Polymorphism of transforming growth factor β1 T869C gene and endometriosis

Objective:To explore the relationship between tumor necrosis factor(TGF) β1T869C gene polymorphism,its serum level and endometriosis. Methods:PCR was used to amplify the fragments of TGF β1T869C gene,RELP was performed by Pst Ⅰ endonuclease,then the results were confirmed by gene sequencing. Results:The frequencies of TGF β1 T869 C/C,C/T,T/T phenotypes in endometriosis group were 0.210 0,0.600 0 and 0.190 0,respectively,while in control group,the frequencies were 0.250 0,0.580 0 and 0.170 0,respectively;the gene frequencies of TGFβ1 T869C and TGFβ1 T869T in endometriosis group were 0.510 0 and 0.490 0,respectively,while in control group,the frequencies were 0.540 0 and 0.460 0,respectively;there was no significant difference in the frequencies of various TGF β1T869C genotypes between endometriosis group and control group(P0.05). Conclusion:There is no correlation between TGF β1T869C gene polymorphism and endometriosis.