In vitro Maturation of Oocytes with Consecutive Clinical Pregnancy after Accidental Premature Ovulation Induction-A Rescue Strategy in Art.

Findeklee S, Hachenberg J, Kienast K
Acta endocrinologica (Bucharest, Romania : 2005) · 2021 · doi:10.4183/aeb.2021.106 · PMID:34539917 · PMC8417485
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This case report describes a successful rescue strategy for accidental premature ovulation induction, where immature oocytes retrieved 24 hours after triggering were matured in vitro, resulting in a healthy ongoing pregnancy.

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This case report describes a 31-year-old patient who experienced accidental premature ovulation induction during an assisted reproductive technology cycle. The clinical team performed oocyte retrieval twenty-four hours after the trigger shot and successfully matured the immature oocytes in vitro for over twelve hours. This rescue strategy resulted in a healthy, ongoing pregnancy, demonstrating that in vitro maturation can be a viable alternative to cycle cancellation when ovulation occurs prematurely. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

BackgroundThe implementation of assisted reproductive techniques (ART) is a complex treatment requiring both a good cooperation between various professional groups in the fertility centre, and the patient's and her partner's cooperation. Accordingly, there are many sources of failure, such as using the wrong medication or not considering optimal times. If there is an artificial application of the ovulation induction injection, the success of the treatment is endangered and in some cases the cycle is discontinued, if the patient failed to administer the drug correctly. An alternative to cycle cancellation might be the maturation of the oocytes in vitro.We reporton a 31-year-old patient in whom we performed an oocyte retrieval procedure 24 hours after triggering ovulation followed by in vitro maturation of the immature oocytes over a period of more than 12 h. The treatment resulted in a healthy, ongoing pregnancy.
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- Login - Register - Home/Current Issue - About the journal - Editorial board - Online submission - Instructions for authors - Subscriptions - Foundation Acta Endocrinologica - Archive - Contact Romanian Academy The Publishing House of the Romanian Academy ACTA ENDOCRINOLOGICA (BUC) The International Journal of Romanian Society of Endocrinology / Registered in 1938in Web of Science Master Journal List Acta Endocrinologica(Bucharest) is live in PubMed Central Journal Impact Factor - click here. This Article Services Google Scholar PubMed Acta Endocrinologica (Buc) Findeklee S, Hachenberg J, Kienast K In Vitro Maturation of Oocytes with Consecutive Clinical Pregnancy after Accidental Premature Ovulation Induction-A Rescue Strategy in ART Acta Endo (Buc) 2021, 17 (1): 106-110doi: 10.4183/aeb.2021.106 Background. The implementation of assisted reproductive techniques (ART) is a complex treatment requiring both a good cooperation between various professional groups in the fertility centre, and the patient’s and her partner’s cooperation. Accordingly, there are many sources of failure, such as using the wrong medication or not considering optimal times. If there is an artificial application of the ovulation induction injection, the success of the treatment is endangered and in some cases the cycle is discontinued, if the patient failed to administer the drug correctly. An alternative to cycle cancellation might be the maturation of the oocytes in vitro. We report on a 31-year-old patient in whom we performed an oocyte retrieval procedure 24 hours after triggering ovulation followed by in vitro maturation of the immature oocytes over a period of more than 12 h. The treatment resulted in a healthy, ongoing pregnancy. Keywords: artificial ovulation induction, assisted reproductive techniques, in vitro oocyte maturation. Correspondence: Sebastian Findeklee MD, Kinderwunschzentrum Niederrhein Mönchengladbach/Krefeld, Reproductive Medicine, Madrider Straße 6, Mönchengladbach, Northrhine-Westphalia, 41069, Germany, E-mail: [email protected]

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