Impact of Surgery on Survival in Breast Cancer with Bone Metastases: a SEER database retrospective analysis

Abstract Purpose It was controversial to operate on the primary site of breast cancer with simple bone metastasis，we found that the surgery could improve survival in patients with breast cancer with bone metastases via a SEER database retrospective analysis.Method Totolly 2917 cases of breast cancer with bone metastasis, first diagnosed between 2010 and 2015 in the National Cancer Institute surveillance, Epidemiology, and Results Database (SEER).We assessed the effect of different surgical procedures on survival and prognosis by the correlation statistics.Results Compared with the non-surgical group , the prognosis of patients on the primary tumor surgical group shows the statistical significance (c2 = 146.023, P < 0.001), the survival benefit of the breast-conserving group was the highest for 70 months(c2=157.117,P<0.001). Compared with the non-surgery group, the median OS of primary surgery group was: HR=0.525, 95%CI=0.467-0.590,P<0.001. In the breast-conserving group, the median operative OS: HR=0.394, 95%CI=0.325-0.478,P<0.001. Conclusion: This study showed that primary surgery could improve the prognosis and overall survival of women with advanced breast cancer with bone metastasis alone. Under the condition of low tumor burden, breast conserving surgery was a better choice.