Establishment of an animal model of endometriosis in macaca fascicularis

Objective To establish an animal model of endometriosis in macaca fascicularis.Methods Fifteen female macaca fascicularises were selected.Surgery was performed in the experimental group to collect endometrial tissues,which were then implanted into the pelvic omentum majus,douglas pouch,as well as uterus surface.A similar surgery was operated on the control group,in which the omentum majus was collected and implanted instead.Laparoscopic exploration was performed eight weeks and sixteen weeks postoperatively,followed by histopathological examination of suspected lesions.Results In the experimental group,eight female macaca fascicularis models of endometriosis were successfully established.Histopathological examination of suspected lesions revealed complete structure of the glands and stromal cells.Model establishment failed in the 5 subjects of the control group.Conclusion The endometriosis model of macaca fascicularis was successfully established,which adds a new animal choice to the research of endometriosis.