The Therapeutic Effects of Mifepristone on Endometriosis Compared with Danazol

Objectives:To investigate the therapeutic effects and side effects of mifepristone on endometriosis.Methods: 90 patients suffering from endometriosis were selected and divided non-randomly into A and B groups.Group A was administered tablets of mifepristone 25 mg q.d.whereas Group B was administered tablets of Danazol 200 mg,Bid or Tid,for 6 months and followed up for 6～30 months. Results:For Group A the remission rate of symptoms was 95.6%,remission rate of physical signs was 75.6%,the pregnancy rate was 69.2%,and the recurrence rate was 31.8%. The group B was 97.5%,80%,71.4%,42.6% respectively.The differences in therapeutic effects and recurrence rate between the about groups did not have any statistic significance.The weight gain rate and abnormal rate of ALT of Group A were 6.6% and 2.2% separately,Group B was 95.6% and 42.2% respectively.The differences in the groups had obvious statistic significance.Conclusions: Mifepristone was similar to Danazol in the therapeutic effects on endomatriosis,but mifepristone has fewer side effects and was widely applied in clinical treatment.