer","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-01-12 22:40:57","doi":"10.21203/rs.3.rs-8419164/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"reviewerAgreed","content":"300600613933693855477396502897297407518","date":"2026-05-07T08:04:10+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2026-01-08T16:27:55+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-12-24T05:02:55+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-12-24T02:13:40+00:00","index":"","fulltext":""},{"type":"submitted","content":"Journal of Ovarian Research","date":"2025-12-21T19:07:20+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"journal-of-ovarian-research","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"jovr","sideBox":"Learn more about [Journal of Ovarian Research](http://ovarianresearch.biomedcentral.com)","snPcode":"13048","submissionUrl":"https://submission.nature.com/new-submission/13048/3","title":"Journal of Ovarian Research","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"503d9626-025f-4d0c-aa8a-619dd9042cb6","owner":[],"postedDate":"January 12th, 2026","published":true,"recentEditorialEvents":[{"type":"reviewerAgreed","content":"300600613933693855477396502897297407518","date":"2026-05-07T08:04:10+00:00","index":31,"fulltext":""}],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2026-01-12T22:40:57+00:00","versionOfRecord":[],"versionCreatedAt":"2026-01-12 22:40:57","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8419164","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8419164","identity":"rs-8419164","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}