Reveal the Alignment of Defects in a Metal-Organic Framework with Tunable Flexibility

Reveal the Alignment of Defects in a Metal-Organic Framework with Tunable Flexibility | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Help Center Sign In Submit a Preprint Cite Share Download PDF Article Reveal the Alignment of Defects in a Metal-Organic Framework with Tunable Flexibility Yao Fu, Alexander Forse, Zhengzhong Kang, Matthew Cliffe, Weicheng Cao, and 9 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1173692/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Crystalline materials are often considered to have rigid periodic lattices while soft materials are associated with flexibility and non-periodicity. The continuous evolution of metal-organic frameworks (MOFs) has erased the boundaries between these two distinct conceptions. Flexibility, disorder and defects have been found to be abundant in MOF materials with imperfect crystallinity, and their intricate interplay is poorly understood due to the limited strategies for characterizing disordered structures. Here, we apply advanced nuclear magnetic resonance (NMR) spectroscopy to elucidate the mesoscale structures in a defective MOF with a partially disordered lattice. We show that engineered defects can tune the degree of lattice flexibility by combining both ordered and disordered compartments. The one-dimensional alignment of defects is the key for the reversible topological transition. Full Text Additional Declarations There is NO Competing Interest. Supplementary Files FinalSINC.pdf Supplementary Information Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1173692","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":77159020,"identity":"d8ecbca6-d7c3-4c28-a361-7b96be582454","order_by":0,"name":"Yao Fu","email":"","orcid":"","institution":"Zhejiang University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yao","middleName":"","lastName":"Fu","suffix":""},{"id":77159021,"identity":"92c96177-a23f-434b-9ca1-541bd15cbacb","order_by":1,"name":"Alexander Forse","email":"","orcid":"","institution":"University of Cambridge","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Alexander","middleName":"","lastName":"Forse","suffix":""},{"id":77159022,"identity":"35a84f2b-7056-44f4-aaf3-76a5d23d77c1","order_by":2,"name":"Zhengzhong Kang","email":"","orcid":"","institution":"Zhejiang University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zhengzhong","middleName":"","lastName":"Kang","suffix":""},{"id":77159023,"identity":"37988340-2b39-4ba7-bb69-b219e3492a0e","order_by":3,"name":"Matthew Cliffe","email":"","orcid":"","institution":"University of Nottingham","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Matthew","middleName":"","lastName":"Cliffe","suffix":""},{"id":77159024,"identity":"b265f919-aa4a-4d93-a8e9-ff54d548fe1a","order_by":4,"name":"Weicheng Cao","email":"","orcid":"","institution":"Zhejiang University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Weicheng","middleName":"","lastName":"Cao","suffix":""},{"id":77159025,"identity":"f13b8655-23f7-4696-94d0-f23ec096c558","order_by":5,"name":"Jinglin Yin","email":"","orcid":"","institution":"Zhejiang University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jinglin","middleName":"","lastName":"Yin","suffix":""},{"id":77159026,"identity":"4248c542-5439-4d70-aef7-b131e9fe181f","order_by":6,"name":"Lina Gao","email":"","orcid":"","institution":"Zhejiang University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lina","middleName":"","lastName":"Gao","suffix":""},{"id":77159027,"identity":"c4447c20-b172-455f-ba16-4185039a57e4","order_by":7,"name":"Zhenfeng Pang","email":"","orcid":"https://orcid.org/0000-0003-1566-5454","institution":"Zhejiang University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zhenfeng","middleName":"","lastName":"Pang","suffix":""},{"id":77159028,"identity":"8a1bfbb4-7d8c-4cd7-827e-b5f203da2ad0","order_by":8,"name":"Tian He","email":"","orcid":"","institution":"Zhejiang University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Tian","middleName":"","lastName":"He","suffix":""},{"id":77159029,"identity":"0f0a453f-563c-46ff-8d62-84884ad9315d","order_by":9,"name":"Qinlong Chen","email":"","orcid":"","institution":"Zhejiang University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Qinlong","middleName":"","lastName":"Chen","suffix":""},{"id":77159030,"identity":"f4b93771-786e-4b58-b4b4-0f583b2c26ae","order_by":10,"name":"Qi Wang","email":"","orcid":"https://orcid.org/0000-0002-2246-1401","institution":"Zhejiang Uniersity","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Qi","middleName":"","lastName":"Wang","suffix":""},{"id":77159031,"identity":"00ab2c41-306f-4480-b9cf-e6dfa75b4c4d","order_by":11,"name":"Jeffrey Long","email":"","orcid":"https://orcid.org/0000-0002-5324-1321","institution":"University of California, Berkeley","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jeffrey","middleName":"","lastName":"Long","suffix":""},{"id":77159032,"identity":"8680f94b-f7a2-41db-8b5c-d15d0cead7bb","order_by":12,"name":"Jeffrey Reimer","email":"","orcid":"https://orcid.org/0000-0002-4191-3725","institution":"University of California, Berkeley","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jeffrey","middleName":"","lastName":"Reimer","suffix":""},{"id":77159033,"identity":"cd147dbc-f317-4f69-9c49-dfde05d409e5","order_by":13,"name":"Xueqian Kong","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAsklEQVRIiWNgGAWjYBACCQYGxgcMPCBmAvFamA1I1sImAWESq0VyRvK2yh8yhxn42XMMGH7uIEKLNM+xshsSPIcZJHveGDD2niFCixx7j9kNA6AWgxs5BsyMbcRoYeYxK0gAarEnWos00BaGAyBbJIjVItlzrFiygSedR+LMs4KDvcRokbiRvPHjzx5rOf725I0PfhKjBQgMGBh7IJF5gDgNIC0MP4hVOwpGwSgYBSMSAAC8Ny8K3c0G7QAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0002-1901-9073","institution":"Zhejiang University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Xueqian","middleName":"","lastName":"Kong","suffix":""}],"badges":[],"createdAt":"2021-12-15 11:31:24","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-1173692/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-1173692/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":20357143,"identity":"899b87ce-14ba-43ea-842e-935a4f618fa4","added_by":"auto","created_at":"2022-04-14 17:14:11","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2205227,"visible":true,"origin":"","legend":"Article File","description":"","filename":"FinalTextNC.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1173692/v1_covered.pdf"},{"id":20357136,"identity":"d4c89fcb-b3c5-4496-8559-761d71266b4d","added_by":"auto","created_at":"2022-04-14 17:14:05","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":27234965,"visible":true,"origin":"","legend":"Supplementary Information","description":"","filename":"FinalSINC.pdf","url":"https://assets-eu.researchsquare.com/files/rs-1173692/v1/07f51f1214235d4f856cb4a6.pdf"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e Competing Interest.","formattedTitle":"Reveal the Alignment of Defects in a Metal-Organic Framework with Tunable Flexibility","fulltext":[{"header":"Full Text","content":"This preprint is available for \u003ca href='/article/rs-1173692/latest.pdf' target='_blank'\u003edownload as a PDF\u003c/a\u003e."}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-1173692/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1173692/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Crystalline materials are often considered to have rigid periodic lattices while soft materials are associated with flexibility and non-periodicity. The continuous evolution of metal-organic frameworks (MOFs) has erased the boundaries between these two distinct conceptions. Flexibility, disorder and defects have been found to be abundant in MOF materials with imperfect crystallinity, and their intricate interplay is poorly understood due to the limited strategies for characterizing disordered structures. Here, we apply advanced nuclear magnetic resonance (NMR) spectroscopy to elucidate the mesoscale structures in a defective MOF with a partially disordered lattice. We show that engineered defects can tune the degree of lattice flexibility by combining both ordered and disordered compartments. The one-dimensional alignment of defects is the key for the reversible topological transition.","manuscriptTitle":"Reveal the Alignment of Defects in a Metal-Organic Framework with Tunable Flexibility","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2022-04-14 17:14:02","doi":"10.21203/rs.3.rs-1173692/v1","editorialEvents":[],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"91dc1f54-854c-483c-828e-dee7f963db09","owner":[],"postedDate":"April 14th, 2022","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2022-08-22T06:41:04+00:00","versionOfRecord":[],"versionCreatedAt":"2022-04-14 17:14:02","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-1173692","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1173692","identity":"rs-1173692","version":["v1"]},"buildId":"omnImTCwR2MFx8CMYfrG7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}