Sexual dysfunctions in patients with well-compensated chronic liver disease: role of etiology, Mediterranean diet and quality of life in an observational cross-sectional study

Lorenzo Romano, Mariano Fonticelli, Filomena Morisco, Kateryna Priadko, Alba Rocco, Gerardo Nardone, L. Ranieri, Luigi Napolitano, Felice Crocetto, Biagio Barone, Davide Arcaniolo, Lorenzo Spirito, Celeste Manfredi, Antonietta Gerarda Gravina, Carmine Sciorio, Antonio Tufano, Antonio Cioffi, Ferdinando Fusco, Marco Romano, Marco De Sio
In: Sexual Medicine · 2025 · vol. 13(2) , pp. qfaf025 · doi:10.1093/sexmed/qfaf025 · PMID:40276567 · W4409750103
article OA: gold CC0
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This study found that chronic liver disease, particularly MASLD, has a high prevalence of sexual dysfunction, which is not influenced by Mediterranean diet adherence but is associated with quality of life.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Background: Sexual dysfunctions (SD) are highly prevalent in Chronic Liver Diseases (CLD). Whether Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) carries a higher risk of SD is unknown as is the role of dietary patterns or quality of Life (QoL). Aim: to assess (1) prevalence of SD in CLD; (2) whether MASLD is a risk factor for SD; (3) the role of adherence to Mediterranean Diet (MD) or QoL. Methods: Observational, cross-sectional study, 207 CLD patients (84 females and 123 males), median age 57 years (IQR:46-63); 96 (46.4%) MASLD; and 111 (53.6%) nonMASLD. Outcomes: SD were assessed through Female Sexual Function Index (FSFI) and International Index of Erectile Function (IIEF) questionnaires. Adherence to MD was evaluated by the MD Score, QoL by SFHS-12 questionnaire evaluating physical [(ie, Physical Component Summary (PCS)] and mental [(ie, Mental Component Summary (MCS)] health. Multivariate analysis identified predictors of SD. Results: 0.004), was not an independent protective factor against SD. Clinical Implications: SD should not be underestimated in CLD patients, in particular those with MASLD. Strengths and Limitations: Comprehensive study evaluating SD in a large cohort of CLD patients of both sexes, comparing MASLD vs nonMASLD. Due to its cross-sectional design, no conclusions can be drawn about cause and effect. Conclusions: (1) CLD, in particular MASLD, have a high prevalence of SD which is not affected by MD adherence, whereas QoL seems to play a role; (2) CLD patients should be evaluated for SD, for early diagnosis and treatment.

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

References (59)

Source provenance

openalex
last seen: 2026-05-10T10:23:22.614198+00:00
License: CC0 · commercial use OK