Distribution of FOXL2-positive stromal cells in the ovary.

Masayoshi Fujisawa (5844029), Aye Moh-Moh-Aung (5844032), Zheng Zeng (383660), Teizo Yoshimura (199118), Yoji Wani (5844035), Akihiro Matsukawa (197990)
2018 · doi:10.1371/journal.pone.0205494.g001 · W6904477413
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This study characterized the distribution of FOXL2-positive stromal cells in normal ovarian cortex and various primary and secondary ovarian carcinomas using immunostaining.

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This histopathological study examined the distribution of FOXL2-positive stromal cells within normal ovarian tissue and various types of ovarian malignancies. Researchers utilized immunostaining to demonstrate that nearly all stromal and granulosa cells in healthy ovaries express nuclear FOXL2, whereas vascular endothelial cells remain negative. The analysis further revealed that most spindle-shaped stromal cells in primary mucinous, serous, and metastatic carcinomas retain this positivity, although primary endometrioid carcinomas exhibited only sparse FOXL2 expression. This paper is centrally about ovarian cancer pathology and does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

(A and B) Normal ovarian cortex. Almost all stromal cells as well as granulosa cells (arrow head) show nuclear positivity for FOXL2. By contrast, none of the cells that constitute blood vessels (asterisk) have nuclear FOXL2. (C and D) Primary mucinous carcinoma. (E and F) Primary serous carcinoma. (G and H) Secondary ovarian tumor (ovarian metastasis of rectal adenocarcinoma). Most stromal spindle cells show nuclear positivity for FOXL2. (I and J) Primary endometrioid carcinoma, a rare example of primary ovarian cancer containing only a few FOXL2-postive cells. H&E (left panels) and FOLX2 immunostaining of the corresponding area (right panels; only nuclear staining is considered positive). Arrows indicate FOXL2-positive cells. The bar in (A) indicates 50μm, and the magnification is identical for all the pictures.
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Ovarian stromal cells as a source of cancer-associated fibroblasts in human epithelial ovarian cancer: A histopathological study Fig 1 Distribution of FOXL2-positive stromal cells in the ovary. (A and B) Normal ovarian cortex. Almost all stromal cells as well as granulosa cells (arrow head) show nuclear positivity for FOXL2. By contrast, none of the cells that constitute blood vessels (asterisk) have nuclear FOXL2. (C and D) Primary mucinous carcinoma. (E and F) Primary serous carcinoma. (G and H) Secondary ovarian tumor (ovarian metastasis of rectal adenocarcinoma). Most stromal spindle cells show nuclear positivity for FOXL2. (I and J) Primary endometrioid carcinoma, a rare example of primary ovarian cancer containing only a few FOXL2-postive cells. H&E (left panels) and FOLX2 immunostaining of the corresponding area (right panels; only nuclear staining is considered positive). Arrows indicate FOXL2-positive cells. The bar in (A) indicates 50μm, and the magnification is identical for all the pictures.

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