Endometriosis mouse models.

Cássia G. T. Silveira (492705), Dominique Finas (492706), Peter Hunold (492707), Frank Köster (492708), Katharina Stroschein (492709), Geraldine O. Canny (492710), Gerhard Moldenhauer (135129), Peter Altevogt (223601), Achim Rody (190314), Daniela Hornung (332203)
2015 · doi:10.1371/journal.pone.0082512.g001 · W6904195745
other OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-17 · read from full text ⓘ

This study investigates the L1 Cell Adhesion Molecule as a therapeutic target for endometriosis using murine models. Researchers induced endometriotic implants in B6C3F1 and CD-1 nude mice, utilizing magnetic resonance imaging to monitor lesion development before and after treatment with an anti-L1 monoclonal antibody. The results demonstrated that this antibody approach affected body weight and potentially influenced the progression of the experimental lesions compared to control groups. This paper is centrally about endometriosis — specifically evaluating a novel monoclonal antibody targeting the L1 cell adhesion molecule in mouse models of the disease.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

(A) In vivo magnetic resonance imaging (MRI), fat saturated T2-weighted Turbo spin echo images using a dedicated wrist coil at 3T: The red arrows indicate one experimentally induced-endometriotic implant in B6C3F1 and CD-1 nude mice. In a set of B6C3F1 mice, MRI was performed before and after antibody treatment. (B) Laparotomies performed in the CD-1 nude mice 4 (I, II) and 8 (III-V) weeks after the implantation; the black arrows denote the development of two peritoneal endometrial transplants that are shown indicated with arrows in images IV and V after peritoneal layer disruption. (C) Effect of endometrial tissue inoculation and treatment with anti-L1 mAb and control-antibody on body weight.
Full text 842 characters · extracted from oa-doi-fallback · click to expand
L1 Cell Adhesion Molecule as a Potential Therapeutic Target in Murine Models of Endometriosis Using a Monoclonal Antibody Approach Figure 1 (A) In vivo magnetic resonance imaging (MRI), fat saturated T2-weighted Turbo spin echo images using a dedicated wrist coil at 3T: The red arrows indicate one experimentally induced-endometriotic implant in B6C3F1 and CD-1 nude mice. In a set of B6C3F1 mice, MRI was performed before and after antibody treatment. (B) Laparotomies performed in the CD-1 nude mice 4 (I, II) and 8 (III-V) weeks after the implantation; the black arrows denote the development of two peritoneal endometrial transplants that are shown indicated with arrows in images IV and V after peritoneal layer disruption. (C) Effect of endometrial tissue inoculation and treatment with anti-L1 mAb and control-antibody on body weight.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

openalex
last seen: 2026-05-11T08:38:43.053463+00:00
License: CC0 · commercial use OK