Clinical analysis of functional optical zone after transepithelial photorefractive keratectomy in patients with different degrees of myopic astigmatism

Clinical analysis of functional optical zone after transepithelial photorefractive keratectomy in patients with different degrees of myopic astigmatism | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Clinical analysis of functional optical zone after transepithelial photorefractive keratectomy in patients with different degrees of myopic astigmatism HaiBo Tan, yi Lan, YongPing Dai This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6763091/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background To evaluate the effects of preoperative myopic astigmatism and anterior corneal surface curvature on the functional optical ZONE (FOZ) after transepithelial photorefractive keratectomy(transPRK). Methods This retrospective study was conducted on 78patients(130 eyes) with myopia and myopic astigmatism who underwent transPRK and they were grouped according to myopic astigmatism: control group(cylinder 0D ), moderate astigmatism group (-0.50 to -2.0D),and high astigmatism group(>-2.00 to -6.00D). The FOZ was measured and compared among the three groups at 6 mo postoperatively. The correlations between attempted corrections and anterior corneal surface curvature, corneal aberrations, Q value and the FOZ were analyzed. Results At 6 mo postoperatively, the mean FOZ was 5.06 ± 0.24mm in the control group, 5.19 ± 0.25mm in the moderate astigmatism group, and 5.35 ± 0.20mm in the high astigmatism group, with a statistically significant difference between the three groups (P < 0.001). The FOZ was significantly larger in the high astigmatism group than in the other groups, with statistically significant differences (p < 0.05,p < 0.001, respectively). Pearson correlation analysis showed that the changes in attempted equivalent spherical degrees, total corneal higher-order aberrations (HOAs), coma and spherical aberration changes were significantly negatively correlated with the FOZ among the three groups (all p < 0.05). Postoperative FOZ positively correlated with changs in the steep curvature (K2), mean curvature (Km), corneal astigmatism and Q value (all p < 0.01). Multiple linear regression analysis also suggested that the preoperative K2 was significantly positively correlated with the FOZ following the removal of other risk factors (p < 0.001). Conclusions Under the same programmed optical zone, high astigmatism eyes can obtain a larger FOZ and less induced coma. High curvature eyes can obtain a larger FOZ following transPRK. functional optical zone transepithelial photorefractive keratectomy myopic astigmatism anterior corneal curvature corneal aberrations Full Text Additional Declarations No competing interests reported. Tables are available in the Supplementary Files section. Supplementary Files TAble1.docx TAble2.docx TAble3.docx TAble4.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6763091","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":482933604,"identity":"4093b67d-094b-4778-9e5c-bc89e59f1b7c","order_by":0,"name":"HaiBo 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astigmatism","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"functional optical zone, transepithelial photorefractive keratectomy, myopic astigmatism, anterior corneal curvature, corneal aberrations","lastPublishedDoi":"10.21203/rs.3.rs-6763091/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6763091/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e\u003cp\u003eTo evaluate the effects of preoperative myopic astigmatism and anterior corneal surface curvature on the functional optical ZONE (FOZ) after transepithelial photorefractive keratectomy(transPRK).\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e\u003cp\u003eThis retrospective study was conducted on 78patients(130 eyes) with myopia and myopic astigmatism who underwent transPRK and they were grouped according to myopic astigmatism: control group(cylinder 0D ), moderate astigmatism group (-0.50 to -2.0D),and high astigmatism group(\u0026gt;-2.00 to -6.00D). The FOZ was measured and compared among the three groups at 6 mo postoperatively. The correlations between attempted corrections and anterior corneal surface curvature, corneal aberrations, Q value and the FOZ were analyzed.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e\u003cp\u003eAt 6 mo postoperatively, the mean FOZ was 5.06\u0026thinsp;\u0026plusmn;\u0026thinsp;0.24mm in the control group, 5.19\u0026thinsp;\u0026plusmn;\u0026thinsp;0.25mm in the moderate astigmatism group, and 5.35\u0026thinsp;\u0026plusmn;\u0026thinsp;0.20mm in the high astigmatism group, with a statistically significant difference between the three groups (P\u0026thinsp;\u0026lt;\u0026thinsp;0.001). The FOZ was significantly larger in the high astigmatism group than in the other groups, with statistically significant differences (p\u0026thinsp;\u0026lt;\u0026thinsp;0.05,p\u0026thinsp;\u0026lt;\u0026thinsp;0.001, respectively). Pearson correlation analysis showed that the changes in attempted equivalent spherical degrees, total corneal higher-order aberrations (HOAs), coma and spherical aberration changes were significantly negatively correlated with the FOZ among the three groups (all p\u0026thinsp;\u0026lt;\u0026thinsp;0.05). Postoperative FOZ positively correlated with changs in the steep curvature (K2), mean curvature (Km), corneal astigmatism and Q value (all p\u0026thinsp;\u0026lt;\u0026thinsp;0.01). Multiple linear regression analysis also suggested that the preoperative K2 was significantly positively correlated with the FOZ following the removal of other risk factors (p\u0026thinsp;\u0026lt;\u0026thinsp;0.001).\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e\u003cp\u003eUnder the same programmed optical zone, high astigmatism eyes can obtain a larger FOZ and less induced coma. High curvature eyes can obtain a larger FOZ following transPRK.\u003c/p\u003e","manuscriptTitle":"Clinical analysis of functional optical zone after transepithelial photorefractive keratectomy in patients with different degrees of myopic astigmatism","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-07-11 17:01:59","doi":"10.21203/rs.3.rs-6763091/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"b5668338-7418-47d1-970e-e83e62da4fc4","owner":[],"postedDate":"July 11th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-08-12T05:08:13+00:00","versionOfRecord":[],"versionCreatedAt":"2025-07-11 17:01:59","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6763091","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6763091","identity":"rs-6763091","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}