[Effect of danazol on the function of the estrogen and progesterone receptor systems of the human endometrium].

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Danazol treatment in women with endometriosis did not alter endometrial estrogen receptors but significantly increased nuclear progesterone receptors.

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Abstract

Quantity of estrogen- and progesterone-specific binding sites was measured in endometrial tissues of 10 females treated with danazol during 3 month in a dose of 400 mg per day after surgical treatment for endometriosis. It was demonstrated that the amount of estrogen receptors in endometrium of the patients was the same as in endometrial tissue of healthy females but the quantity of nuclear progesterone receptors was markedly increased.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometrium Pregnadienes Receptors, Estrogen Receptors, Progesterone Danazol Endometrium Endometrium Female Humans Postoperative Care Pregnadienes Receptors, Estrogen Receptors, Estrogen Receptors, Progesterone Receptors, Progesterone Time Factors

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Source provenance

europepmc
last seen: 2026-06-20T06:14:18.781669+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:09:25.758913+00:00
License: CC0 · commercial use OK