Tumor-like Lesions, Pathology of the Broad Ligament and Other Uterine Ligaments

Isabel Alvarado‐Cabrero
In: Encyclopedia of Pathology · 2022 · pp. 1–3 · doi:10.1007/978-3-319-28845-1_5649-1 · W4312459607
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⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-07-05 ⓘ

Adrenocortical rests, appearing as microscopic yellow nodules in the broad ligament or mesosalpinx, are incidental benign findings that may hypertrophy or rarely give rise to adenomas.

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The paper describes tumor-like lesions and the pathology of adrenal rest tissue located in the broad ligament and mesosalpinx, defining adrenal rests as small microscopic nodules of adrenal cortical cells. Based on referenced histologic findings, these rests have been identified in about 23% of carefully sectioned broad ligaments and are usually incidental, with all three adrenal cortical layers recognizable; they may remain benign, hypertrophy after adrenal destruction, or rarely develop into functional or nonfunctional cortical adenomas, with no specific clinical treatment described. A key caveat is that the content is largely descriptive and draws on prior case reports/series rather than presenting new study methods or data. Relevance to endometriosis: the entry includes an “Endometriosis” section noting ectopically located endometrial tissue involving the broad ligament, though the paper’s main focus is adrenal rest pathology in uterine ligaments.

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Adrenal Rest Synonyms Definition Small discrete microscopic nodules of adrenal cortical cells Clinical Features - Incidence Adrenocortical rest have been identified in 23% of carefully sectioned broad ligaments and collections of Hilus cells are occasionally encountered (Falls 1955). - Site Broad ligament or mesosalpinx Clinical Presentation They are most commonly an incidental finding (Adashi et al. 1980). - Treatment None - Outcome Benign accessory tissue (Sasano et al. 1997. Macroscopy Grossly, they appear as small microscopic, yellow nodules, but they may be obscured by fat (Roth et al. 1996). Microscopy Histologically all three cortical layers are recognizable. These remnants may hypertrophy secondary to adrenal destruction or may, rarely, give rise to a functional or nonfunctional cortical adenoma (Wild et al. 1988). Molecular Features Not clinically relevant Endometriosis Definition The presence of ectopically located endometrial tissue involving the broad... References and Further Reading Adashi, E. Y., Rosenshein, N. B., Parmley, T. H., & Woodruff, J. D. (1980). Histogenesis of the broad ligament adrenal rest. International Journal of Gynaecology and Obstetrics, 18, 102–104. Falls, J. L. (1955). Accesory adrenal cortex in the broad ligament. Incidence and functional significance. Cancer, 8, 143–150. Goldberg, J. M., Falcone, T., & Diamond, M. P. (2019). Current controversies in tubal disease, endometriosis, and pelvic adhesion. Fertility and Sterility, 112, 417–425. Henderson, D. W., Shilkin, K. B., & Whitaker, D. (1998). Reactive mesothelial hyperplasia vs mesothelioma, including mesothelioma in situ: A brief review. American Journal of Clinical Pathology, 110(3), 397–404. Kobayashi, H., Kawahara, N., Ogawa, K., & Yoshimoto, C. A. (2020). Relationship between endometriosis and obstetric complications. Reproductive Sciences, 27, 771–778. Roth, L. M., Davis, M. M., & Sutton, G. P. (1996). Steroid cell tumor of the broad ligament arising in an accessory ovary. Archives of Pathology & Laboratory Medicine, 120, 405–409. Rowlands, I. J., Nagle, C. M., Spurdle, A. B., & Webb, P. M. (2011). Gynecological conditions and the risk of endometrial cancer. Gynecologic Oncology, 123, 537–541. Sasano, H., Sato, S., Yajima, A., Akama, J., & Nagura, H. (1997). Adrenal rest tumor of the broad ligament: Case report with immunohistochemical study of steroidogenic enzymes. Pathology International, 47, 493–496. Wild, R. A., Albert, R. D., Zaino, R. J., et al. (1988). Virilizing Para-ovarian tumors: A consequence of Nelson’s syndrome? Obstetrics and Gynecology, 71, 1053–1156. Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 2022 Springer Nature Switzerland AG About this entry Cite this entry Alvarado-Cabrero, I. (2022). Tumor-like Lesions, Pathology of the Broad Ligament and Other Uterine Ligaments. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5649-1 Download citation DOI: https://doi.org/10.1007/978-3-319-28845-1_5649-1 Received: Accepted: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-319-28845-1 Online ISBN: 978-3-319-28845-1 eBook Packages: Living Reference MedicineReference Module Medicine

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