The study on the effects of mifepristone on adenomyosis cells in vitro.

Objective:To observe the effects of mifepristone on adenomyosis cells.Methods:Using MTT assay,the growth state of primary cell culture from tissues of 11 cases of adenomyosis was detected,The cells of each case were divided into four groups,three dosage groups were 1.25mg/L,2.5mg/L,5mg/L mifepristone respectively and one control group and surveyed their OD value through 52 hours culture.Results:By contrasting the results,the OD values of 1.25mg/L,2.5mg/L,5mg/L and control group were 0.219±0.044,0.185±0.038,0.152±0.033 and 0.262±0.0678 respectively.The OD value of 5mg/L group had significant difference from that of 1.25mg/L group(P0.01) and 5mg/L,2.5mg/L group had significant difference from the control group(P0.01).The inhibition rate of cell growth showed that 2.5mg/L group(IR=29.4%)was 1.79 times 1.25mg/L group(IR=16.4%),and 5mg/L group(IR=42.0%) Was 1.43 times 2.5mg/L group.Conclusions:Mifepristone could suppress the growth of adenomyosis cells in vitro.There was positive correlations between the inhibition growth ability and the mifepristone concentration.