Investigation of IL-17Agene Polymorphism (Rs2275913) with Infertility in Southern Iranian Women

Mohaddeseh Davoodi, Sirous Naeimi, Mohammad Mahdi Moghanibashi
In: Journal of Shahid Sadoughi University of Medical Sciences · 2020 · doi:10.18502/ssu.v28i4.3768 · W3044977206
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This case-control study found that the IL-17A gene polymorphism rs2275913A allele is significantly correlated with infertility in Southern Iranian women, particularly with polycystic ovarian syndrome and fallopian tube disorders.

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This paper investigates whether the IL-17A gene polymorphism rs2275913 is associated with infertility among women from southern Iran. The provided record identifies the study population and genetic variant but does not include the study design, sample size, genotyping methods, results, limitations, or conclusions. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Introduction: Estimates show that about 3-7% of all couples or women around the world have an unsolved infertility problem. Interleukin-17 (IL-17) is a pro inflammatory cytokine involved in the expression of many inflammatory mediators. The aim of this study was to investigate the relationship between (rs2275913G/A) IL-17A gene polymorphism with infertility in women. Methods: This case-control study was carried out on 200 patients with infertility and 200 healthy individuals whose conditions were confirmed by an infertility specialist. Genomic DNA was extracted from peripheral blood using the Salting Out method and K Proteinase. To examine the position of rs2275913 polymorphism the RFLP-PCR method was used. Data were statistically analyzed using SPSS software Ver. 20, Chi-square and Hardy-Weinberg tests. The P-values ≤ 0.05 was considered significant. Results: The results showed that allele A at position rs2275913 had a significant correlation with infertility (P = 0.000). It was found the patients with polycystic ovarian syndrome (P = 0.02) and Falobian tube disorders (P = 0.03) showed a significant relationship with rs2275913 Polymorphism. Conclusion: According to the results, it appears that the rs2275913 polymorphism of IL-17 gene is related to the infertility in women.
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Publication Journal of Shahid Sadoughi University of Medical Sciences Record type Journal article Published 22 July 2020 Authors Mohaddeseh Davoodi | Sirous Naeimi | Mohammad Mahdi Moghanibashi The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ssu.v28i4.3768', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'Journal of Shahid Sadoughi University of Medical Sciences', 'primary-resource': 'https://publish.kne-publishing.com/index.php/SSU/article/view/3768', 'tld': 'kne-publishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'http://jssu.ssu.ac.ir/article-1-4966-en.html', 'tld': 'ssu.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://publish.kne-publishing.com/index.php/SSU/article/view/3768', 'tld': 'kne-publishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '22 July 2020', 'publication': 'Journal of Shahid Sadoughi University of Medical Sciences', 'title': 'Investigation of IL-17Agene Polymorphism (Rs2275913) with Infertility in Southern Iranian Women', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ssu.v28i4.3768', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Mohaddeseh Davoodi | Sirous Naeimi | Mohammad Mahdi Moghanibashi', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ssu.v28i4.3768 JSON XML

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