Endometriosis mouse models.

(A) In vivo magnetic resonance imaging (MRI), fat saturated T2-weighted Turbo spin echo images using a dedicated wrist coil at 3T: The red arrows indicate one experimentally induced-endometriotic implant in B6C3F1 and CD-1 nude mice. In a set of B6C3F1 mice, MRI was performed before and after antibody treatment. (B) Laparotomies performed in the CD-1 nude mice 4 (I, II) and 8 (III-V) weeks after the implantation; the black arrows denote the development of two peritoneal endometrial transplants that are shown indicated with arrows in images IV and V after peritoneal layer disruption. (C) Effect of endometrial tissue inoculation and treatment with anti-L1 mAb and control-antibody on body weight.