Etiology, Epidemiology, Pathophysiology, Diagnosis, Differential Diagnosis, Treatment and Prognosis of Endometriosis

Srinivas G, Ramanjaneyulu D.V., Muralinath E., Guruprasad M., Sravani Pragna K., Manjari P., Sony Sharlet E., T. Nikhil, V. Yaswanth Sai, D. Kusuma Latha, R. Faith Rani, P. Megha Varna, Sahil Manoranjan, M. Malavika Reddy
2024 · doi:10.5281/zenodo.14166779 · W6967994905
article OA: green CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-10 ⓘ

Endometriosis is an estrogen-dependent disease where uterine lining implants outside the uterus, causing pelvic pain and infertility, with ectopic tissue most commonly found on ovaries but also in other locations.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-28 · read from full text ⓘ

This paper provides a comprehensive overview of endometriosis, defining it as a chronic estrogen-dependent condition characterized by the ectopic implantation of functional endometrial tissue outside the uterine cavity. The authors review the diverse etiologies, including retrograde menstruation and coelomic metaplasia, while detailing the pathophysiology, clinical manifestations such as pelvic pain and infertility, and various treatment modalities. It also addresses the diagnostic process, differential diagnoses, and the prognostic factors influencing patient outcomes and disease progression. This paper is centrally about endometriosis — specifically covering its etiology, epidemiology, pathophysiology, diagnosis, and treatment strategies.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a chronic estrogen-dependent chronic condition manifested by the ectopic implantation of functional tissue lining the uterus (endometrial glands and stroma) outside of the uterine cavity. Endometriosis, a word derived from the Greek endo ‘'inside'', metra ''uterus'' and osis ‘' disease,'' remains to certain extent vague, with the most common clinical symptoms being pelvic pain as well as infertility. Most frequently, endometrial tissue is seen in ovaries, leading to the formation of chocolate cysts. Still, it can also be seen in the Fallopian tubes, uterosacral ligaments, the gastrointestinal tract, and less often in the pleura, pericardium, or the central nervous system. This activity explains about the evaluation and treatment of endometriosis and reviews the role of the healthcare team regarding management of patients afflicted with endometriosis.
Full text 3,236 characters · extracted from oa-doi-fallback · click to expand
Etiology, Epidemiology, Pathophysiology, Diagnosis, Differential Diagnosis, Treatment and Prognosis of Endometriosis Description Endometriosis is a chronic estrogen-dependent chronic condition manifested by the ectopic implantation of functional tissue lining the uterus (endometrial glands and stroma) outside of the uterine cavity. Endometriosis, a word derived from the Greek endo ‘'inside'', metra ''uterus'' and osis ‘' disease,'' remains to certain extent vague, with the most common clinical symptoms being pelvic pain as well as infertility. Most frequently, endometrial tissue is seen in ovaries, leading to the formation of chocolate cysts. Still, it can also be seen in the Fallopian tubes, uterosacral ligaments, the gastrointestinal tract, and less often in the pleura, pericardium, or the central nervous system. This activity explains about the evaluation and treatment of endometriosis and reviews the role of the healthcare team regarding management of patients afflicted with endometriosis. Files Etiology, Epidemiology, Pathophysiology, Diagnosis, Differential Diagnosis -Formatted Paper.pdf Files (502.0 kB) | Name | Size | Download all | |---|---|---| | md5:589d8eab1c241691f086bcdf131d76c3 | 502.0 kB | Preview Download | Additional details References - 1. Jenkins, S., Olive, D. L., & Haney, A. F. (1986). Endometriosis: Pathogenetic implications of the anatomic distribution. Obstetrics & Gynecology, 67(3), 335-338. - 2. Macer, M. L., & Taylor, H. S. (2012). Endometriosis and infertility: A review of the pathogenesis and treatment of endometriosis-associated infertility. Obstetrics and Gynecology Clinics of North America, 39(4), 535-549. - 3. Koninckx, P. R., Barlow, D., & Kennedy, S. (1999). Implantation versus infiltration: The Sampson versus the endometriotic disease theory. Gynecological Obstetric Investigation, 47(Suppl 1), 3-9; discussion 9-10. - 4. Matsuura, K., Ohtake, H., Katabuchi, H., & Okamura, H. (1999). Coelomic metaplasia theory of endometriosis: Evidence from in vivo studies and an in vitro experimental model. Gynecological Obstetric Investigation, 47(Suppl 1), 18-20; discussion 20-22. - 5. Konrad, L., Dietze, R., Kudipudi, P. K., Horné, F., & Meinhold-Heerlein, I. (2019). Endometriosis in MRKH cases as a proof for the coelomic metaplasia hypothesis? Reproduction, 158(2), R41-R47. - 6. Jabr, F. I., & Mani, V. (2014). An unusual cause of abdominal pain in a male patient: Endometriosis. Avicenna Journal of Medicine, 4(4), 99-101. - 7. Vercellini, P., Viganò, P., Somigliana, E., & Fedele, L. (2014). Endometriosis: Pathogenesis and treatment. Nature Reviews Endocrinology, 10(5), 261-275. - 8. Jerman, L. F., & Hey-Cunningham, A. J. (2015). The role of the lymphatic system in endometriosis: A comprehensive review of the literature. Biology of Reproduction, 92(3), 64. - 9. Cousins, F. L., O, D. F., & Gargett, C. E. (2018). Endometrial stem/progenitor cells and their role in the pathogenesis of endometriosis. Best Practice & Research Clinical Obstetrics & Gynaecology, 50, 27-38. - 10. Asghari, S., Valizadeh, A., Aghebati-Maleki, L., Nouri, M., & Yousefi, M. (2018). Endometriosis: Perspective, lights, and shadows of etiology. Biomedicine & Pharmacotherapy, 106, 163-174.

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisinfertility

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2024) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-05-10T10:26:39.742856+00:00
License: CC0 · commercial use OK