Clinical Significance of CA125 in the Diagnosis of Endometriosis

Objective To investigate the clinical significance of CA125 in diagnosis of endometriosis and to explore the possible related factors influencing CA125 level. Methods 150 cases diagnosed as ovarian cysts or adenomyosis patients were involved in this study which including 69 cases of cyst of the ovary( Group A),52 cases of ovarian cyst( Group B),29 cases of uterine adenomyosis( Group C). The serum CA125 levels were determined and clinical related factors were analyzed. Results The serum CA 125 levels in Group A and Group C were significantly higher than that of Group B( P 0. 01). There was no significantly difference on CA 125 levels between Group A and Group C( P 0. 05). The CEA and AFP levels in three groups had no significant difference( P 0. 05). The positive rate of CA 125 in Group A and Group C was significantly higher than that of Group B( P 0. 05). The higher level of CA125 showed higher r AFS staging( P 0. 05). The CA125 level was positively related with the staging of the adhesion score of r AFS,but not correlated with the incidence of dysmenorrhea and infertility. Conclusion The serum CA125 levels can be used as an index to identify ovarian cysts,endometriotic cyst and uterine adenomyosis,and it might have important reference value for preoperative evaluation of the severity of endometriosis.