Clinical, Functional, and Radiological Outcomes of Transforaminal Lumbar Interbody Fusion in Degenerative Lumbar Spine Pathologies: A Prospective Study From a Tertiary Care Centre

Clinical, Functional, and Radiological Outcomes of Transforaminal Lumbar Interbody Fusion in Degenerative Lumbar Spine Pathologies: A Prospective Study From a Tertiary Care Centre | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Clinical, Functional, and Radiological Outcomes of Transforaminal Lumbar Interbody Fusion in Degenerative Lumbar Spine Pathologies: A Prospective Study From a Tertiary Care Centre Harshith J, Prem Kumar Kothimbakkam, Raghul VR, Bharath V, Sanjay Nallagounder Krishnasamy, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8064872/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background: Degenerative lumbar spine disorders are a frequent cause of persistent pain and disability. Transforaminal lumbar interbody fusion (TLIF) has become a standard procedure to achieve neural decompression and spinal stability through a posterior route. Objective: To assess the clinical, functional, and radiological results of TLIF in degenerative lumbar pathologies at a tertiary care centre in South India. Materials and Methods: A prospective observational study was conducted on 20 patients who underwent TLIF between June 2022 and January 2024. Functional recovery was evaluated using the Oswestry Disability Index (ODI), Visual Analogue Scale (VAS), and Short Form-12 (SF-12). Radiological analysis included fusion grading, disc height, and sagittal alignment. Statistical analysis was performed using SPSS v29, with significance set at p < 0.05. Results: The mean age of patients was 45.7 years. There was significant improvement in ODI (61.2 → 14.1), VAS (6.6 → 1.6), and SF-12 (12.7 → 44.9) (p < 0.001). Fusion was complete or near complete in all cases, with a minor complication rate of 15%. Fusion Grade I–II achieved in 100% of patients Conclusion: TLIF provides excellent outcomes in terms of pain relief, function, and fusion, with minimal morbidity. It remains a dependable option for degenerative lumbar conditions in Indian tertiary care practice. TLIF degenerative spine ODI VAS functional outcomes Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8064872","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":545468301,"identity":"a4e7a0e9-c21f-48e0-af64-bd49a144a4c6","order_by":0,"name":"Harshith J","email":"","orcid":"","institution":"Chettinad Hospital and Research Institute","correspondingAuthor":false,"prefix":"","firstName":"Harshith","middleName":"","lastName":"J","suffix":""},{"id":545468302,"identity":"358dc85d-d5cc-474c-b9db-fc9673f64e97","order_by":1,"name":"Prem Kumar Kothimbakkam","email":"","orcid":"","institution":"Chettinad Hospital and Research 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Centre\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"TLIF, degenerative spine, ODI, VAS, functional outcomes","lastPublishedDoi":"10.21203/rs.3.rs-8064872/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8064872/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cb\u003eBackground:\u003c/b\u003e\u003c/p\u003e\u003cp\u003eDegenerative lumbar spine disorders are a frequent cause of persistent pain and disability. Transforaminal lumbar interbody fusion (TLIF) has become a standard procedure to achieve neural decompression and spinal stability through a posterior route.\u003c/p\u003e\u003cp\u003e\u003cb\u003eObjective:\u003c/b\u003e\u003c/p\u003e\u003cp\u003eTo assess the clinical, functional, and radiological results of TLIF in degenerative lumbar pathologies at a tertiary care centre in South India.\u003c/p\u003e\u003cp\u003e\u003cb\u003eMaterials and Methods:\u003c/b\u003e\u003c/p\u003e\u003cp\u003eA prospective observational study was conducted on 20 patients who underwent TLIF between June 2022 and January 2024. Functional recovery was evaluated using the Oswestry Disability Index (ODI), Visual Analogue Scale (VAS), and Short Form-12 (SF-12). Radiological analysis included fusion grading, disc height, and sagittal alignment. Statistical analysis was performed using SPSS v29, with significance set at p\u0026thinsp;\u0026lt;\u0026thinsp;0.05.\u003c/p\u003e\u003cp\u003e\u003cb\u003eResults:\u003c/b\u003e\u003c/p\u003e\u003cp\u003eThe mean age of patients was 45.7 years. There was significant improvement in ODI (61.2 \u0026rarr; 14.1), VAS (6.6 \u0026rarr; 1.6), and SF-12 (12.7 \u0026rarr; 44.9) (p\u0026thinsp;\u0026lt;\u0026thinsp;0.001). Fusion was complete or near complete in all cases, with a minor complication rate of 15%. Fusion Grade I\u0026ndash;II achieved in 100% of patients\u003c/p\u003e\u003cp\u003e\u003cb\u003eConclusion:\u003c/b\u003e\u003c/p\u003e\u003cp\u003eTLIF provides excellent outcomes in terms of pain relief, function, and fusion, with minimal morbidity. It remains a dependable option for degenerative lumbar conditions in Indian tertiary care practice.\u003c/p\u003e","manuscriptTitle":"Clinical, Functional, and Radiological Outcomes of Transforaminal Lumbar Interbody Fusion in Degenerative Lumbar Spine Pathologies: A Prospective Study From a Tertiary Care Centre","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-18 06:49:29","doi":"10.21203/rs.3.rs-8064872/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"ac3cfb71-7355-4f37-b141-189186e5c609","owner":[],"postedDate":"November 18th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-11-18T06:49:29+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-18 06:49:29","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8064872","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8064872","identity":"rs-8064872","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}