13006 Prevalence of Colorectal Polyps in Women with Endometrial Polyps, Synchronous Pathologies

The primary aim of this study was to evaluate the prevalence of colorectal polyps in patients with and without endometrial polyps, as confirmed through surgical pathology. Secondary objectives included assessing whether the risk of developing colorectal polyps was associated with factors such as advancing age, postmenopausal status, and comorbidities including hypertension, diabetes, obesity, and tobacco use. Retrospective cohort study Academic and tertiary referral center. Medical records were reviewed for patients diagnosed with endometrial polyps on hysteroscopic pathology, as well as patients confirmed to be free of polyps on post-hysterectomy pathology, who underwent colonoscopy between July 1, 2013, and July 30, 2023. Patients included in the study underwent both gynecologic surgery and colonoscopy at Cleveland Clinic Florida Hospitals during the study period. Patients with endometrial polyps identified on hysteroscopic pathology who underwent colonoscopy during the study period were designated as the case group. The control group comprised patients without endometrial polyps, as confirmed on post-hysterectomy pathology, who likewise underwent colonoscopy during the study period. Logistic regression analysis was performed to assess the association between the presence of endometrial and colorectal polyps. The final cohort included 306 patients. Of these, 240 were diagnosed with endometrial polyps, while 66 were found to have no polyps. The presence of colonic polyps was examined in both groups. Patients with endometrial polyps had a significantly higher prevalence of colorectal polyps than those without endometrial polyps (80.4% vs. 66.7%, p = 0.0179). No other demographic or clinical variables showed statistically significant differences between the groups. These findings suggest that the prevalence of colorectal polyps is significantly higher in patients with endometrial polyps compared to those without. This may support the consideration of earlier colorectal cancer screening in this population, regardless of age or traditional risk factors.