Effects of PKF 115–584 on cell migration and invasion.

Sachiko Matsuzaki (405488), Claude Darcha (405489)
2015 · doi:10.1371/journal.pone.0061690.g002 · W6941956570
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This study investigated the in vitro effects of PKF 115–584, a small-molecule antagonist of the Tcf/ß-Catenin complex, on cell migration and invasion. The researchers compared endometrial epithelial and stromal cells from patients with endometriosis against those from patients without the condition across different menstrual phases. Results indicated that treatment with PKF 115–584 significantly reduced the number of migrated and invasive cells in both epithelial and stromal populations. This paper is centrally about endometriosis — specifically examining how inhibiting the Wnt signaling pathway affects the migratory and invasive potential of endometrial cells in this disease context.

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Abstract

A, B: Number of migrated cells/mm2 in non-treated and PKF 115–584–treated endometrial epithelial (A) and stromal (B) cells of patients with and without endometriosis. C, D: Number of invasive cells/mm2 in non-treated and PKF 115–584–treated endometrial epithelial (C) and stromal (D) cells of patients with and without endometriosis. Results are presented as the mean+SEM. M: menstrual phase, P: proliferative phase, S: secretory phase. Endo (+): Endometrium of patients with endometriosis (M: n = 4, P: n = 8, S: n = 8). Endo (–): endometrium of patients without endometriosis (M: n = 4, P: n = 5, S: n = 5). a: p<.05 versus PKF 115–584–treated endometrial epithelial or stromal cells of patients without endometriosis.
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In Vitro Effects of a Small-Molecule Antagonist of the Tcf/ß-Catenin Complex on Endometrial and Endometriotic Cells of Patients with Endometriosis Figure 2 Effects of PKF 115–584 on cell migration and invasion. A, B: Number of migrated cells/mm2 in non-treated and PKF 115–584–treated endometrial epithelial (A) and stromal (B) cells of patients with and without endometriosis. C, D: Number of invasive cells/mm2 in non-treated and PKF 115–584–treated endometrial epithelial (C) and stromal (D) cells of patients with and without endometriosis. Results are presented as the mean+SEM. M: menstrual phase, P: proliferative phase, S: secretory phase. Endo (+): Endometrium of patients with endometriosis (M: n = 4, P: n = 8, S: n = 8). Endo (–): endometrium of patients without endometriosis (M: n = 4, P: n = 5, S: n = 5). a: p<.05 versus PKF 115–584–treated endometrial epithelial or stromal cells of patients without endometriosis.

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endometriosis

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