Effect of sex steroid hormones on the serum prolactin concentration

Takeshi Yoshida, Yoshida T, T. Yoshida, Hattori Y, Y Hattori, YUTAKA HATTORI, Suzuki H, H Suzuki, Hiroshi Suzuki, Kiichiro Noda, K. Noda, Noda K
The Tohoku Journal of Experimental Medicine · 1979 · doi:10.1620/tjem.127.119 · PMID:760259
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In women with uterine endometriosis or taking oral contraceptives, combined estrogen-gestagen regimens significantly increased serum prolactin levels during treatment, which normalized after discontinuation.

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This 1979 study investigated changes in serum prolactin concentrations among women taking oral contraceptive pills and patients receiving combined estrogen-gestagen regimens for uterine endometriosis. The researchers found that prolactin levels more than doubled within one week of starting medication, continued to rise over the next three weeks, and returned to normal values one week after discontinuation. These results indicate an inverse correlation between prolactin and gonadotropin secretions during steroid hormone administration, a phenomenon also observed in postpartum periods or patients with galactorrhea-amenorrhea. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

Changes in serum prolactin concentration were investigated in women taking an oral contraceptive pill and patients treated with combined estrogen-gestagen regimens for uterine endometriosis. The serum prolactin value increased more than twice the initial level one week after the beginning of medication and continued to increase over succeeding three weeks, and it returned to the normal value at one week after discontinuation of the medication. The results obtained demonstrate that an inverse correlation of prolactin and gonadotropin secretions occurred during administration of the steroid sex hormones as seen in post partum period or patients with galactorrhea-amenorrhea. Side effects which may be associated with such combined steroid hormone has also been discussed.
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Keywords

prolactin, oral contraceptive pill 1979 Volume 127 Issue 2 Pages 119-122 Details

Abstract

Changes in serum prolactin concentration were investigated in women taking an oral contraceptive pill and patients treated with combined estrogen-gestagen regimens for uterine endometriosis. The serum prolactin value increased more than twice the initial level one week after the beginning of medication and continued to increase over succeeding three weeks, and it returned to the normal value at one week after discontinuation of the medication. The results obtained demonstrate that an inverse correlation of prolactin and gonadotropin secretions occurred during administration of the steroid sex hormones as seen in post partum period or patients with galactorrhea-amenorrhea. Side effects which may be associated with such combined steroid hormone has also been discussed. © Tohoku University Medical Press Favorites & Alerts Recently viewed articles - About this Journal The Tohoku Journal of Experimental Medicine (TJEM) was founded in 1920 by professors of Tohoku Imperial University, Medical School. The TJEM has been published continuously, except for the year of 1946 just after the World War II. The TJEM is open to original articles in all branches of medical sciences. The TJEM also covers the fields of disaster-prevention science, including earthquake archeology. - Submitted manuscripts will be screened for plagiarism with Similarity Check (https://www.crossref.org/services/similarity-check/). Announcements from publisher - Subscriptions Inland subscriptions should be sent to Tohoku University Medical Press, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, JAPAN. Subscriptions from abroad should be addressed to MARUZEN CO., LTD., EXPORT DEPARTMENT, Postal address: P.O.Box 75, Shinagawa, Tokyo 140-8799, JAPAN. e-mail: [email protected]

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Condition tags

endometriosis

MeSH descriptors

Gonadal Steroid Hormones Prolactin Contraceptives, Oral, Combined Contraceptives, Oral, Combined Contraceptives, Oral, Hormonal Contraceptives, Oral, Hormonal Estrogens Estrogens Female Gonadal Steroid Hormones Humans Progestins Progestins Prolactin

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