Long-term consistency of aperiodic and periodic physiomarkers in subthalamic local field potentials in Parkinson’s disease

Long-term consistency of aperiodic and periodic physiomarkers in subthalamic local field potentials in Parkinson’s disease | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Long-term consistency of aperiodic and periodic physiomarkers in subthalamic local field potentials in Parkinson’s disease Mariëlle J. Stam, Bernadette C.M. Wijk, Arthur W.G. Buijink, Dan Piña-Fuentes, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5230742/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 10 Jul, 2025 Read the published version in npj Parkinson's Disease → Version 1 posted 10 You are reading this latest preprint version Abstract Beta oscillations (± 13-35 Hz) and aperiodic spectral features extracted from local field potential (LFP) recordings have been identified as promising physiomarkers for adaptive deep brain stimulation (aDBS) in Parkinson's disease. However, the long-term consistency of these signal features in patients years after DBS implantation is still unclear. Bilateral subthalamic nucleus LFPs were recorded from twelve patients with an average inter-recording interval of 137 days, during rest, a finger-to-nose task and speech, with stimulation switched off and on. Intra-class correlation coefficients indicated moderate between-visit consistency for the aperiodic offset and exponent but good to excellent consistency of beta peak power. Task execution and stimulation induced aperiodic and power changes that were statistically comparable across visits. Results remained inconclusive regarding which beta peaks exhibited the strongest power suppression post-stimulation. Our findings support the potential of beta peak power as a primary physiomarker for aDBS, with aperiodic components serving as supplementary markers. Health sciences/Neurology/Neurological disorders/Movement disorders/Parkinsons disease Biological sciences/Physiology/Neurophysiology local field potentials beta oscillations Parkinson’s disease aperiodic component physiomarkers Full Text Additional Declarations No competing interests reported. Supplementary Files LFPConsistencySupplementaryMaterials.docx Cite Share Download PDF Status: Published Journal Publication published 10 Jul, 2025 Read the published version in npj Parkinson's Disease → Version 1 posted Editorial decision: Revision requested 09 Dec, 2024 Reviews received at journal 04 Nov, 2024 Reviewers agreed at journal 19 Oct, 2024 Reviews received at journal 15 Oct, 2024 Reviewers agreed at journal 15 Oct, 2024 Reviewers agreed at journal 15 Oct, 2024 Reviewers invited by journal 15 Oct, 2024 Editor assigned by journal 15 Oct, 2024 Submission checks completed at journal 14 Oct, 2024 First submitted to journal 09 Oct, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5230742","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":387909414,"identity":"7d656f22-ca1f-4a8b-b12f-4ad3006a888d","order_by":0,"name":"Mariëlle J. 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