Multi-scale modelling of E. coli metabolism

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Abstract

In response to environmental and genetic perturbations, micro-organisms may regulate their metabolism both metabolically – via metabolite-enzyme interactions – and hierarchically – via modulating enzyme capacities. In this report, we develop a combined metabolic and genetic regulatory model of E. coli that may be used to test this multi-scale response.

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europepmc
last seen: 2026-05-19T01:45:01.086888+00:00