The role of mesothelin (MSLN) in bone homeostasis

The role or Mesothelin (MSLN) in bone homeostasis is not known. Here, we showed that MSLN KO mice display an osteoporotic phenotype, accompanied with an increased osteoclast number. Full-length MSLN suppresses osteoclast differentiation and bone resorption. Additionally, MSLN deficiency leads to attenuated osteoblast differentiation and function. Treatment with full-length MSLN in vivo protects against osteolysis induced by calvarial lipopolysaccharide (LPS) injection. The exact molecular mechanisms by which MSLN regulates bone cells remains to be fully elucidated. Nevertheless, MSLN is a novel regulator in bone remodelling and may represent a potential therapeutic target for the treatment of bone disorders.