Study on Monitoring Spinal Cord Blood Flow During Spinal Osteotomy Using a Laser Speckle Imaging System

Study on Monitoring Spinal Cord Blood Flow During Spinal Osteotomy Using a Laser Speckle Imaging System | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Study on Monitoring Spinal Cord Blood Flow During Spinal Osteotomy Using a Laser Speckle Imaging System Zheng Ren, Jing Wang, Le Guo, Xiaolong Ye, Chang Xu, Yuan Ma This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4490905/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Objective : This study aims to utilize Laser Speckle Imaging (LSI) technology to thoroughly monitor and analyze the changes in spinal cord hemodynamics in rabbits undergoing Posterior Thoracolumbar Spinal Osteotomy (PTSO) surgery. Methods : Initially, we prepared the model for posterior thoracolumbar spine osteotomy.Subsequently, rabbits underwent monitoring using a laser speckle imaging system to document the different stages of spinal shortening,encompassing pre-osteotomy, post-osteotomy, post-shortening, and dural removal. Results: After statistical analysis, the blood perfusion volume of posterior spinal artery before and after osteotomy was significantly different (t=7.413, p=0.001), 95%CI (147.8-280.22). The blood perfusion volume of posterior spinal artery was significantly different before and after osteotomy (t=4.111, p=0.001), 95%CI (55.39 ~ 164.74). There were significant differences in posterior spinal artery perfusion before osteotomy and after dural removal (t=10.472, p=0.001), 95%CI (226.6-336.39). The blood perfusion volume of posterior spinal artery after osteotomy was significantly different from that after osteotomy shortening (t=-6.949, p=0.001), 95%CI (-66.34-6.949). The blood perfusion volume of posterior spinal artery after bone amputation was significantly different from that after dural removal (t=8.167, p=0.001), 95%CI (58.10 ~ 96.85). There were significant differences in posterior spinal artery perfusion between the patients with bone truncation and the patients with dural removal (t=13.227, p=0.001), 95%CI (144.96-197.90). Conclusion: Spinal cord blood flow can be utilized as a monitoring indicator for early prediction of spinal cord injury, while maintaining stable spinal cord blood flow may be a crucial factor in reducing spinal cord damage. Biological sciences/Physiology Health sciences/Medical research Physical sciences/Optics and photonics Spinal osteotomy surgery Spinal cord hemodynamics Laser speckle imaging technology Spinal cord blood perfusion Animal model Full Text Additional Declarations No competing interests reported. Supplementary Files data.xls Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4490905","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":313003244,"identity":"b9af6e2f-fcd4-4f6c-a342-131d2af83af4","order_by":0,"name":"Zheng Ren","email":"","orcid":"","institution":"Xinjiang Medical University","correspondingAuthor":false,"prefix":"","firstName":"Zheng","middleName":"","lastName":"Ren","suffix":""},{"id":313003245,"identity":"3a8b1a55-6c91-4f0f-8f96-7b690e2eb9dc","order_by":1,"name":"Jing Wang","email":"","orcid":"","institution":"Xinjiang Medical 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perfusion, Animal model","lastPublishedDoi":"10.21203/rs.3.rs-4490905/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4490905/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eObjective\u003c/strong\u003e: This study aims to utilize Laser Speckle Imaging (LSI) technology to thoroughly monitor and analyze the changes in spinal cord hemodynamics in rabbits undergoing Posterior Thoracolumbar Spinal Osteotomy (PTSO) surgery.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: Initially, we prepared the model for posterior thoracolumbar spine osteotomy.Subsequently, rabbits underwent monitoring using a laser speckle imaging system to document the different stages of spinal shortening,encompassing pre-osteotomy, post-osteotomy, post-shortening, and dural removal.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eAfter statistical analysis, the blood perfusion volume of posterior spinal artery before and after osteotomy was significantly different (t=7.413, p=0.001), 95%CI (147.8-280.22). 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