Three cases of obstructed hemi-vagina and ipsilateral renal agenesis syndrome complicated with different severities of endometriosis

This paper reports three women diagnosed with obstructed hemi-vagina and ipsilateral renal agenesis (OHVIRA) syndrome, a Müllerian/Wolffian duct anomaly characterized by an obstructed hemi-vagina (which can cause hematocolpos) and ipsilateral renal anomaly, along with varying degrees of didelphic uterine anomalies. Across the cases, the authors describe different clinical courses and correspondingly different severities of pelvic endometriosis, framing endometriosis as a complication arising from the reproductive tract obstruction. They suggest that the findings may indicate a relationship between endometriosis pathogenesis and asymmetrical obstructive Müllerian anomalies, but the evidence is limited by the small case-series format. This paper is centrally about endometriosis — it presents OHVIRA cases with varying severities of pelvic endometriosis and links these patterns to asymmetrical obstructive Müllerian anomalies.

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